CONTENTS
Introduction................................................................................................................................... 319
Inappropriate T Cell Apoptosis: Direct HIV-Induced Cytopathicity and CD4 Cross-Linking....320 T Cell Exhaustion Induced by Continuous High T Cell Turnover.............................................
321Interference with Thymic Function.............................................................................................. 322
Appropriate T Cell Death: Chronic Immune Activation in HIV Pathogenesis.............................. 324
In Vivo Labeling Studies........................................................................................................ 325
HIV-Infected Individuals with Discordant Responses to Antiviral Therapy........................ 325
HIV-2...................................................................................................................................... 326
SIV.......................................................................................................................................... 326
Is Chronic Immune Activation Alone Enough to Induce CD4+ T Cell Loss?............................. 327
Why Are Only CD4+ and Not CD8+ T Cells Lost in HIV Infection?......................................... 327
Conclusion: An Integrated View.................................................................................................. 328
Acknowledgment.......................................................................................................................... 329
References..................................................................................................................................... 329