Pyrazinamide

TREATMENT

Pyrazinamide (15-30 mg/kg PO q24h [maximum, 2 g] or 50-75 mg/kg PO twice a week [maximum, 4 g/dose]) kills mycobacteria by an unknown disruption of membrane transport. It is well absorbed orally and widely distributed throughout the body, including the CSF. Pyrazinamide is typically used for the first 2 months of therapy during treatment of active TB.

SPECIAL CONSIDERATIONS

Adverse events include hyperuricemia and hepatitis.