Table of Contents
Section 1 Basic Concepts
Chapter 1 Lentiviral Biology and Cell Death................................................................................. 3
Eric M. Poeschla
Chapter 2 Regulation of Apoptosis...............................................................................................
21Maria Eugenia Guicciardi and Gregory J. Gores
Chapter 3 Approaches Used to Detect Apoptosis......................................................................... 35
Scott H. Kaufmann and Xue Wei Meng
Chapter 4 Consequences of HIV Infection on Thymus Function and T Cell Development......... 55
Daniel B. Graham and David J. McKean
Chapter 5 Deadly Intentions: Apoptosis in the Peripheral Immune System................................ 77
Michael J. Pinkoski
Section 2
Mechanisms of HIV-Associated Cell Death
Viral Factors
Chapter 6 Cell Death in HIV Infection: gp120.............................................................................. 95
Stacey R. Vlahakis
Chapter 7 Vpr............................................................................................................................... 109
Julian J. Lum and Andrew D. Badley
Chapter 8 Interference of the Nef Protein of HIV-1 with Pro- and Antiapoptotic
Pathways of T Cells...................................................................................................................... 127
Andreas Baur
Chapter 9 HIV-1 Tat and Apoptotic Death.................................................................................. 143
Sylviane Muller and Claude Desgranges
Chapter 10 HIV Protease (PR) and Cell Death........................................................................... 155
Zilin Nie, David R. McNamara, and Andrew D. Badley
Immune Mechanisms
Chapter 11 Immune Activation...................................................................................................
171Barbara N. Phenix and Savita Pahwa
Chapter 12 Impairment of HIV-Specific Immune Effector Cell Function................................. 185
Demetre C. Dakalakis and Eric S. Rosenberg
Infected vs. Uninfected Death
Chapter 13 Mechanisms of HIV-Infected vs. Uninfected T Cell Killing................................... 207
Jason F. Kreisberg, Gilad Doitsh, and Warner C. Greene
Chapter 14 Elevated Apoptosis of CD8+ T Lymphocytes during HIV-1 Infection..................... 229
John Zaunders, Jerome Estaquier, and Jacques Corbeil
Chapter 15 Autologous Cell-Mediated Killing........................................................................... 253
Georges Herbein
Chapter 16 Molecular Mechanisms of HIV-1 Syncytial Apoptosis........................................... 271
Christophe Lemaire, Jean-Luc Perfettini, Guido Kroemer,
and Catherine Brenner
Chapter 17 Nonapoptotic HIV-Induced T Cell Death................................................................. 279
Keiko Sakai, Matthew Smith-Raska, and Michael J. Lenardo
Chapter 18 Apoptosis in Organ Culture and Animal Models of HIV Disease........................... 293
Shailesh K. Choudhary and David Camerini
Section 3
Clinical Consequences of HIV-Induced Cell Death
Chapter 19 T Cell Dynamics and the Role of Apoptosis in HIV Infection................................ 319
Nienke Vrisekoop, Mette D. Hazenberg, Frank Miedema, and Jose A.M. Borghans
Chapter 20 Alteration of the Apoptotic Pathways in the Thymus during HIV Infection........... 335
Luchino Y. Cohen, Marie-Lise Dion, and Rafick-Pierre Sekaly
Chapter 21 Correlations between Apoptosis and HIV Disease Progression.............................. 355
David H. Dockrell and Anne J. Tunbridge
Chapter 22 HIV-1 Infection and Cell Death in the Nervous System.......................................... 381
Gareth Jones and Christopher Power
Chapter 23 Involvement of Apoptosis in Complications of HIV and Its Treatment..................
405David Nolan
Chapter 24 Apoptosis as a Pathogenic Mechanism of HIV-Associated
Opportunistic Infections............................................................................................................... 421
Sara Warren, Xian-Ming Chen, Nicholas F. LaRusso, and Andrew D. Badley
Section 4
Therapeutic Issues
Chapter 25 Direct Effects of Anti-HIV Therapeutics on Apoptosis........................................... 441
David Schnepple and Andrew D. Badley
Chapter 26 HIV-1 Reservoirs and Residual Viral Replication during Highly Active Antiretroviral Therapy................................................................................................................................................ 457
Roger J. Pomerantz and Giuseppe Nunnari
Chapter 27 Therapeutic Approaches to Modulation of Cell Death (non-HIV).......................... 475
Dara Ditsworth, Rebecca L. Elstrom, and Craig B. Thompson
Chapter 28 Immunotherapy of HIV Disease............................................................................... 505
Franco Lori, Laurene M. Kelly, Andrea Cossarizza, and Julianna Lisziewicz