CONCLUSIONS
The uPA/uPAR/suPAR molecules are involved in several immune functions including migration, adhesion, angiogenesis, fibrinolysis and cell proliferation. These are also important functions involved in the regulation of a viral infection as demonstrated in recent years research on uPA/uPAR/suPAR in HIV infection.
The uPA involvement in HIV trapping, the dependence of this mechanism of cell adhesion, and the strong prognostic value of suPAR in HIV disease progression. Future research will determine whether this knowledge can be implemented in HIV drug development and in the use of suPAR for initiating antiretroviral therapy and for monitoring treatment efficacy.CONFLICT OF INTEREST
Jesper Eugen-Olsen is co-founder and shareholder in ViroGates A/S, the company that produces the suPARnostic assay. No other authors have any conflict of interest.
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