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Summary

The stealthy nature of MAP is rewarded by a chronic infection within the host, character­ized by long periods of asymptomatic disease. This ensures that the disease can spread quietly and efficiently within and between groups of animals.

Even animals that are able to mount robust responses to MAP infection are at risk of the pathogen circumventing normal control measures and eventually overtaking the host. Negative feedback mechanisms designed to con­trol immunopathological responses may, in fact, be contributing to a loss of protective immunity in the host. Although our understanding of host responses to MAP has progressed in recent years, the complicated biology associated with mycobacterial pathogens continues to thwart full comprehension.

References

Abdalla, A.E., Lambert, N., Duan, X. and Xie, J. (2016) Interleukin-10 family and tuberculosis: an old story renewed. International Journal of Biological Sciences 12(6), 710-717. DOI: 10.7150/ijbs.13881.

Adams, J.L. and Czuprynski, C. J. (1994) Mycobacterial cell wall components induce the production of TNF-α, IL-1, and IL-6 by bovine monocytes and the murine macrophage cell line RAW 264.7. Microbial Pathogenesis 16(6), 401-411. DOI: 10.1006∕mpat.1994.1040.

Akaki, T., Sato, K., Shimizu, T., Sano, C., Kajitani, H. et al. (1997) Effector molecules in expression of the antimicrobial activity of macrophages against Mycobacterium avium complex: roles of reactive nitro­gen intermediates, reactive oxygen intermediates, and free fatty acids. Journal of Leukocyte Biology 62(6), 795-804. DOI: 10.1002∕jlb.62.6.795.

Akhbar, J.M., Chan, J. and Casadevall, A. (2015) B cells and antibodies in the defense against Mycobacterium tuberculosis infection. Immunological Reviews 264, 167-181.

Albarrak, S.M., Waters, W.R., Stabel, J.R. and Hostetter, J.M. (2018) Evaluating the cytokine pro­file of the WC1+ γδ T cell subset in the ileum of cattle with the subclinical and clinical forms of MAP infection.

Veterinary Immunology and Immunopathology 201, 26-31. DOI: 10.1016/j. vetimm.2018.05.003.

Alonso-Hearn, M., Patel, D., Danelishvili, L., Meunier-Goddik, L. and Bermudez, L.E. (2008) The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell CDc42. Infection and Immunity 76(1), 170-178. DOI: 10.1128/IAI.01913-06.

Alonso-Hearn, M., Eckstein, T.M., Sommer, S. and Bermudez, L.E. (2010) A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence. Innate Immunity 16(4), 235-247. DOI: 10.1177/1753425909339811.

Alzuherri, H.M., Woodall, C.J. and Clarke, C.J. (1996) Increased intestinal TNF-α, IL-1β and IL-6 expres­sion in ovine paratuberculosis. Veterinary Immunology and Immunopathology 49(4), 331-345. DOI: 10.1016/0165-2427(95)05477-4.

Bannantine, J.P. and Bermudez, L.E. (2013) No holes barred: invasion of the intestinal mucosa by Mycobacterium avium subsp. paratuberculosis.

Bannantine, J.P., Huntley, J.F.J., Miltner, E., Stabel, J.R. and Bermudez, L.E. (2003) The Mycobacterium avium subsp. paratuberculosis 35 kDa protein plays a role in invasion of bovine epithelial cells. Microbiology 149(8), 2061-2069. DOI: 10.1099∕mic.0.26323-0.

Baquero, M.M. and Plattner, B.L. (2017) Bovine peripheral blood WC1 + and WC1 neg γδ T lympho­cytes modulate monocyte-derived macrophage effector functions during in vitro Mycobacterium avium subspecies paratuberculosis infection. Cellular Immunology 315, 34-44. DOI: 10.1016/j. cellimm.2017.01.009.

Belkaid, Y. and Tarbell, K. (2009) Regulatory T cells in the control of host-microorganism interactions. Annual Review of Immunology 27(1), 551-589. DOI: 10.1146∕annurev.immunol.021908.132723.

Boer, M.C., Joosten, S.A. and Ottenhoff, T.H.M. (2015) Regulatory T-cells at the interface between human host and pathogens in infectious diseases and vaccination. Frontiers in Immunology 6, 217.

DOI: 10.3389∕fimmu.2015.00217.

Buchbinder, E. I. and Desai, A. (2016) CTLA-4 and PD-1 pathways: similarities, differences, and implica­tions of their inhibition. American Journal of Clinical Oncology 39, 98-106.

Burrells, C., Clarke, C.J., Colston, A., Kay, J.M., Porter, J. et al. (1998) A study of immunological respons­es of sheep clinically-affected with paratuberculosis (Johne's disease). The relationship of blood, mesenteric lymph node and intestinal lymphocyte responses to gross and microscopic pathology. Veterinary Immunology and Immunopathology 66, 343-358.

