Necrosis

Rats are susceptible to renal proximal tubular and papil­lary necrosis in response to administration of salicylates

FIG. 2.75. Adynamic ileus in a juvenile rat following intraperitoneal administration of chloral hydrate as an anesthetic agent. There is marked dilation of the small intestine.

and acetaminophen. Susceptibility is age-related, with older rats being most susceptible.