Future Perspectives

What is next for MAP proteomic research? The genome is sequenced and proteome has been defined. We now know all the ‘players' and in multiple studies, we have tested them at least from a diagnostic standpoint.

In many cases, we now know which antigens not to focus on! And that, at least, is some progress. However, very few proteome fractions or subunit proteins have been tested as vaccines and thus there is excellent opportunity for future successes. Animal models have been established, but the cost of using them is a likely reason so few studies have been conducted in this area. When one looks across the chronic bacterial disease landscape, it doesn't appear as though other diseases have had much success with vaccination or diagnostics, although many excellent studies have been conducted with these specific goals. Many of these diseases boast considerably more funding than that dedicated to paratuberculosis. Therefore, researchers in this field must remain creative and visionary to solve the problem of this slow, intractable disease.

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Source: Behr Marcel A., Stevenson K., Kapur V. (eds.). Paratuberculosis: Organism, Disease, Control. 2nd edition. — CAB International,2020. — 439 p.. 2020

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