Ketamine-Xylazine Corneal Lesions

Corneal lesions have been observed in rats anesthetized with injectable ketamine-xylazine. Changes were attrib­uted to drug-induced vasoconstriction of the ciliary and iridial vessels, and subsequent corneal hypoxia, corneal opacity, mineralization of the anterior limiting mem­brane of the cornea, and corneal ulceration.