SUMMARY
Apoptosis is essential at virtually every stage of lymphocyte development and function. Successful resolution of a viral infection and maintenance of peripheral lymphocyte homeostasis requires the ability of cytotoxic lymphocytes to induce apoptosis in infected targets.
Peripheral lymphocytes become the apoptotic targets after they have outlived their usefulness. Failure to execute the apoptotic program can result in wide-ranging and tragic consequences, from ineffective clearance of infected cells to the development of autoimmune disorders resulting from otherwise innocuous infections.REFERENCES
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