Hemotropic Mycoplasma Infections
Mycoplasma (Eperythrozoon) coccoides is naturally transmitted by the louse Polyplax serrata, but both the infection and the vector are essentially nonexistent in laboratory mice.
The organism is not transmitted trans- ovarially and is not transmitted by other mouse arthropods. With Giemsa and Romanowsky stains, the organism can be found attached to erythrocytes as well as free in the plasma of peripheral blood. In early infection, a high level of parasitemia occurs within a few days, with clinical signs ranging from inapparent to severe anemia and death. Splenomegaly is a prominent feature of this infection, and this organ plays a central role in clearance of the parasite from the blood. Although infection is persistent, mice eventually recover. Wild mice may also be infected with a related hemotropic Mycoplasma, M. haemomuris (previously Hemobartonella muris), which typically infects rats.
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