Index

A

AA amyloid

guinea pig, 243

mouse, 92

AapoAII amyloid, mouse, 92 abortion

guinea pig

Chlamydophila caviae, 224

equine herpesvirus 1, 220

Listeria monocytogenes, 226

Streptococcus equii subsp.

Streptococcus pneumoniae, 230

mouse

Pasteurella pneumotropica, 65

Streptobacillus moniliformis, 67

rabbit

leporid herpesvirus 4, 258

Listeria monocytogenes, 280, 281

Pasteurella multocida, 284

pregnancy toxemia, 313

Salmonella enterica, 285

vitamin A deficiency, 314

rat, Rat Virus (RV), 124

abscesses

gerbil, nasal dermatitis, 206

guinea pig

Brucella spp., 223

Streptobacillus moniliformis, 229

Streptococcus equi subsp. Zooepidemicus, 229

Streptococcus pneumoniae, 230

Streptococcus pyogenes, 230

hamster, 186

mouse

Aeroccus viridans, 67

Corynebacterium kutscheri, 69

Klebsiella spp., 62

Mycoplasma pulmonis, 64

Pasteurella pneumotropica, 65

Stapylococcus spp., 69-71

Streptobacillus moniliformis, 67

Streptococcus equisimilis, 72

rabbit

Actinobacillus spp., 271

Actinomyces spp., 271 Corynebacterium bovis, 273 Fusobacterium necrophorum, 279 Pasteurella multocida, 283-285 Staphylococcus aureus, 285-286 tooth, 309

rat

Actinomyces bovis, 186

Corynebacterium kutscheri, 140-141

Klebsiella pneumoniae, 142 Mycoplasma pulmonis, 135-136 Pasteurella pneumotropica, 143 Pseudomonas aeruginosa, 143 Staphylococcus aureus, 144 Streptobacillus moniliformis, 144 Streptococcus spp., 186 acariasis

Demodex spp.

gerbil, Demodex meriones, 205 guinea pig, Demodex caviae, 238 hamster

Demodex aurati, 191

Demodex criceti, 191 mouse

Demodex flagellarus, 87

Demodex musculi, 87

rabbit, Demodex cuniculi, 303 rat

Demodex nanus, 154

Demodex norvegicus, 154

Demodex ratti, 154

Demodex ratticola, 154

follicle mites

mouse, Psorergates simplex, 87 free-living (blood sucking) mites gerbil

Acarus farris, 205 Lipponyssoides sanguineus, 205 Tyrophagus castellani, 205

Pathology of Laboratory Rodents and Rabbits, Fourth Edition.

© 2016 John Wiley & Sons, Inc. Published 2016 by John Wiley & Sons, Inc.

acariasis (Continued )

guinea pig, Acarus farris, 238 hamster

Ornithonyssus bacoti, 191

Ornithonyssus sylviarum (northern fowl mite), 191 rabbit

Dermanyssus gallinae (red poultry mite), 304 Trombicula spp., 303-304

rat

Ornithonyssus bacoti (tropical rat mite) 154 Laelaps echidnina (spiny rat mite), 154 Lipponyssoides spp. (house mouse mite), 154 fur mites

guinea pig, Chirodiscoides caviae, 237

mouse

Myobia musculi, 86-87

Myocoptes musculinus, 86-87

Rhadfordia affinis, 86-87

Rhadfordia ensifera, 86-87

Trichoecius rombusti, 86

rabbit

Cheyletiella parasitovorax, 302-303

Leporacarus gibbus, 303

rat, Rhadfordia ensifera, 153

mange mites

guinea pig

Notoedres muris, 238

Psoroptes cuniculi, 238

Sarcoptes scabei, 238

Trixacarus caviae, 237-238

hamster, Notoedres notoedres, 191, 192

rabbit

Notoedres cati, 303

Psorobia lagomorpha, 303

Psoroptes cuniculi, 303

Sarcoptes scabei, 303, 304

rat, Notoedres muris, 154

nasal mite

hamster, Speleorodens clethrionomys, 191 accessory sex glands

guinea pig, 216

hamster, 174

mouse, 8

neoplasia, 115

Acholeplasma sp., guinea pig, 227-228

acid fast bacteria, intestinal (Mycobacterium avium paratuberculosis), rabbit, 282

Acidophilic Macrophage Pneumonia (AMP), mouse, 3, 94-95, 100

Acinetobacter calcoacetis, bronchopneumonia, rabbit,

271

Actinobacillus muris, mouse 65

Actinobacillus spp., rabbit, 271

Actinomyces bovis, hamster, 186

Actinomyces spp.

mouse, 79

rabbit, 271

adenomatous intestinal hyperplasia (Lawsonia), guinea pig, 226

adenomyosis, mouse, 104

adenovirus, intestinal

hamster, 175

mouse, Murine Adenovirus (MAdV-1, MAdV-2), 14-15,

95

rabbit, 257-258

rat, 121-122

adenovirus, respiratory, Guinea Pig Adenovirus (GPAdV-1), 218-219

adrenal gland

gerbil, 200

hamster, 174

mouse, 8-9

accessory, 8

adenovirus-infected, 14

spindle cells, 9

x zone, 9

rat, 120

adrenocortical tumors

gerbil, 210

guinea pig, 252

hamster, 193, 198

mouse, 117

AEEC, see Attaching and Effacing E.