Buza, J.J., Hikono, H., Mori, Y., Nagata, R., Hirayama, S. et al. (2004) Neutralization of interleukin-10 significantly enhances gamma interferon expression in peripheral blood by stimulation with johnin purified protein derivative and by infection with Mycobacterium avium subsp. paratuberculosis in experimentally infected cattle with paratuberculosis. Infection and Immunity 72(4), 2425-2428. DOI: 10.1128/IAI.72.4.2425-2428.2004.

Casey, M.E., Meade, K.G., Nalpas, N.C., Taraktsoglou, M., Browne, J.A. et al. (2015) Analysis of the bovine monocyte-derived macrophage response to Mycobacterium avium subspecies paratuber­culosis infection using RNA-seq. Frontiers in Immunology 6, 1-14. DOI: 10.3389∕fimmu.2015.00023.

Chabot, S., Wagner, J.S., Farrant, S. and Neutra, M.R. (2006) TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium. The Journal of Immunology 176(7), 4275-4283. DOI: 10.4049∕jimmunol.176.7.4275.

Chan, J., Mehta, S., Bharrhan, S., Chen, Y., Achkar, J.M. et al. (2014) The role of B cells and humoral immunity in Mycobacterium tuberculosis infection. Seminars in Immunology 26(6), 588-600. DOI: 10.1016∕j.smim.2014.10.005.

Charavaryamath, C., Gonzalez-Cano, P., Fries, P., Gomis, S., Doig, K. et al. (2013) Host respons­es to persistent Mycobacterium avium subspecies paratuberculosis infection in surgically iso­lated bovine ileal segments.

Clinical and Vaccine Immunology 20(2), 156-165. DOI: 10.1128/ CVI.00496-12.

Clarke, C.J. (1997) The pathology and pathogenesis of paratuberculosis in ruminants and other species. Journal of Comparative Pathology 116(3), 217-261. DOI: 10.1016∕S0021-9975(97)80001-1.

Coussens, P.M., Colvin, C.J., Rosa, G.J.M., Perez Laspiur, J. and Elftman, M.D. (2003) Evidence for a novel gene expression program in peripheral blood mononuclear cells from Mycobacterium avium subsp. paratuberculosis-infected cattle. Infection and Immunity 71(11), 6487-6498. DOI: 10.1128/ IAI.71.11.6487-6498.2003.

Coussens, P.M., Verman, N., Coussens, M.A., Elftman, M.D. and McNulty, A.M. (2004) Cytokine gene expression in peripheral blood mononuclear cells and tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis: evidence for an inherent proinflammatory gene expression pattern. Infection and Immunity 72(3), 1409-1422. DOI: 10.1128∕IAI.72.3.1409-1422.2004.

Coussens, P.M., Sipkovsky, S., Murphy, B., Roussey, J. and Colvin, C.J. (2012) Regulatory T cells in cat­tle and their potential role in bovine paratuberculosis. Comparative Immunology, Microbiology and Infectious Diseases 35(3), 233-239. DOI: 10.1016∕j.cimid.2012.01.004.

de Almeida, D.E., Colvin, C.J. and Coussens, PM. (2008) Antigen-specific regulatory T cells in bovine paratuberculosis. Veterinary Immunology and Immunopathology 125(3-4), 234-245. DOI: 10.1016∕j. vetimm.2008.05.019.

de Silva, K., Begg, D. and Whittington, R. (2011) The interleukin 10 response in ovine Johne's disease. Veterinary Immunology and Immunopathology 139(1), 10-16. DOI: 10.1016∕j.vetimm.2010.07.022.

de Silva, K., Begg, D.J., Plain, K.M., Purdie, A.C., Kawaji, S. et al. (2013) Can early host responses to my­cobacterial infection predict eventual disease outcomes? Preventive Veterinary Medicine 112(3-4), 203-212. DOI: 10.1016∕j.prevetmed.2013.08.006.

de Silva, K., Plain, K., J. Begg, D., C. Purdie, A.

and J. Whittington, R. (2015) CD4+ T-cells, γδ T-cells and B-cells are associated with lack of vaccine protection in Mycobacterium avium subspecies paratu­berculosis infection. Vaccine 33(1), 149-155. DOI: 10.1016∕j.vaccine.2014.10.082.

de Silva, K., Plain, K., Purdie, A., Begg, D. and Whittington, R. (2018) Defining resilience to mycobac­terial disease: characteristics of survivors of ovine paratuberculosis. Veterinary Immunology and Immunopathology 195, 56-64. DOI: 10.1016∕j.vetimm.2017.11.008.

Delvig, A.A., Lee, J.J., Chrzanowska-Lightowlers, Z.M. and Robinson, J.H. (2002) TGF-beta and IFN- gamma cross-regulate antigen presentation to CD4 T cells by macrophages. Journal of Leukocyte Biology 72, 163-166.

Divangahi, M., Khan, N. and Kaufmann, E. (2018) Beyond killing Mycobacterium tuberculosis: disease tolerance. Frontiers in Immunology 9, 2976. DOI: 10.3389∕fimmu.2018.02976.

