CONTENTS
Introduction................................................................................................................................... 335
The Apoptotic Machinery in Thymocytes....................................................................................
336Role of Apoptosis in T Cell Development.................................................................................... 337
Death by Neglect.................................................................................................................... 337
Negative Selection................................................................................................................. 338
Impact of HIV Infection on Thymic Function.............................................................................. 339
Alteration of Thymic Output after HIV Infection................................................................. 339
Several Thymocyte Subsets Are Susceptible to HIV Infection............................................ 340
Modulation of Apoptosis in the Thymuses of Infected Individuals............................................ 341
Influence of HIV on Thymocyte Apoptosis Rate................................................................... 341
Apoptosis in the Thymic Stroma........................................................................................... 342
Mechanisms Involved in the Modulation of Apoptosis by HIV in the Thymus.......................... 342
Role of Cytokines in HIV-Mediated Perturbation of Thymocyte Apoptosis........................ 342
Influence of IL-7 Levels......................................................................................................... 342
Role of TNF-α........................................................................................................................
343Perturbation of Thymic Function by IFN-α.......................................................................... 343
Influence of IL-10................................................................................................................... 344
Role of Glucocorticoids......................................................................................................... 344
Role of the CD95/Fas Pathway.............................................................................................. 344
Role of HIV Proteins in Thymic Apoptosis Modifications................................................... 345
Concluding Remarks..................................................................................................................... 345
Acknowledgments......................................................................................................................... 345
References..................................................................................................................................... 346
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