Tumors of skeletal muscle
Tumors arising from skeletal muscle are uncommon. Rhabdomyosarcomas reportedly make up less than 1% of tumors in domestic animals; in dogs, many of the reports involve young animals (Ginel et al., 2002).
Normal striated skeletal muscle does not exfoliate easily, and aspirates of tumors of musculoskeletal origin also may be contaminated with peripheral blood, of low cellularity, and nondiagnostic. The cytologic features of rhabdomyosarcoma samples are not easily distinguishable from other sarcomas (described above). The cells may have subtle striations within the cytoplasm, but these are often absent or difficult to find. ‘Strap cells’ or ‘strap-like cells’ are multinucleated cells in which the nuclei are arranged in a linear fashion within the cytoplasm. This cellular morphology is sometimes associated with rhabdomyosarcomas, but it is not a pathognomonic feature and may occur with other tumor types, as well.
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