Dorhoi, A. and Du Plessis, N. (2018) Monocytic myeloid-derived suppressor cells in chronic infections. Frontiers in Immunology 8, 1895. DOI: 10.3389∕fimmu.2017.01895.

du Plessis, N., Loebenberg, L., Kriel, M., von Groote-Bidlingmaier, F., Ribechini, E. et al. (2013) Increased frequency of myeloid-derived suppressor cells during active tuberculosis and after recent Mycobacterium tuberculosis infection suppresses T-cell function. American Journal of Respiratory and Critical Care Medicine 188(6), 724-732. DOI: 10.1164∕rccm.201302-0249OC.

Dudemaine, P.L., Fecteau, G., Lessard, M., Labrecque, O., Roy, J.P. et al. (2014) Increased blood­circulating interferon-γ, interleukin-17, and osteopontin levels in bovine paratuberculosis. Journal of Dairy Science 97(6), 3382-3393. DOI: 10.3168∕jds.2013-7059.

Everman, J.L., Danelishvili, L., Flores, L.G. and Bermudez, L.E. (2018) MAP1203 promotes Mycobacterium avium subspecies paratuberculosis binding and invasion to bovine epithelial cells. Frontiers in Cellular and Infection Microbiology 8, 217-226.

DOI: 10.3389∕fcimb.2018.00217.

Featherstone, C. (1997) M cells: portals to the mucosal immune system. The Lancet 350(9086), 1230. DOI: 10.1016∕S0140-6736(05)63467-8.

Flynn, J.L., Chan, J., Triebold, K.J., Dalton, D.K., Stewart, T.A. et al. (1993) An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. The Journal of Experimental Medicine 178(6), 2249-2254. DOI: 10.1084∕jem.178.6.2249.

Flynn, J.L., Chan, J. and Lin, P.L. (2011) Macrophages and control of granulomatous inflammation in tu­berculosis. Mucosal Immunology 4(3), 271-278. DOI: 10.1038∕mi.2011.14.

Frie, M.C., Sporer, K.R.B., Kirkpatrick, B.W. and Coussens, P.M. (2017) T and B cell activation profiles from cows with and without Johne's disease in response to in vitro stimulation with Mycobacterium avium subspecies paratuberculosis. Veterinary Immunology and Immunopathology 193-194, 50-56. DOI: 10.1016∕j.vetimm.2017.10.005.

Fulton, S.A., Cross, J.V., Toossi, Z.T. and Boom, W.H. (1998) Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-α, and interferon-γ in human monocytes infected with Mycobacterium tuberculosis H37Ra. The Journal of Infectious Diseases 178(4), 1105­1114. DOI: 10.1086/515698.

Gebert, A., Rothkotter, H.J. and Pabst, R. (1996) M cells in Peyer's patches of the intestine. International Reviews of Cytology 167, 91-159.

Guzman, E., Hope, J., Taylor, G., Smith, A.L., Cubillos-Zapata, C. et al. (2014) Bovine γδ T cells are a major regulatory T cell subset. The Journal of Immunology 193(1), 208-222. DOI: 10.4049/ jimmunol.1303398.

Harriff, M.J., Danelishvili, L., Wu, M., Wilder, C., McNamara, M. et al. (2009) Mycobacterium avium genes MAV_5138 and MAV_3679 are transcriptional regulators that play a role in invasion of epithelial cells, in part by their regulation of CipA, a putative surface protein interacting with host cell signaling path­ways. Journal of Bacteriology 191(4), 1132-1142. DOI: 10.1128∕JB.01359-07.

Hoek, A., Rutten, V.P., Kool, J., Arkesteijn, G.J., Bouwstra, R.J. et al. (2009) Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo. Veterinary Research 40, 6.

Hope, J.C., Thom, M.L., McCormick, P.A. and Howard, C.J. (2004) Interaction of antigen presenting cells with mycobacteria. Veterinary Immunology and Immunopathology 100(3-4), 187-195. DOI: 10.1016∕j.vetimm.2004.04.007.

Hostetter, J., Steadham, E., Haynes, J., Bailey, T. and Cheville, N. (2003) Phagosomal maturation and intracellular survival of Mycobacterium avium subspecies paratuberculosis in J774 cells. Comparative Immunology, Microbiology and Infectious Diseases 26(4), 269-283. DOI: 10.1016∕ S0147-9571(02)00070-X.

Hostetter, J., Kagan, R. and Steadham, E. (2005) Opsonization effects on Mycobacterium avium subsp. paratuberculosis—macrophage interactions. Clinical Diagnostics and Laboratory Investigation 12, 793-796.

Hussain, T., Shah, S.Z.A., Zhao, D., Sreevatsan, S. and Zhou, X. (2016) The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection. Cell Communication and Signaling 14(1), 29-42. DOI: 10.1186∕s12964-016-0152-z.

