CONTENTS

Neurological Dysfunction Associated with HIV-1 Infection....................................................... 381

HIV-1 Gene Expression in the Nervous System...........................................................................

Neuronal Cell Death in HIV-1 Infection....................................................................................... 383

Direct Effect of Viral Proteins...................................................................................................... 384

Soluble Factors from Macrophages/Microglia Exposed to HIV-1.............................................. 386

Distinct HIV-1 Strains and Neurological Disease........................................................................ 388

Mechanisms of Neuronal Apoptosis............................................................................................. 388

Extrinsic Pathway.................................................................................................................. 388

Intrinsic Pathway.................................................................................................................... 389

Future Perspectives: Implications for Therapy............................................................................ 391

References..................................................................................................................................... 392