CONTENTS

Introduction: Overview of Complications Associated with HIV Therapy................................... 405

Complications of Therapy with Nucleoside Analogue Reverse Transcriptase Inhibitors...........

Mechanisms of Action: Therapeutic and Toxic Effects of NRTI Therapy........................... 406

Zidovudine Myopathy: A Tale of Two Treatment Eras........................................................ 410

Lipoatrophy: Pathological Fat Loss as a Mitochondrial Toxicity........................................ 410

Neuropathy: Contributions of Both HIV Disease and NRTI Therapy................................... 411

“Lymphocyte Mitochondrial Toxicity” and Didanosine Therapy: An Intersection of Therapeutic and Toxic Effects............................................................................................................................................ 412

Lactic Acidosis and Hyperlactatemia.................................................................................... 413

Complications Associated with the Use of HIV Protease Inhibitors......................................... 414

Diarrhea Associated with Nelfinavir: A Common Pathway

with Antiapoptotic Properties?.............................................................................................. 414

Ritonavir, Proteasomal Inhibition and Metabolic Complications........................................ 415

Conclusions................................................................................................................................... 415

References..................................................................................................................................... 415