Contents

Contributors vi

Preface viii

1 Development of the epidemic 1

Michael W Adler

2 The virus and the tests 6

PP Mortimer, C Loveday

3 Immunology of AIDS 12

Peter Beverley, Matthew Helbert

4 Natural history and management of early HIV infection 17

Adrian Mindel, Melinda Tenant-Flowers

5 Tumours in HIV 23

Caroline H Bridgewater, Margaret F Spittle

6 AIDS and the lung 30

Rob Miller

7 Gastrointestinal and hepatic manifestations 38

Ian McGowan, Ian VD Weller

8 Neurological manifestations 42

Hadi Manji

9 Treatment of infections and antiviral therapy 46

Ian VD Weller, IG Williams

10 HIV infection and AIDS in the developing world 59

Alison D Grant, Kevin M De Cock

11 Injection drug use-related HIV infection 65

RP Brettle

12 HIV infection in children 73

Gareth Tudor-Williams, Diana Gibb

13 HIV counselling and the psychosocial management of patients with HIV or AIDS 82

Sarah Chippindale, Lesley French

14 Palliative care and pain control in HIV and AIDS 86

Rob George, Chris Far nham, Louise Schofield

15 Control of infection policies 95

IJ Hart, Celia Aitken

16 Strategies for prevention 99

John Imrie, Anne M Johnson

17 Being HIV antibody positive 106

Jonathan Grimshaw

18 Having AIDS 108

Caroline Guinness

Index 111