Project assistance

Study.Sci.House ©

study@sci.house
 <<
↑
>>

Introduction

In order to reduce the prevalence of Mycobacterium avium subspecies paratuberculosis (MAP) infection and the associated costs of the disease, a better un­derstanding of the mechanisms behind the disease and the underlying genetic variation contributing to host susceptibility is needed.

Given that the dis­ease is currently contagious and difficult to iden­tify, selection for animals that are less susceptible to MAP infection would be a valuable tool for produc­ers to reduce disease and economic losses and en­hance biosecurity. Ideally, genomic selection would provide tools that would be useful within and across breeds. The identification of causal muta­tions in one species provides the opportunity to de­termine if the same mutations are responsible for MAP susceptibility in other species. Most genetic studies have focused on MAP susceptibility in cat­tle, sheep, goats and deer. This chapter focuses on reviewing new research published on host suscep­tibility of domestic ruminants to MAP infection.

location. This range of herd-level infection of MAP could be influenced by a variety of factors including differences between diagnostic tests, herd manage­ment and subspecies (Bos taurus, Bos indicus) and breeds of cattle being tested. Predominantly Zebu (Bos indicus) cattle have a higher number of herds positive for MAP (59.3%) compared with herds composed of crossbred Bos taurus ? Bos indicus (31.6%) or European (Bos taurus) breeds (28.9%) in Brazil (Vilar et al., 2015). A large Canadian dairy study tested breed susceptibility to MAP infection in Jersey and Guernsey cattle compared with Holstein and Brown Swiss cattle. In this study, the odds of Jersey and Guernsey cattle testing positive for MAP using a milk enzyme-linked immunosorbent assay (ELISA) test were 1.4 to 8.3 times higher than in Holsteins or Brown Swiss cattle (Sorge et al., 2011). In addition to studies investigating differences in breed susceptibility, heritability studies also provide estimates of non-environmental factors associated with disease susceptibility. For an in-depth review of estimated herd-level and animal-level prevalence of MAP, please see Chapter 1 of this volume.

4.2

<< | >>
↑
Source: Behr Marcel A., Stevenson K., Kapur V. (eds.). Paratuberculosis: Organism, Disease, Control. 2nd edition. — CAB International,2020. — 439 p.. 2020
More medical literature on Medic.Studio

More on the topic Introduction:

  1. 1 Introduction
  2. Introduction
  3. Introduction
  4. 19 Introduction
  5. Introduction
  6. Introduction
  7. INTRODUCTION
  8. Introduction
  9. Introduction
  10. Introduction
  11. Introduction
  12. Introduction: Hegel, Marx and the Dialectic
  13. INTRODUCTION: OVERVIEW OF COMPLICATIONS ASSOCIATED WITH HIV THERAPY
  14. Introduction
  15. Introduction
  16. Introduction
  17. Introduction
  18. Introduction
  19. INTRODUCTION
- Infectious diseases - Internal diseases - Obstetrics and Gynaecology - Pediatrics - Veterinary medicine -
- Conflictology - Ecology - Economy - Finance - History - Law - Medicine - Philosophy - Religious studies -

Study.Sci.House ©

study@sci.house