Age-Dependent Poliomyelitis (ADPM), mouse, 26 agouti mouse, 3

AKR mouse, 22, 26, 33, 51, 102

lymphoma, 108, 110 retroelements, 40, 41, 42, 43 albino mouse, 3

Tyr retroelement integration, 41 albino rat, 119, 121, 161 alopecia

gerbil

barbering, 206

nasal dermatitis, 206 staphylococcal dermatitis, 203-204

guinea pig, 245

acariasis 237-238

cystic rete ovarii, 245, 249

exfoliative dermatitis, staphylococcal, 228 dermatophytosis, 234

pediculosis, 238

Peloderma strongyloides, 237

hamster

epidermotrophic lymphoma, 198

Cushing's-related, 193

mouse

acariasis, 86

B6 mice, 3, 90-91, 96

barbering, 90-91, 96

clown mouse syndrome, 96

Corynebacterium bovis, 68

dermatophytosis, 78

mechanical, 95

poxvirus, 22

reovirus, 36 staphylococcal dermatitis, 143-144 rabbit

acariasis, 302-304

behavioral, 253

exfoliative dermatosis, 309

alopecia areata, C3H mouse, 96

alveolar hemorrhage, mouse, agonal, 6, 100

alveolar histiocytosis

hamster, 196

mouse, 6, 100

pneumocystosis, 79-80

rat, 155

pneumocystosis, 147

alveolar proteinosis, mouse, 6, 100

alveolitis

mouse

Mouse Norovirus (MNV), STAT1 null mouse, 31

Mycoplasma pulmonis, 64

Pneumonia Virus of Mice (PVM), 32

Sendai virus, 33-35

rabbit, Pasteurella multocida, 284

rat

Pneumonia Virus of Mice (PVM), 128

Sialodacryoadenitis Virus (SDAV), 127 amyloid-like nasal deposition, mouse, 92-93 amyloidosis gerbil, 208, 210 guinea pig

pododermatitis, 228

systemic, 243-244

hamster, 194

atrial thrombosis, 194

Giardia muris, 189

glomerulonephropathy, 196

mouse, 92-93

atrial thrombosis, 99, 100

Staphylococcus aureus, 71, 96

strain predilection, 3-4

rabbit, 311-312

amyloid P, hamster, 194

Amyotrophic Lateral Sclerosis (ALS) model, mouse 26 anatomic features, see gerbil; guinea pig; hamster; mouse; rabbit; rat

anisocytosis

hamster, 174

mouse, 6

rabbit, 255

anophthalmia, B6 mouse, 3, 99 anorectal impaction, guinea pig, 247 anorectal polyps, rabbit, 308 antibiotic toxicity

gerbil

enterocolitis, 201

streptomycin toxicity, 208

guinea pig, enterotoxemia, 224-225

hamster, enterotoxemia, 180-181

rabbit, enterotoxemia, 273-275, 316 antibodies, maternal

guinea pig, 215

mouse, 10, 13

rabbit, 255, 256

aortic cartilage, mouse, 10

appendix, rabbit, 255

arenavirus, see Lymphocytic Choriomeningitis Virus (LCMV)

arteritis

mouse

polyarteritis, 99

renal infarction, 103

vestibular syndrome, 98

rat, polyarteritis nodosa, 156 arterivirus, see Lactate Dehydrogenase-elevating Virus (LDV)

arthritis/polyarthritis (septic)

guinea pig, 246

Streptococcus equi subsp.

Streptococcus pneumoniae, 230 mouse

Corynebacterium kutscheri, 69

Mycoplasma spp., 63, 64

Streptobacillus moniliformis, 67

rat, 159

Erysipilas rhusiopathiae, 141

Mycoplasma spp., 134, 135

Streptobacillus moniliformis, 144 arthropods, see Acariasis; Pediculosis; Fleas; Myiasis arthropathy, fluoroquinalone/enrofloxicin, rabbit, 316 Aspergillus spp.

mouse, 79

rabbit, 292

rat, 145

Aspiculuris tetraptera, see Helminth infestations, pinworms aspiration pneumonia

mouse, 100

rat, quality of bedding, 162

astrovirus

mouse, 26-27

rabbit, 264

rat, 129 atherosclerosis/hypercholesterolemia rabbit, 314

Chlamydophila pneumoniae, 272 atrial (auricular) thrombosis mouse, 3, 99, 100

alopecia of B6 mice, 96

amyloidosis, 93

clostridial enteropathy, 52

glomerular disease, 102

hamster, 194-195

amyloidosis, 194 atrophic rhinitis, rabbit, Pasteurella multocida, 283-284

atrophy

guinea pig, glomerular, nephrosclerosis, 248 hamster, pressure, polycystic liver disease, 195-196 mouse