Ito, S., Ansari, P., Sakatsume, M., Dickensheets, H., Vazquez, N. et al. (1999) Interleukin-10 inhibits ex­pression of both interferon α- and interferon γ- induced genes by suppressing tyrosine phospho­rylation of STAT1. Blood 93(5), 1456-1463. DOI: 10.1182∕blood.V93.5.1456.

Jenvey, C.J., Shircliff, A.L., Bannantine, J.P. and Stabel, J.R. (2019) Phenotypes of macrophag­es present in the intestine are impacted by stage of disease in cattle naturally infected with Mycobacterium avium subsp. paratuberculosis. PLoS ONE 14(5), e0217649. DOI: 10.1371∕jour- nal.pone.0217649.

Joosten, S.A., van Meijgaarden, K.E., del Nonno, F., Baiocchini, A., Petrone, L. et al. (2016) Patients with tuberculosis have a dysfunctional circulating B-cell compartment, which normalizes following suc­cessful treatment. PLoS Pathogens 12(6), e1005687. DOI: 10.1371∕journal.ppat.1005687.

Kadivar, M., Petersson, J., Svensson, L. and Marsal, J. (2016) CD8αβ+ γδ T cells: A novel T cell subset with a potential role in inflammatory bowel disease. The Journal of Immunology 197(12), 4584-4592. DOI: 10.4049∕jimmunol.1601146.

Karcher, E.L., Beitz, D.C. and Stabel, J.R. (2008) Modulation of cytokine gene expression and secretion during the periparturient period in dairy cows naturally infected with Mycobacterium avium subsp. paratuberculosis. Veterinary Immunology and Immunopathology 123(3-4), 277-288. DOI: 10.1016∕j. vetimm.2008.02.006.

Kathaperumal, K., Park, S.-U., McDonough, S., Stehman, S., Akey, B. et al. (2008) Vaccination with re­combinant Mycobacterium avium subsp. paratuberculosis proteins induces differential immune responses and protects calves against infection by oral challenge. Vaccine 26(13), 1652-1663. DOI: 10.1016∕j.vaccine.2008.01.015.

Kaufmann, S.H. (1996) Gamma/delta and other unconventional T lymphocytes: what do they see and what do they do? Proceedings of the National Academy of Sciences 93(6), 2272-2279. DOI: 10.1073/ pnas.93.6.2272.

Khalifeh, M.S. and Stabel, J.R. (2004a) Effects of gamma interferon, interleukin-10, and transforming growth factor beta on the survival of Mycobacterium avium subsp. paratuberculosis in monocyte- derived macrophages from naturally infected cattle. Infection and Immunity 72(4), 1974-1982. DOI: 10.1128∕IAI.72.4.1974-1982.2004.

Khalifeh, M.S. and Stabel, J.R. (2004b) Upregulation of transforming growth factor-beta and interleu­kin-10 in cows with clinical Johne's disease. Veterinary Immunology and Immunopathology 99(1-2), 39-46. DOI: 10.1016∕j.vetimm.2004.01.009.

Koets, A., Rutten, V., Hoek, A., van Mil, F., Muller, K. et al. (2002) Progressive bovine paratuberculo­sis is associated with local loss of CD4+ T cells, increased frequency of gamma delta T cells, and related changes in T-cell function. Infection and Immunity 70(7), 3856-3864. DOI: 10.1128/ IAI.70.7.3856-3864.2002.

Koets, A.P., Eda, S. and Sreevatsan, S. (2015) The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter. Veterinary Research 46(1), 61. DOI: 10.1186∕s13567-015-0185-0.

Kohno, K., Kataoka, J., Ohtsuki, T., Suemoto, Y., Okamoto, I. et al. (1997) IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect inde­pendently of IL-12. Journal of Immunology 158, 1541-1550.

Koo, H.C., Park, Y.H., Hamilton, M.J., Barrington, G.M., Davies, C.J. et al. (2004) Analysis of the im­mune response to Mycobacterium avium subsp. paratuberculosis in experimentally infected calves. Infection and Immunity 72(12), 6870-6883. DOI: 10.1128∕IAI.72.12.6870-6883.2004.

Lamont, E.A., O'Grady, S.M., Davis, W.C., Eckstein, T. and Sreevatsan, S. (2012) Infection with Mycobacterium avium subsp. paratuberculosis results in rapid interleukin-1 β release and macrophage transepithelial migration. Infection and Immunity 80(9), 3225-3235. DOI: 10.1128∕IAI.06322-11.

Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Calderon Gomez, E. et al. (2008) TLR-activated B cells suppress T cell-mediated autoimmunity. The Journal of Immunology 180(7), 4763-4773. DOI: 10.4049∕jimmunol.180.7.4763.

Larsen, A.B., Merkal, R.S. and Cutlip, R.C. (1975) Age of cattle as related to resistance to infection with Mycobacterium paratuberculosis. American Journal of Veterinary Research 36, 255-257.

Lee, H., Stabel, J.R. and Kehrli, M.E. (2001) Cytokine gene expression in ileal tissues of cattle infected with Mycobacterium paratuberculosis. Veterinary Immunology and Immunopathology 82(1-2), 73­85. DOI: 10.1016∕S0165-2427(01)00340-3.

