Contents

Contributors vii

Preface ix

Marcel A. Behr Karen Stevenson and Vivek Kapur

1 Epidemiology, Global Prevalence and Economics of Infection 1

Jamie Imada, David F Kelton and Herman W Barkema

2 Mycobacterium avium subsp.

Foods and the Environment 14

Irene R. Grant

3 Paratuberculosis and Crohn's Disease 29

Shannon C. Duffy and Marcel A. Behr

4 Genetics of Host Susceptibility to Paratuberculosis 45

Holly L. Neibergs and Jennifer N. Kiser

5 Mycobacterium avium Complex 64

Christine Y Turenne and David C. Alexander

6 Comparative Genomics and Genomic Epidemiology of Mycobacterium

avium subsp. paratuberculosis Strains 76

Karen Stevenson and Christina Ahlstrom

7 Molecular Genetics of Mycobacterium avium subsp. paratuberculosis 92

Govardhan Rathnaiah, Fernanda M. Shoyama, Evan P. Brenner, Denise K. Zinniel,

John P, Bannantine, Srinand Sreevatsan, Ofelia Chacon and Raul G. Barletta

8 Proteins and Antigens of Mycobacterium avium subsp. paratuberculosis 104

John P. Bannantine and Vivek Kapur

Host-Pathogen Interactions and Intracellular Survival of Mycobacterium avium subsp. paratuberculosis

Paul Coussens, Justin L. DeKuiper, Fernanda M. Shoyama, Evan Brenner, Elise A. Lamont, Edward Kabara and Srinand Sreevatsan

Drug Susceptibility Testing and Antimicrobial Resistance in Mycobacterium avium subsp. paratuberculosis

Jaryd R. Sullivan and Marcel A. Behr

Paratuberculosis in Cattle

Marie-Eve Fecteau

Paratuberculosis in Sheep

Douglas Begg and Richard Whittington

Paratuberculosis in Goats

Kari R. Lybeck, Girum T Tessema, Annette H. Kampen, Berit Djonne and

Angelika Agdestein

Paratuberculosis in Deer, Camelids and Other Ruminants

Rory O'Brien, Colin Mackintosh and Frank Griffin

Infection of Non-Ruminant Wildlife by Mycobacterium avium subsp. paratuberculosis

Naomi J. Fox, Lesley A. Smith, Karen Stevenson, Ross S. Davidson, Glenn Marion and Michael R. Hutchings

Experimental Animal Models of Paratuberculosis

Adel M. Talaat, Chia-wei Wu and Murray E. Hines II

Immunology of Paratuberculosis Infection and Disease

Judith R. Stabel, Ad Koets and Kumudika de Silva

Cultivation of Mycobacterium avium subsp. paratuberculosis

Richard Whittington

Diagnosis of Paratuberculosis by PCR

Karren M. Plain, Ian Marsh and Auriol C. Purdie

Immune-Based Diagnosis of Paratuberculosis

Soren Saxmose Nielsen

Paratuberculosis Control Measures

Karsten Donat, Susanne Eisenberg and Richard Whittington

Paratuberculosis Vaccines and Vaccination

Ramon A. Juste, Joseba M. Garrido, Natalia Elguezabal and Iker A. Sevilla

Development of New Paratuberculosis Vaccines

Tim Bull