Dehydration
Mice require relatively large volumes of drinking water and easily become dehydrated. Hydration can be evaluated at necropsy by skin plasticity, “stickiness” of tissues, pale and contracted spleens, vascular hypovolemia, or elevated hematocrit.
Thorough anamnesis will often reveal failure of watering devices. Even if water bottles are full, sipper tubes can become obstructed, or if new, they can contain metal filings that interfere with water flow. Dehydration can also occur when water bottle sipper tubes are too high for young mice to reach or if newly arrived mice are unaccustomed to automatic watering devices. Dehydration frequently accompanies other diseases that preclude drinking, such as hydrocephalus. A consistent microscopic finding in dehydrated mice is massive thymic apoptosis (stress reaction).
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