The effect of HAART

With the improved control of HIV replication brought about by combination antiretroviral therapy, the frequency of AIDS- related malignancy is falling. The incidence of KS has dropped by approximately 75%. Sadly there has been a smaller decline in the incidence of NHL, although primary CNS lymphoma has also markedly declined. The lack of change in the incidence of systemic lymphoma reflects a heterogeneous and complex pathophysiology, not as susceptible to the influence of HAART as KS.

The effect on HPV-associated anogenital squamous cell carcinoma has also been disappointing.

This varied response highlights the continued need for innovative treatments, both in terms of chemotherapy and the manipulation of the immune response.