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Conclusion

Some evidence shows that HIV-1 itself changes the predilection for stroke, whose causes are also related to the immunosup­pression, to the risk behaviors for HIV-1 infection, and to the metabolic effects of combined therapies, especially those with PIs.

In Western countries, the survival of patients infected with a neuro- and possibly vasculotrophic virus has increased consider­ably. Moreover, with the aging of this popu­lation, the frequency of cerebrovascular dis­eases in the context of immunodepression and chronic viral infection may only increase in the near future. HIV-1-infected patients presenting with a suspicion of stroke must undergo an exhaustive work-up, because therapeutic decisions in that par­ticular situation should be rapidly individu­alized. If HIV-1 can indeed participate in the pathogenetic role of cerebrovascular diseases, the good blood-brain barrier pen­etration of new antiretroviral therapies could be a suitable therapeutic approach for this process.

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Source: Barbaro Giuseppe, Boccara Franc (eds.). Cardiovascular Disease in AIDS. 2nd edition. — Springer,2009. — 169 p.. 2009
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