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Concluding Thoughts

With the cost of WGS falling, more researchers are conducting in-depth genome comparison and epidemiological studies using this tech­nology. WGS analysis of isolates with defined phenotype, virulence or pathogenicity and functional/virulence studies of genomically divergent strains should provide further in­sights into these distinct traits and genomic polymorphisms.

More targeted studies are re­quired to determine the functional impact of de­tected polymorphisms, particularly where these encode hypothetical proteins.

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Source: Behr Marcel A., Stevenson K., Kapur V. (eds.). Paratuberculosis: Organism, Disease, Control. 2nd edition. — CAB International,2020. — 439 p.. 2020
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