gastric, Helicobacter muridarum, 5 7

seminal vesicular, 104

tubular, NSAIDS-associated nephropathy, 103 rat

hepatic cords, 120

myocardial degeneration/fibrosis, 155

skeletal muscle, radiculoneuropathy, 154

Attaching and Effacing Escherichia coli (AEEC) mouse, 50

rabbit, 277-278 audiogenic seizures, mouse, 97 auditory bullae, gerbil, 200 aural cholesteatoma, gerbil, 207

auricular chondritis/chondropathy

mouse, 96

rat, 159-160

auricular thrombosis. see atrial (auricular) thrombosis

B

bacterial infections

gerbil, 201-204

guinea pig, 222-231

hamster, 180-186

mouse, 50-72

rabbit, 271-288

Bacteroides

hamster, 180

rabbit, 254

BALB/c mouse, 3

amyloid, tumor-associated, 92

auricular (atrial) thrombosis, congestive heart failure, 99 cardiac calcinosis, 93

conjunctivitis, blepharitis, 98

epicardial mineralization, 93 glomerulonephritis, 102 Harderian gland tumor, 114 hepatocellular lipidosis, 95 hypocallosity, 97 lymphoma, 42, 108, 109, 110 mucometra, 103 myoepithelioma, 114 plasmacytoma, 110 pugilism, 90 pulmonary adenoma, 92, 112 renal cysts, 103 Reye's-like syndrome, 95 rhabdomyosarcoma, 115, 116 balloon cells, intestine, Mouse Hepatitis Virus (MHV), 29, 30 barbering

gerbil, 206

guinea pig, 245

mouse, 90-91

B6, 3, 96

foreign body periodontitis, 100

rabbit, 308

basophil

rabbit, 255

rat, 119

Baylisascaris spp.

guinea pig, 237

rabbit, 300-301

B-cell

gerbil

lymphoma, 210

mouse

deficient, 11

lymphoma, 42-43, 109-110

rabbit

GALT, 255

lymphoma, 320-322

bedding

guinea pig

anorectal impaction, 247

foreign body pneumonia, 245-246

hamster, dermatitis, 196

mouse

aspiration pneumonia, 100 cotton wool, 97

rat

hardwood, 161

quality, 162

behavioral disorders and diseases

guinea pig, 245

alopecia, 245

barbering or ear chewing, 245

sexual behavior, ovarian cysts, 249

mouse, 89

alopecia of B6 mice, 96

barbering, 90-91

infertility, 89-90

male aggression, 90

penis self-mutilation, B6 mice, 91

stereotypy, 90

behavioral features

gerbil, 199

guinea pig, 213-214

hamster, 173

rabbit, 253-254

rat, 119

beige mouse, NK-deficient, 11, 16

beige rat, NK-deficient, 143

beta hemolysin, streptococcal, 71

bezoar, gastric and intestinal, rabbit, 307, 308 bicornuate uterus, rabbit, 256, 257 bile canuliculi, mouse, Helicobacter, 56-57 bile duct adenoma/adenocarcinoma, rabbit, 322 bile ductular hyperplasia

guinea pig, chronic idiopathic cholangiofibrosis, 247 hamster

Helicobacter, 182

hepatic cirrhosis, 196 polycystic liver disease, 195-196 mouse, 101

Helicobacter, 57

rabbit, 308

Capillaria hepatica, 301

Eimeria stiedae, 298-300

rat, 157

Bittner agent (MMTV-S), mouse 39, 42

bladder threadworm (Trichosomoides crassicauda), rat,

152

bladder, urinary

guinea pig, 216

Corynebacterium renale, 226 cystitis and urolithiasis, 248-249 mouse

copulatory plug, 8 urologic syndrome (MUS), 104 rabbit, 256

urolithiasis, 310, 311

rat

copulatory plug, 159

Trichosomoides crassicauda, 152-153 urolithiasis, 158-159 blepharitis/conjunctivitis

guinea pig, 224, 231

mouse, 3, 22, 69, 98-99

rabbit, 259, 262, 272, 283

rat, 161-162

blindness, mouse, 99

bloat

guinea pig, 246

mouse, Murine Adenovirus (MAdV-2), 15

rabbit

dysautonomia, 276

Epizootic Rabbit Enteropathy (ERE), 276 gastric dilation, 306-307

BN, see Brown Norway (BN) rat

bone

guinea pig hypovitaminosis C, 239-241 osseous metaplasia, 216

mouse, 10 fibro-osseous lesion, 105 Haversian bone, lack of, 9 neoplasms, 116 physeal plate closure, incomplete, 9

rabbit, 257

fluoride toxicosis, 315

nutritional secondary hyperparathyroidism, 314 rat, 120

bone marrow

guinea pig

cavian leukemia, 251

Kurloff cells, 214

osseous metaplasia associated, 216

mouse, 6 fibro-osseous lesions, 105 Mouse Hepatitis Virus (MHV), 27, 29 Minute Virus of Mice (MVM), 18 myeloid hyperplasia, 114 myeloid leukemia, 111 parvovirus, 18

rabbit

Eimeria stiedae, 298 fibroma virus, 263 lymphosarcoma, 321-322

Bordetella bronchiseptica

gerbil, 201

guinea pig, 222-223

rabbit, 271-272

rat, 132-133

Bordetella hinzii, mouse, 60

Borna virus/disease, rabbit, 264

botryomycosis

guinea pig, 228

mouse, 70

rat, 144

Bowman's capsule

gerbil, lamina muscularis, 200

guinea pig, diabetes mellitus, 243

mouse, cuboidal epithelium, 8, 9

rat, chronic progressive nephropathy, 157-158 brachygnathia, maxillary, rabbit, 318 Brachyspira spp.