Leite, F.L., Eslabao, L.B., Pesch, B., Bannantine, J.P., Reinhardt, T.A. etal. (2015) ZAP-70, CTLA-4 and prox­imal T cell receptor signaling in cows infected with Mycobacterium avium subsp. paratuberculosis. Veterinary Immunology and Immunopathology 167(1-2), 15-21. DOI: 10.1016∕j.vetimm.2015.06.017.

Lugton, I.W. (1999) Mucosa-associated lymphoid tissues as sites for uptake, carriage and excretion of tubercle bacilli and other pathogenic mycobacteria. Immunology and Cell Biology 77(4), 364-372. DOI: 10.1046∕j.1440-1711.1999.00836.x.

Maglione, PJ., Xu, J. and Chan, J. (2007) B cells moderate inflammatory progression and enhance bac­terial containment upon pulmonary challenge with Mycobacterium tuberculosis. The Journal of Immunology 178(11), 7222-7234. DOI: 10.4049∕jimmunol.178.11.7222.

Magombedze, G., Eda, S. and Ganusov, V.V. (2014) Competition for antigen between Th1 and Th2 re­sponses determines the timing of the immune response switch during Mycobacterium avium sub­species paratuberculosis infection in ruminants. PLoS Computational Biology 10(1), e1003414. DOI: 10.1371∕journal.pcbi.1003414.

Magombedze, G., Eda, S. and Stabel, J. (2015) Predicting the role of IL-10 in the regulation of the adap­tive immune responses in Mycobacterium avium subsp. paratuberculosis infections using math­ematical models. PLoS ONE 10(11), e0141539. DOI: 10.1371∕journal.pone.0141539.

Miltner, E., Daroogheh, K., Mehta, P.K., Cirillo, S.L.G., Cirillo, J.D. et al. (2005) Identification of Mycobacterium avium genes that affect invasion of the intestinal epithelium. Infection and Immunity 73(7), 4214-4221. DOI: 10.1128∕IAI.73.7.4214-4221.2005.

Moir, S. and Fauci, A.S. (2009) B cells in HIV infection and disease. Nature Reviews Immunology 9(4), 235-245. DOI: 10.1038∕nri2524.

Mombaerts, P., Arnoldi, J., Russ, F., Tonegawa, S. and Kaufmann, S.H.E. (1993) Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature 365(6441), 53-56. DOI: 10.1038∕365053a0.

Momotani, E., Whipple, D.L., Thiermann, A.B. and Cheville, N.F. (1988) Role of M cells and macrophages in the entrance of Mycobacterium paratuberculosis into domes of ileal Peyer's patches in calves. Veterinary Pathology 25(2), 131-137. DOI: 10.1177/030098588802500205.

Nagata, R., Kawaji, S., Minakawa, Y., Wang, X., Yanaka, T. et al. (2010) A specific induction of in­terleukin-10 by the Map41 recombinant PPE antigen of Mycobacterium avium subsp. para­tuberculosis. Veterinary Immunology and Immunopathology 135(1-2), 71-78. DOI: 10.1016/j. vetimm.2009.11.002.

Navarro, J.A., Ramis, G., Seva, J., Pallares, F.J. and Sanchez, J. (1998) Changes in lymphocyte subsets in the intestine and mesenteric lymph nodes in caprine paratuberculosis. Journal of Comparative Pathology 118(2), 109-121. DOI: 10.1016∕S0021-9975(98)80003-0.

Nembrini, C., Abel, B., Kopf, M. and Marsland, B.J. (2006) Strong TCR signaling, TLR ligands, and cy­tokine redundancies ensure robust development of type 1 effector T cells. The Journal of Immunology 176(12), 7180-7188. DOI: 10.4049∕jimmunol.176.12.7180.

Nicol, L., Wilkie, H., Gossner, A., Watkins, C., Dalziel, R. et al. (2016) Variations in T cell transcription fac­tor gene structure and expression associated with the two disease forms of sheep paratuberculosis. Veterinary Research 47(1), 83. DOI: 10.1186∕s13567-016-0368-3.

O'Donnell, M.A., Luo, Y., Chen, X., Szilvasi, A., Hunter, S.E. et al. (1999) Role of IL-12 in the induction and potentiation of IFN-gamma in response to Bacillus Calmette-Guerin. Journal of Immunology 163, 4246-4252.

Okagawa, T., Konnai, S., Nishimori, A., Ikebuchi, R., Mizorogi, S. et al. (2016) Bovine immunoinhibitory receptors contribute to suppression of Mycobacterium avium subsp. paratuberculosis-specific T-cell responses. Infection and Immunity 84(1), 77-89. DOI: 10.1128/IAI.01014-15.

Onishi, R.M. and Gaffen, S.L. (2010) Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 129(3), 311-321. DOI: 10.1111∕j.1365-2567.2009.03240.x.

