CONCLUDING REMARKS

As evidenced by the reduced thymic cellularity, increase in apoptosis, and altered T cell develop­ment, HIV infection strongly affects thymic function. The viability of many thymocyte subsets is impaired either as a direct consequence of HIV infection or through indirect mechanisms.

acknowledgments

The work from our laboratory supporting this review was funded by the CIHR, the NIH, CANVAC, and Genome Canada. MLD is a recipient of a doctoral research award from the CIHR. RPS holds the Canada Research Chair in Human Immunology and is a senior scientist of the CIHR.

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