Dystrophic Myopathies
Muscular dystrophies are debilitating myopathic disorders that present with muscle wasting and diffuse muscle weakness. They are caused by genetic mutations, which produce muscle fiber necrosis and regeneration, ultimately resulting in muscle fiber loss.
Traditionally, patients with the muscular dystrophies were grouped together because they had similar pathologies, and they were subdivided into categories based upon their modes of inheritance, ages of onset, and distributions of affected muscles. Most types of muscular dystrophy are not purely muscle disorders, but multisystem disorders with disease manifestations in a variety of body systems, which may include the musculoskeletal, cardiovascular, pulmonary, and gastrointestinal systems, as well as endocrine system, skin, eyes, brain, and other organ systems. Muscular dystrophies are caused by mutations of the genes encoding for proteins important for the stability of the sarcolemmal membrane and the maintenance of muscle fiber intracellular homeostasis. They are genetically, biochemically, and clinically diverse diseases.
More medical literature on Medic.Studio
More on the topic Dystrophic Myopathies:
- Dystrophic Myopathies
- Physical Examination
- TECHNICAL FACTORS OF NEEDLE ELECTROMYOGRAPHY
- Peripheral Vascular Disease
-
Infectious diseases -
Internal diseases -
Obstetrics and Gynaecology -
Pediatrics -
Veterinary medicine -
-
Conflictology -
Ecology -
Economy -
Finance -
History -
Law -
Medicine -
Philosophy -
Religious studies -