Othieno, C., Hirsch, C.S., Hamilton, B.D., Wilkinson, K., Ellner, J.J. et al. (1999) Interaction of Mycobacterium tuberculosis-induced transforming growth factor β1 and interleukin-10. Infection and Immunity 67(11), 5730-5735. DOI: 10.1128/IAI.67.11.5730-5735.1999.

Park, H.-E., Park, H.-T., Jung, Y.H. and Yoo, H.S. (2018) Gene expression profiles of immune-regulatory genes in whole blood of cattle with a subclinical infection of Mycobacterium avium subsp. paratu­berculosis. PLoS ONE 13(4), e0196502. DOI: 10.1371/journal.pone.0196502.

Peleman, R., Wu, J., Fargeas, C. and Delespesse, G. (1989) Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells. The Journal of Experimental Medicine 170(5), 1751-1756. DOI: 10.1084∕jem.170.5.1751.

Plattner, B.L., Huffman, E.L. and Hostetter, J.M. (2013) Gamma-delta T-cell responses during subcutane­ous Mycobacterium avium subspecies paratuberculosis challenge in sensitized or naive calves using matrix biopolymers. Veterinary Pathology 50(4), 630-637. DOI: 10.1177/0300985812463404.

Ponnusamy, D., Periasamy, S., Tripathi, B.N. and Pal, A. (2013) Mycobacterium avium subsp. paratuber­culosis invades through M cells and enterocytes across ileal and jejunal mucosa of lambs. Research in Veterinary Science 94(2), 306-312. DOI: 10.1016∕j.rvsc.2012.09.023.

Pott, J., Basler, T., Duerr, C.U., Rohde, M., Goethe, R. et al. (2009) Internalization-dependent recognition of Mycobacterium avium ssp. paratuberculosis by intestinal epithelial cells. Cellular Microbiology 11(12), 1802-1815. DOI: 10.1111∕j.1462-5822.2009.01372.x.

Purdie, A.C., Plain, K.M., Begg, D.J., de Silva, K. and Whittington, R.J. (2012) Expression of genes as­sociated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection. Comparative Immunology, Microbiology and Infectious Diseases 35(2), 151-162. DOI: 10.1016∕j.cimid.2011.12.007.

Rahim, S.S., Khan, N., Boddupalli, C.S., Hasnain, S.E. and Mukhopadhyay, S. (2005) Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor. Immunology 114(3), 313-321. DOI: 10.1111∕j.1365-2567.2005.02107.x.

Robinson, M.W., O'Brien, R., Mackintosh, C.G., Clark, R.G. and Griffin, J.F.T. (2011) Immunoregulatory cytokines are associated with protection from immunopathology following Mycobacterium avium subspecies paratuberculosis infection in red deer. Infection and Immunity 79(5), 2089-2097. DOI: 10.1128/IAI.00779-10.

Sajiki, Y., Konnai, S., Okagawa, T., Nishimori, A., Maekawa, N. et al. (2018) Prostaglandin E2 induction suppresses the Th1 immune responses in cattle with Johne's disease. Infection and Immunity 86(5), e00910-17. DOI: 10.1128/IAI.00910-17.

Santema, W., Rutten, V., Segers, R., Poot, J., Hensen, S. et al. (2013) Postexposure subunit vaccina­tion against chronic enteric mycobacterial infection in a natural host. Infection and Immunity 81(6), 1990-1995. DOI: 10.1128/IAI.01121-12.

Saunders, B.M., Frank, A.A., Cooper, A.M. and Orme, I.M. (1998) Role of γδ T cells in immunopathology of pulmonary Mycobacterium avium infection in mice. Infection and Immunity 66(11), 5508-5514. DOI: 10.1128/IAI.66.11.5508-5514.1998.

Secott, T.E., Lin, T.L. and Wu, C.C. (2001) Fibronectin attachment protein homologue mediates fibronectin binding by Mycobacterium avium subsp. paratuberculosis. Infection and Immunity 69(4), 2075-2082. DOI: 10.1128/IAI.69.4.2075-2082.2001.

Secott, T.E., Lin, T.L. and Wu, C.C. (2004) Mycobacterium avium subsp. paratuberculosis fibronectin at­tachment protein facilitates M-cell targeting and invasion through a fibronectin bridge with host integrins. Infection and Immunity 72(7), 3724-3732. DOI: 10.1128/IAI.72.7.3724-3732.2004.

Shankar, G., Pestano, L.A. and Bosch, M.L. (2003) Interferon-gamma added during bacillus Calmette- Guerin induced dendritic cell maturation stimulates potent Th1 immune responses. Journal of Translational Medicine 1(1), 7. DOI: 10.1186/1479-5876-1-7.

Shin, S.J., Chang, C.-F., Chang, C.-D., McDonough, S.P., Thompson, B. et al. (2005) In vitro cellular immune responses to recombinant antigens of Mycobacterium avium subsp. paratuberculosis. Infection and Immunity 73(8), 5074-5085. DOI: 10.1128/IAI.73.8.5074-5085.2005.