mouse, 50

guinea pig, 223

brain

gerbil

cerebral ischemia, 200

vacuolation, (spongiosis), 207

guinea pig, nematode larval migrans, 237 hamster

cerebral mineralization, 196

Hamster Parvovirus (HaPV), 175-176 hydrocephalus, 197

spontaneous hemorrhagic necrosis of fetal hamsters, 193

mouse, 10, 98

cerebellar hypoplasia, 18

hydrocephalus, 98

hypocallosity, 97-98

Mouse Encephalomyelitis Virus (MEV), 35-36

Mouse Hepatitis Virus (MHV), 29, 30

seizures, post ictal neuronal necrosis, 97

thalamic mineralization, 98

vacuolation, (spongiosis), 98

rabbit, 255

Baylisascaris spp. larval migrans, 300-301

Encephalitozoon cuniculi, 293-295

rat

degenerative changes, 154

hydrocephalus, 160

Rat Virus (RV), 123-124 bronchitis/bronchiolitis/bronchopneumonia guinea pig

Bordetella bronchiseptica, 223

Guinea Pig Adenovirus (GPAdV-1), necrotizing, 218

Klebsiella pneumoniae, 226

Streptococcus pneumoniae, 230

mouse

Bordetella hinzii, 60

Mycoplasma pulmonis, 64

Pneumonia Virus of Mice (PVM), 32

Sendai virus, necrotizing, 34-35

rabbit

Bordetella bronchiseptica, 272

leporid herpesvirus 4, 258

myxoma virus, 263

Pasteurella multocida, 283, 284

Staphylococcus aureus, 285, 286

rat

Cilia Associated Respiratory (CAR) bacillus, 133-134 Mycoplasma pulmonis, 135-136

Sendai virus (necrotizing bronchiolitis), 128

Streptococcus pneumoniae, 145

Bronchus-Associated Lymphoid Tissue (BALT) mouse, 6 rat, hyperplasia, 128, 133, 135

brown fat

hamster, 174

mouse, 10

rat, 120

Brown Norway (BN) rat, 119

eosinophilic granulomatous pneumonia, 160 hydronephrosis, 159

renal papillary hyperplasia, 159

Bruce effect, mouse, 90

Brucella spp. (brucellosis)

guinea pig, 223

rabbit, 272

Brunner's glands, rabbit, 256

brush rabbit, myxoma virus, 261

B6 mouse, see C57BL/6 (B6) and C57BL/10 (B10) mouse buccal pouches, hamster, 174

bulbourethral gland

guinea pig, 216

mouse

cyst, 104

Pasteurella pneumotropica, 65

bumblefoot, guinea pig, 228

buphthalmia, rabbit, 318

Burkholderia gladioli, mouse, 60

Burkitt-like lymphoma, mouse, 110

C

cage lid closure injuries, mouse, 105 calcification (mineralization), soft tissue, mouse, 93 calcium metabolism/absorption/regulation

guinea pig, 214, 216, 242

rabbit, 254, 310-311, 313-314, 319

calculi, urinary, see urolithiasis

calicivirus

Mouse Norovirus (MNV), 31

Rabbit Hemorrhagic Disease (RHD) virus, European Brown Hare Syndrome (EBHS) virus, Rabbit Vesivirus, 264

Campylobacter spp.

guinea pig, 224

hamster, 180

rabbit, 272

rat, 136

Candida spp., mouse, 79

candidiasis, gastric, mouse, 79

cannibalism

guinea pig, 214

hamster, 173

mouse, 90

rabbit, 254

Capillaria hepatica

rabbit, 301

rat, 153

CAR bacillus, see Cilia Associated Respiratory (CAR) bacillus carbohydrate overload, rabbit, 273

cardiac calcinosis (mineralization), mouse, 93-94

cardiac glycogenosis, guinea pig, 241-242

cardiac valvular angiectasis, rat, 156 cardiomyopathy

gerbil, hyperadrenocortism, 207-208

rabbit

coronavirus, 267

ketamine/xylazine toxicity, 316

rat, myocardial degeneration/fibrosis, 155 cardiovascular disease of breeding gerbils, 207 cardiovascular system

gerbil, hyperadrenocortism, 207-208

guinea pig

glycogenosis (rhabdomyomatosis), 241-242 myocardial degeneration, 241

neoplasia, 252

hamster, atrial thrombosis, heart failure, 194-195 mouse

atrial thrombosis, 99, 100

calcinosis, 93-94

heart failure, 99

polyarteritis, 98, 99

rabbit, atrioventricular valve anatomy, 255 rat

cardiac valvular angiectasis, 156

myocardial degeneration/fibrosis, 155 polyarteritis nodosa, 156 caries (dental)

gerbil, 206-207

hamster, 196

cataract

mouse, 4

rabbit, 318

Encephalitozoon, 295

rat, phototoxic, 161

catarrhal enterocolitis, mouse, Citrobacter rodentium, 50 caudate nucleus, spongiosis, gerbil, 207

