Male Aggression
Adult male mice that are cohoused in a cage will fight unless reared as siblings or peers from infancy. Aggressive behavior is especially high among DBA, Swiss (CD-1, SJL, FVB), and BALB/c male mice.
Female aggression is less of a problem but varies with reproductive state and strain. The olfactory cues of a stable environment are drastically destabilized with cage changing, which is notorious for stimulating aggressive behavior among its occupants. Fight wounds can be diffuse (Fig. 1.96) but are often oriented around the tail and external genitalia. Severe trauma to the penis can result in obstructive uropathy.
FIG. 1.96. Multifocal cutaneous excoriations on the dorsal lumbar region of a pugilistic male BALB/c mouse.
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