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Many cardiac complications in acquired immunodeficiency syndrome (AIDS) that may be faced by emergency department (ED) physicians are due to opportunistic infections or malignancy, but they may also be associated with other aspects of human immunodeficiency virus (HIV) disease and its treatment (Table 1) [1].

The clinical expression of cardiac involvement is vari­able and is affected by the stage of HIV dis-

Table 1 cont.

HIV-associated cardiac disease Cardiac emergencies
C.
Fungal/yeast (Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans)
Nonbacterial thrombotic endocarditis Systemic embolization (lung, brain, kidney, spleen) disseminated intravascular coagulopathy
Pericardial

Pericardial effusion/pericarditis

A. Infectious

1. Bacterial (Mycobacterium tuberculosis,

M. avium intracellulare, Nocardia asteroides)

2. Viral (Coxsackievirus, Epstein-Barr virus, cytomegalovirus, adenovirus, herpes virus)

3. Fungal (Histoplasma capsulatum, Cryptococcus neoformans)

Cardiac tamponade, arrhythmias, CHF (for chronic pericardial effusions)
B. Idiopathic (HIV, autoimmune)
C. Uremic
D. Neoplastic (Kaposi’s sarcoma, non-Hodgkin’s lymphoma)

ease, the degree of immunodeficiency, and the drugs used to treat HIV disease-i.e., zidovudine and protease inhibitors (PIs) in the era of highly active antiretroviral thera­py (HAART) regimens-or to treat or prevent opportunistic infections and neoplasms (e.g., pentamidine, cotrimoxazole, interfer­on α) [2].

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Source: Barbaro Giuseppe, Boccara Franc (eds.). Cardiovascular Disease in AIDS. 2nd edition. — Springer,2009. — 169 p.. 2009
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