SigurSardottir, O.G., Press, C.M. and Evensen, 0. (2001) Uptake of Mycobacterium avium subsp. para­tuberculosis through the distal small intestinal mucosa in goats: an ultrastructural study. Veterinary Pathology 38(2), 184-189. DOI: 10.1354∕vp.38-2-184.

SigurSardottir, O., Valheim, M. and Press, C.M. (2004) Establishment of Mycobacterium avium subsp. paratuberculosis infection in the intestine of ruminants. Advanced Drug Delivery Reviews 56(6), 819­834. DOI: 10.1016∕j.addr.2003.10.032.

SigurSardottir, O.G., Bakke-McKellep, A.M., Djonne, B. and Evensen, O. (2005) Mycobacterium avium subsp. paratuberculosis enters the small intestinal mucosa of goat kids in areas with and with­out Peyer's patches as demonstrated with the everted sleeve method. Comparative Immunology, Microbiology and Infectious Diseases 28(3), 223-230. DOI: 10.1016∕j.cimid.2005.01.004.

Smeed, J.A., Watkins, C.A., Rhind, S.M. and Hopkins, J. (2007) Differential cytokine gene expression profiles in the three pathological forms of sheep is an important component of the anti-inflammatory response in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes. Microbial Pathogenesis 41, 59-66.

Smith, R.L., Schukken, Y.H. and Grohn, Y.T. (2015) A new compartmental model of Mycobacterium avium subsp. paratuberculosis infection dynamics in cattle. Preventive Veterinary Medicine 122(3), 298­305. DOI: 10.1016∕j.prevetmed.2015.10.008.

Souza, C.D., Evanson, O.A. and Weiss, D.J. (2006) Mitogen activated protein kinase p38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes. Microbial Pathogenesis 41(2-3), 59-66. DOI: 10.1016/j. micpath.2006.04.002.

Souza, C., Davis, W.C., Eckstein, T.M., Sreevatsan, S. and Weiss, D.J. (2013) Mannosylated lipoarabi- nomannans from Mycobacterium avium subsp. paratuberculosis alters the inflammatory response by bovine macrophages and suppresses killing of Mycobacterium avium subsp. avium organisms. PLoS ONE 8(9), 375924. DOI: 10.1371∕journal.pone.0075924.

Stabel, J.R. (2000) Transitions in immune responses to Mycobacterium paratuberculosis. Veterinary Microbiology 77(3-4), 465-473. DOI: 10.1016∕S0378-1135(00)00331-X.

Stabel, J.R. and Ackermann, M.R. (2002) Temporal Mycobacterium paratuberculosis infection in T-cell receptor (TCR)-alpha and TCR-delta-deficient mice. Veterinary Immunology and Immunopathology 89(3-4), 127-132. DOI: 10.1016∕S0165-2427(02)00167-8.

Stabel, J.R. and Khalifeh, M.S. (2008) Differential expression of CD5 on B lymphocytes in cattle infected with Mycobacterium avium subsp. paratuberculosis. Veterinary Immunology and Immunopathology 126(3-4), 211-219. DOI: 10.1016∕j.vetimm.2008.07.004.

Stabel, J.R., Kimura, K. and Robbe-Austerman, S. (2007) Augmentation of secreted and intracellular gamma interferon following johnin purified protein derivative sensitization of cows naturally infected with Mycobacterium avium subsp. paratuberculosis. Journal of Veterinary Diagnostic Investigation 19(1), 43-51. DOI: 10.1177/104063870701900107.

Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L. et al. (1994) Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263(5147), 678-681. DOI: 10.1126∕science.8303277.

Sugawara, I., Yamada, H., Kaneko, H., Mizuno, S., Takeda, K. et al. (1999) Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infection and Immunity 67(5), 2585-2589. DOI: 10.1128/IAI.67.5.2585-2589.1999.

Sweeney, R.W., Jones, D.E., Habecker, P. and Scott, P. (1998) Interferon-gamma and interleukin 4 gene expression in cows infected with Mycobacterium paratuberculosis. American Journal of Veterinary Research 59(7), 842-847.

Tanaka, S., Itohara, S., Sato, M., Taniguchi, T. and Yokomizo, Y. (2000) Reduced formation of BALB/c mice inoculated with Mycobacterium avium subsp. paratuberculosis. Veterinary Pathology 37, 415-421.

Tanaka, S., Sato, M., Onitsuka, T., Kamata, H. and Yokomizo, Y. (2005) Inflammatory cytokine gene ex­pression in different types of granulomatous lesions during asymptomatic stages of bovine paratu­berculosis. Veterinary Pathology 42(5), 579-588. DOI: 10.1354∕vp.42-5-579.

Taylor, D.L., Zhong, L., Begg, D.J., de Silva, K. and Whittington, R.J. (2008) Toll-like receptor genes are differentially expressed at the sites of infection during the progression of Johne's disease in outbred sheep. Veterinary Immunology and Immunopathology 124(1-2), 132-151. DOI: 10.1016/j. vetimm.2008.02.021.