Cavia aperea, C. fulgida, C. tschudii, 213

Cavia porcellus (guinea pig), 213

cavian leukemia, guinea pig, 251

cecal appendix, rabbit, 255

cecal impaction, rabbit, 307

cecal microbiome, rabbit, 254

cecal mucosal hyperplasia, hamster, 181

cecal tonsil, rabbit, 255

cecal volvulus, guinea pig, 247 cecotrophy

guinea pig, 216

rabbit, 254

Eimeria spp., 298

cecum

guinea pig, 216

enterotoxemia, 225

Listeria monocytogenes, 227

volvulus, 247

Yersinia pseudotuberculosis, 231

hamster, 174

enterotoxemia, 181

Giardia muris, 189

Helicobacter, 182-183

mucosal hyperplasia, 181

mouse

Citrobacter rodentium, 52

Helicobacter hepaticus, 56

Tritrichomonas muris, 82

rabbit

anatomy, 255, 256

Campylobacter spp., 272

coliform enteritis, 274, 275

enterotoxemia, 274-275 pinworms, 301

Tyzzer's disease, 275

rat, pinworms, 152

central nervous system. see nervous system cerebellar hypoplasia

hamster, 175

mouse, Minute Virus of Mice (MVM), 18

rat, Rat Virus (RV), 124

cerebral hemorrhage

hamster

Hamster Parvovirus (HaPV), 176

spontaneous hemorrhagic necrosis, fetal, 193

rat, Rat Virus, 123

cerebral ischemia, gerbil, 200

cerebral mineralization, hamster, 196

cervical lymphadenitis

guinea pig

Streptobacillus moniliformis, 229

Streptococcus equi subsp. Zooepidemicus, 229-230 mouse

Staphylococcus aureus, 70

Streptobacillus moniliformis, 67

C57BL/6 (B6) and C57BL/10 (B10) mouse, 3, 10

acidophilic macrophage pneumonia, 94

alopecia, 96

amyloidosis, late onset, 92

cochlear degeneration, 98

dermatitis, ulcerative, 70, 90

epithelial hyalinosis, 94, 101

glomerulonephritis, 102

hemangiosarcoma, 3

hydrocephalus, 98

IgG2c, 10

lymphoma, 109

malocclusion, 100

melanosis, visceral, 9, 10 microphthalmia/anophthalmia, 98, 99 mucometra, 103

Murine Mammary Tumor Virus (MMTV) resistance, 112 muscular dystropy, C57BL/10ScSn mouse, 105 neurodegeneration, hippocampus, 3

penis self-mutilation, 91

pituitary adenoma, 116

seminal vesicular dilation/atrophy, 104, 105

tail trauma, necrosis, 90

TLR4 deficiency, C57BL/10ScN mouse, 11 trichotillomania, 96

cheek pouches, hamster, 174

cheek teeth

guinea pig, 216

mouse, 6

foreign body periodontis, 100, 101

malocclusion, 246

rabbit, 256

malocclusion, 319

cheilitis

guinea pig, 246

rabbit, Treponema paraluis-cuniculi, 287

chemical mutagenesis

mouse, 4

cleft palate, 100

chimeric mouse, 4-5

Chinese hamster, 173, 174

diabetes mellitus, 193

Chinese letters (Corynebacterium kutscheri), 141

Chlamydia/Chlamydophila spp., mouse, 60-61

Chlamydophila caviae, conjunctivitis, guinea pig, 224

Chlamydophila psittaci, rabbit, 272

chloral hydrate ileus, rat, 162

chloroform toxicity, mouse, 103 cholangiofibrosis, idiopathic, guinea pig, 247 cholangioma/cholangiocarcinoma, mouse, 113, 114 cholesteatoma, gerbil, external ear canal, 207

Choriomeningitis, see Lymphocytic Choriomeningitis (LCMV)

choroid plexus

rabbit

adipocytes, 255

xanthomatosis, hypercholesterolemia, 314 chromodacryorrhea

rat

Sialodacryoadenitis Virus (SDAV), 125, 127 stress, 161

chronic idiopathic cholangiofibrosis, guinea pig, 247 chronic Progressive Nephropathy (CPN)

mouse, 102

rat, 157-158

chronic renal disease, guinea pig, nephrosclerosis, 247-248

chronic Respiratory Disease (CRD), rat, 133, 134-136 Cilia-Associated Respiratory (CAR) bacillus

gerbil, 201

mouse, 61, 63

rabbit, 272-273

rat, 125, 133-134

Mycoplasma pulmonis co-infection, 136 circle of Willis, incomplete, gerbil, 200 Citrobacter freundii

