Conclusion
The studies reported in this chapter provide evidence for differences in disease prevalence between breeds and family lines in cattle, sheep, goats and deer, supporting the hypothesis that there is a genetic influence on host susceptibility to MAP infection.
While there has been limited validation of loci across studies, the identification of candidate genes across species suggests that there are common mechanisms influencing host susceptibility. In order to reduce disease prevalence through genomic selection a standardization of phenotypes through a standardized diagnosis of paratuberculosis is needed. The continued characterization of host susceptibility to MAP infection across species will allow for better understanding of the biological mechanisms behind the disease and allow for development of selection tools to help decrease its prevalence in domesticated livestock.References
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