CONTENTS

Protease (PR) in Virus Life Cycle and AIDS Pathogenesis......................................................... 155

Effect of Protease Expression in Transgenic Models...................................................................

HIV PR and Cell Death................................................................................................................. 156

Evidence of Cell Death Caused by HIV PR........................................................................... 156

Necrosis.................................................................................................................................. 156

Mechanism of the Cell Death Caused by HIV PR................................................................. 157

Bcl-2....................................................................................................................................... 157

Procaspase-8........................................................................................................................... 157

Initiation Factor of Translation eIF4GI and Other Cellular Proteins........................................... 159

Model for Apoptosis vs. Necrosis................................................................................................. 159

Clinical Significance of the Cell Death Induced by PR............................................................... 159

Discordance............................................................................................................................ 159

Protease Inhibitor Resistance........................................................................................................ 160

Associations between Protease Mutations and Clinical or CD4 Outcome.................................. 162

In Vitro Effects of PR Mutations on Cell Killing......................................................................... 164

Conclusions................................................................................................................................... 164

References..................................................................................................................................... 165