guinea pig, 224

mouse, 50

Citrobacter rodentium

gerbil, 201

mouse, transmissible murine colonic hyperplasia,

50-52

clawed jird, gerbil, 199

cleft lip/palate

mouse, 100

rabbit, hypervitaminosis A, 314

clostridial enteropathy/enterotoxemia

guinea pig, 224-225

hamster, 180-181

mouse, 52-53

rabbit, 273-275

rat, 136

Clostridium botulinum, dysautonomia, rabbit, 276

Clostridium difficile

gerbil, 201

guinea pig, 224-225

hamster, 180-181

mouse, 52

rabbit, 273-274

rat, 136

Clostridium perfringens

gerbil, 201

guinea pig, 224-225

mouse, 52-53

rabbit, 273, 276-277

Epizootic Rabbit Enteropathy, 276-277

Clostridium piliforme (Tyzzer's disease)

gerbil, 201-203

guinea pig, 225

hamster, 181-182

mouse, 53-54

rabbit, 275-276

rat, 137-138

Clostridium Spiroforme, rabbit, 273-274

clown mouse syndrome, 96

coagulum, mouse, 8

Murine Urologic Syndrome (MUS), 104 coccidiosis, enteric. see Cryptosporidium; Eimeria spp. coccidiosis, hepatic (Eimeria steidae), rabbit, 298-300 coccidiosis, renal

guinea pig, Klossiella cobayae, 236 mouse, Klossiella muris, 83

cochlear degeneration, mouse, 3, 98 colibacillosis, see enteritis colitis, see enteritis; enteropathy/enterotoxemia colitis cystica, mouse, 50, 108 colitis, hyperplastic

hamster, Helicobacter spp., 182, 183

mouse

Citrobacter rodentium, 50-52

Eimeria spp., 82-83

Helicobacter spp., 56-58

Mouse Hepatitis Virus (MHV), 27, 30

rat, Helicobacter spp., 139

complement (C5) deficiency, mouse, 11

congenital glaucoma, rabbit, 318

congestive heart failure

hamster, 194-195

mouse, amyloidosis, 93 conjunctivitis/blepharitis

gerbil, ocular proptosis, 207

guinea pig

bacterial, 231

Chlamydophila caviae (inclusion body conjunctivitis), 224

mouse, 98-99

Corynebacterium spp., 69

Pasteurella pneumotropica, 65, 66 strain predilection, 3

rabbit

Chlamydophila spp., 272

Herpes simplex virus, 259

Myxoma virus, 262

Pasteurella multocida, 283

Rabbit Hemorrhagic Disease (RHD) virus, 265 rat, 161

copper toxicosis, rabbit, 315

copra itch mite, gerbil, 205

coprophagy, see also cecotrophy

hamster, 174

mouse, 6

rabbit, 254

copulatory behavior, mouse, 90, 91

copulatory plug

mouse

agonal, 8

Murine Urologic Syndrome (MUS), 104

rat, agonal, 159

guinea pig, urethral obstruction, 249

corneal dystrophy, anterior, rabbit, 318

corneal lesions, rat, 162

corneal opacities

mouse, 98

strain predilection, 3

rabbit, congenital glaucoma (buphthalmia), 318

coronavirus

guinea pig, coronavirus-like virus, 220

Mouse Hepatitis Virus (MHV), 27-31

rabbit, 266-267

rat, Sialodacryoadenitis Virus (SDAV)125-127

corpus callosum aplasia/hypoplasia, mouse, 3, 97 Corynebacterium bovis

mouse, hyperkeratosis, 67-69

rabbit, abscesses, 273

Corynebacterium hoffmani, mouse, 69

Corynebacterium kutscheri (pseudotuberculosis)

guinea pig, 225

hamster, 185

mouse, 69

rat, 140-141

Corynebacterium mastitidis, mouse, 69

Corynebacterium pseudodiphtheriticum, mouse, 67

Corynebacterium pyogenes, guinea pig, 225

Corynebacterium renale, guinea pig, 226

Corynebacterium spp.

hamster, 185

mouse, 69

rat, 145

coryneform hyperkeratosis (Corynebacterium bovis), mouse, 67-69

cotton bedding fiber, sloughing of extremities, mouse, 97 Cottontail Rabbit Papilloma Virus (CRPV), 260 cow pie syndrome, megacolon-syndrome of spotted rabbits, 319

Cowpox Virus (CPXV), rat, 124-125

Coxiella burnetii, mouse, 61-62

CPXV, Cowpox Virus (CPXV), rat, 124

CRD, Chronic Respiratory Disease, rat, 133, 134-136 cre-lox technology, mouse, 4, 5

cre recombinase expression, mouse, hydrocephalus, 98 Cricetulus griseus, hamster, 173

Cricetulus migratorius, hamster 173

Cricetus cricetus, hamster, 173

CRPV, Cottontail Rabbit Papilloma Virus (CRPV), 260

Cryptococcus neoformans

guinea pig, 234-235

mouse, 79

cryptorchism, rabbit, 310

Cryptosporidium spp.