Teixeira, L.K., Fonseca, B.P.F., Vieira-de-Abreu, A., Barboza, B.A., Robbs, B.K. et al. (2005) IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation. The Journal of Immunology 175(9), 5931-5939. DOI: 10.4049/jimmunol.175.9.5931.

Thirunavukkarasu, S., de Silva, K., Whittington, R.J. and Plain, K.M. (2013) In vivo and in vitro expres­sion pattern of Toll-like receptors in Mycobacterium avium subspecies paratuberculosis infection. Veterinary Immunology and Immunopathology 156(1-2), 20-31. DOI: 10.1016/j.vetimm.2013.08.008. Triccas, J.A., Sun, L., Palendira, U. and Britton, W.J. (2002) Comparative affects of plasmid-encoded in­terleukin 12 and interleukin 18 on the protective efficacy of DNA vaccination against Mycobacterium tuberculosis. Immunology and Cell Biology 80(4), 346-350. DOI: 10.1046/j.1440-1711.2002.01087.x. Tuo, W., Estes, D.M. and Brown, W.C. (1999) Comparative effects of interleukin-12 and interleukin-4 on cytokine responses by antigen-stimulated memory CD4+ T cells of cattle: IL-12 enhances IFN- gamma production, whereas IL-4 has marginal effects on cytokine expression. Journal of Interferon & Cytokine Research 19(7), 741-749. DOI: 10.1089/107999099313587.

Tyrer, P., Foxwell, A.R., Cripps, A.W., Apicella, M.A. and Kyd, J.M. (2006) Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium. Infection and Immunity 74(1), 625­631. DOI: 10.1128/IAI.74.1.625-631.2006.

Uzonna, J.E., Chilton, P., Whitlock, R.H., Habecker, P.L., Scott, P. et al. (2003) Efficacy of commercial and field-strain Mycobacterium paratuberculosis vaccinations with recombinant IL-12 in a bovine experimental infection model. Vaccine 21(23), 3101-3109. DOI: 10.1016/S0264-410X(03)00261-5.

Valheim, M., Sigurdardottir, O.G., Storset, A.K., Aune, L.G. and Press, C.M. (2004) Characterization of macrophages and occurrence of T cells in intestinal lesions of subclinical paratuberculosis in goats. Journal of Comparative Pathology 131(2-3), 221-232. DOI: 10.1016/j.jcpa.2004.04.004.

Wang, J., Wakeham, J., Harkness, R. and Xing, Z. (1999) Macrophages are a significant source of type 1 cytokines during mycobacterial infection. Journal of Clinical Investigation 103(7), 1023-1029. DOI: 10.1172/JCI6224.

Waters, W.R., Stabel, J.R., Sacco, R.E., Harp, J.A., Pesch, B.A. et al. (1999) Antigen-specific B-cell unre­sponsiveness induced by chronic Mycobacterium avium subsp. paratuberculosis infection of cattle. Infection and Immunity 67(4), 1593-1598.

Waters, W.R., Miller, J.M., Palmer, M.V., Stabel, J.R., Jones, D.E. et al. (2003) Early induction of humoral and cellular immune responses during experimental Mycobacterium avium subsp. paratuberculosis infection of calves. Infection and Immunity 71(9), 5130-5138. DOI: 10.1128/IAI.71.9.5130-5138.2003. Weiss, D.J., Evanson, O.A., Moritz, A., Deng, M.Q. and Abrahamsen, M.S. (2002) Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Infection and Immunity 70(10), 5556-5561. DOI: 10.1128/IAI.70.10.5556-5561.2002.

Weiss, D.J., Evanson, O.A., Deng, M. and Abrahamsen, M.S. (2004) Sequential patterns of gene expres­sion by bovine monocyte-derived macrophages associated with ingestion of mycobacterial organ­isms. Microbial Pathogenesis 37(4), 215-224. DOI: 10.1016/j.micpath.2004.07.001.

Weiss, D.J., Evanson, O.A., de Souza, C. and Abrahamsen, M.S. (2005) A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp. paratuberculosis. American Journal of Veterinary Research 66(4), 721-726. DOI: 10.2460∕ajvr.2005.66.721.

Weiss, D.J., Souza, C.D., Evanson, O.A., Sanders, M. and Rutherford, M. (2008) Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuber­culosis and Mycobacterium avium subsp. avium. Journal of Leukocyte Biology 83(1), 48-55. DOI: 10.1189∕jlb.0707490.

Whittington, R.J., Begg, D.J., de Silva, K., Plain, K.M. and Purdie, A.C. (2012) Comparative immunologi­cal and microbiological aspects of paratuberculosis as a model mycobacterial infection. Veterinary Immunology and Immunopathology 148(1-2), 29-47. DOI: 10.1016∕j.vetimm.2011.03.003.

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Source: Behr Marcel A., Stevenson K., Kapur V. (eds.). Paratuberculosis: Organism, Disease, Control. 2nd edition. — CAB International,2020. — 439 p.. 2020
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