Summary and conclusion
Systemic therapy in gynaecological cancer is being reshaped as a result of an evolving understanding of the biology of cancer development, progression, and resistance. This also allows for the constant re-evaluation of long-established therapeutic platforms and paradigms as a means of challenging not only dogma, but also to separate treatments that are standard but ineffective, and to retain therapies that are effective and evidence informed.
It is requisite to base treatment decisions that directly impact patients upon sound evidence from well-designed clinical trials, and shy away from logical but unsubstantiated therapies. This is an area of rapid change with tremendous promise for development of precision therapeutics, and the reader should assess updated information from validated national and international peer-reviewed guidelines on therapy to appropriately incorporated targeted agents into standard therapy (e.g. GCIG, NICE, NCCN).
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