gerbil, 204-205

guinea pig, 235-236

hamster, 189

mouse, 82, 108

rabbit, 297

rat, 152

C3H mouse, 3

alopecia areata, 96

amyloidosis, 92

chloroform toxicity (renal tubular necrosis), 103

ear gangrene/notching, 96

hepatic tumors, 113-114

mammary tumors, 43, 111-112 mesenteric disease, 102

Murine Mammary Tumor Virus (MMTV), 42-44,

111, 112

myocardial degeneration, 3

myocardial mineralization, 93-94

retinal degeneration, 99

skeletal muscle mineralization, 93

tail trauma, 90

TLR4 deficiency, C3H∕HeJ mouse, 11

ulcerative dermatitis, 70

Cushing's-like syndrome

guinea pig, 252

hamster, 193

cutaneous abscesses, hamster, 186

cutaneous excoriation, mouse, 90

cutaneous hyperpigmentation, hamster, 193 cutaneous neoplasia

gerbil, B-cell lymphoma, 210

guinea pig, trichoepithelioma∕trichofolliculoma, 250 hamster

lymphoma, 198 trichoepithelioma, 177

rabbit

lymphoma, 322 myxomas, 263, 264 papillomas, 260 rat, lymphoma, 167 cystic endometrial hyperplasia

guinea pig, 249

mouse, 104

rabbit, 310, 320

Cysticercus spp.

hamster, 190

mouse, 85

rabbit, 302

rat, 153

cystic mastitis, rabbits, 313, 322

cystic ovaries (cystic rete ovarii)

gerbil, 208

guinea pig, 249

cystitis

guinea pig

Escherichia coli, 226

urolithiasis, 248

mouse, Murine Urologic Syndrome (MUS), 104

rabbit, 256

rat

pyelonephritis associated, 145 urolithiasis,159 cytomegalovirus

Guinea Pig Cytomegalovirus (GPCMV), 219

Hamster Cytomegalovirus (Cricetid herpesvirus, CrHV-1), 175

Mouse Cytomegalovirus (MCMV), 15

Rat Cytomegalovirus (RCMV), 122 cytomegaly

guinea pig, 219

hamster, 175

mouse, 7, 16, 57, 101, 114

rat, 122

D

dacryoadenitis, rat, 125-127

Dalila effect, mouse, barbering, 90

DBA mouse

amyloidosis, 92

audiogenic seizures, 97

cardiac calcinosis, 93-94

chloroform toxicity, 103 hepatocellular neoplasia, 113 male aggression, 90 degenerative disorders

gerbil

chronic glomerulonephropathy, 208

focal myocardial degeneration, 207

obesity and diabetes, 207

spongiosis of the caudate nucleus, 207 guinea pig

cardiac glycogenosis, 241

chronic idiopathic cholagiofibrosis, 247 myocardial and skeletal muscle degeneration with mineralization, 241

nephrosclerosis, 247-248

nutritional myopathy, 241

osteoarthritis, 246

hamster

glomerulonephropathy, 196

hepatic cirrhosis, 196

mouse, 91

chronic nephropathy, 102

cochlear degeneration, 98

muscular dystrophy, 105

NSAIDS-associated nephropathy, 103 osteoarthritis, 105

polyarteritis, 99

retinal degeneration, 99

soft tissue calcification, 93-94

vertebral disk degeneration, 105

rabbit

degenerative spinal disease, 309-310

rat

chronic progressive nephropathy, 157-158 myocardial degeneration/fibrosis, 155 nervous system, 154

osteoarthritis, 159

polyarteritis nodosa, 156

radiculoneuropathy, 154-155 dehydration

mouse, 91-92

rat, hydrocephalus, 160, 161

demes, mouse, 89

Demodex, see acariasis

demyelination

mouse

Mouse Encephalomyelitis Virus (MEV), 35-36

Mouse Hepatitis Virus (MHV), 29

rat

age related, 154

radiculoneuropathy, 154

dental caries, see caries

dermatitis

gerbil

nasal, 206

Staphylococcus aureus, ulcerative, 203-204 guinea pig

Trixacarus caviae, hyperkeratotic, 237-238

Staphylococcus aureus, exfoliative, 228-229 hamster

contact, bedding-associated, 196

dermatitis (Continued )

Demodex spp., 191

mouse

acariasis, 86

B6, 96

Corynebacterium bovis, hyperkeratotic, 67-69 favus, 79

pediculosis, 88

Staphylococcus spp., ulcerative, 70-71

Streptococcus spp., 72

rabbit

acariasis, 302-303

exfoliative dermatosis, 309

Fusobacterium necrophorum (necrobacillosis), 278-279 pediculosis, 304

Pseudomonas aeruginosa, 285

Staphylococus aureus, 285-286

rat

acariasis, 154

Cowpox Virus (CPXV), 124

Staphylococcus aureus, 143-144 dermatophytosis (ringworm, Microsporum canis,

Trichophyton mentagrophytes)

guinea pig, 234

hamster, 186

mouse, 78-79

rabbit, 292-293

rat, 146

dermatosis, exfoliative (sebaceous adenitis), rabbit, 309 diabetes mellitus

Chinese hamster, 193

gerbil, obesity, 207

guinea pig, 243

NOD mouse, 4

diarrhea, see enteritis

DIC, see Disseminated Intravascular Coagulation (DIC) Diffuse Large B Cell Lymphoma (DLBCL), mouse, 110 digits

