Mixing Drugs
Some nonototoxic medications can safely mix with dimethyl sulfoxide (DMSO) to enhance penetration of the drug into tissues. Enrofloxacin injectable (Baytril, Bayer) is frequently mixed with DMSO/fluocinolone (Synotic, Ft. Dodge) to treat otitis externa or media in the dog. However, mixing a known ototoxin with the non- ototoxic DMSO may potentiate the ototoxicity. Mixing the aminoglycoside drugs with DMSO may enhance their absorption into the inner ear and may increase the toxicity of the medication.15
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