Lysosomal enzymes

Lysosomal enzymes contained within leukocyte granules are very important immune mediators and are critical for the removal of pathogens and cellular debris. Each leukocyte cell type contains slightly different lysosomal enzymes. Important enzymes in mast cells include chymase and tryptase. Neutrophils contain myeloperoxidase, defensins, elastase, lactoferrin, and many proteases. Eosinophils and basophils have major basic protein, which is important for antiparasitic defense mechanisms. Macrophages contain β-glucuronidase, β-galactosidase, acid hydrolases, and many other mediators.