Other Gram-Positive Bacterial Infections Aerococcus viridans Infection
Aerococcus viridans is a facultative anaerobic bacterium that is present in the environment and may be isolated from human skin. It is a known opportunistic pathogen in immunosuppressed humans.
It has been associated with an outbreak of septicemia in immunodeficient NOD/SCID mice in Denmark. The mice developed pulmonary and hepatic abscesses and peritonitis following xenotransplantation of human tissues. Affected animals had weight loss, dyspnea, and distended abdomens. A similar syndrome has been noted by the authors in a U.S. colony of immunodeficient NSG mice, underscoring the propensity of this otherwise commensal organism to be an opportunistic pathogen. Infection was characterized by massive overgrowth of the bacteria (Fig. 1.72), with variable degrees of inflammation, which may be negligible in some tissues.
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