hamster, 174

bedding-associated dermatitis, 196

mouse

cotton nesting material, 97

mousepox, 23

ringtail, 96

rabbit, self-mutilation, 254, 310

rat, Cow Pox Virus (CPXV), 124

Diplococcus, see Streptococcus pneumoniae dirofilariasis, rabbit, 301

disappearing phenotype syndrome, mouse, 55 Disseminated Intravascular Coagulation (DIC)

rabbit

European Brown Hare Syndrome (EBHS) virus, 266 Rabbit Hemorrhagic Disease (RHD) virus,

265-266

Streptococcus spp., 286

Diversity Outbred (DO) mouse, 2

DNA viruses

guinea pig, 218-220

hamster, 175-178

mouse, 14-23

rabbit, 257-264

rat, 121-125

drug-related disorders

gerbil

antibiotic toxicity, 201

streptomycin toxicity, 208

guinea pig, antibiotic toxicity, 224-225

hamster, antibiotic toxicity, 180 mouse

chloroform toxicity, 103

NSAIDS-associated nephropathy, 103 rabbit

antibiotic toxicity, 273, 316

drug toxicosis, 316

fluoroquinolone arthropathy, 316 ionophore toxicity, 316 ketamine-xylazine cardiomyopathy, 316 telazol nephrotoxicity, 316 rat, 162

chloral hydrate ileus, 162

ketamine-xylazine corneal lesions, 162

NSAIDS renal papillary and tubular necrosis, 162 dutch belted rabbit, 253 anterior corneal dystrophy, 318 enterohemorrhagic Escherichia coli, 278 ketamine/xylazine cardiomyopathy, 316 dwarf rabbit, encephalitozoonosis, 295 dysautonomia, rabbit, 273, 276 dysbiosis

guinea pig, 225

hamster, 180, 186

mouse, 52

rabbit, 275, 277, 306, 307, 316

Dysferlin mutation, A and SJL mice, 105 dysgerminoma gerbil, 210 mouse, 115

dystocia, guinea pig, 249

Dystrophin mutation, C57BL/10ScSn mouse, 105

E

ear

gerbil, 200

aural cholesteatoma, 207

guinea pig

chewing, 245

otitis media, 231

hamster, Notoedres spp., 191, 192 mouse

auricular chondritis, 96

cochlear degeneration, 98

coryneform hyperkeratosis, 68 gangrene/notching, 96 rabbit, 254

Cottontail Rabbit Papilloma Virus (CRPV), 260

Pasteurella multocida, 283, 284

Psoroptes cuniculi, 303

Rabbit (and hare) fibroma virus, 264

Sarcoptes scabei, 303, 304

rat

auricular chondropathy, 159-160

Notoedres muris, mange, 154

Zymbal's gland tumor, 164

ear canker (Psoroptes cuniculi), rabbit, 303

EBHS. European Brown Hare Syndrome (EBHS), rabbit, 266

ecotropic viruses, mouse, 26, 40-42, 44, 109 ectoparasites. see helminth infestations; acariasis;

pediculosis; fleas; myiasis

Ectromelia Virus (ECTV), mouse, 21-23

EDIM, Epizootic Diarrhea of Infant Mice (EDIM), mouse, 37-38

EHEC. Enterohemorrhagic E. coli (EHEC), rabbit,

278

Eimeria spp. (intestinal and hepatic coccidiosis) guinea pig

Eimeria caviae, 236

mouse

Eimeria falciformis, 82

Eimeria ferrisi, 82

Eimeria papillata, 82

Eimeria vermiformis, 82

rabbit

Eimeria coecicola, 297

Eimeria exigua, 297

Eimeria flavescens, 297, 298

Eimeria intestinalis, 297, 298

Eimeria irresidua, 297

Eimeria magna, 297, 298

Eimeria media, 297

Eimeria perforans, 297

Eimeria piriformis, 297, 298

Eimeria stiedae, 298-300

Eimeria vejdovskyi, 297

rat

Eimeria spp., 151 embryonal carcinoma, mouse, 115, 116 embryonic/fetal viability, mouse, 5 embryonic stem (ES) cells

mouse, 3

teratoma, 115

empyema

mouse, Klebsiella pneumoniae, 62 rabbit, Pasteurella multocida, 284 encephalitis/encephalomyelitis

guinea pig

equine herpesvirus-1, 220

Lymphocytic Choriomeningitis Virus (LCMV), 220 picornavirus, 221

mouse

Lactate Dehydrogenase-elevating Virus (LDV), 25

Lymphocytic Choriomeningitis Virus (LCMV), 25

Mouse Encephalomyelitis Virus (MEV), 35-36

Mouse Hepatitis Virus (MHV), 29

Murine Adenovirus (MAdV-1), 14-15 reovirus, 36

rabbit

Borna virus, 264

Encephalitozoon cuniculi, 294, 295

rat, Rat Theilovirus (RTV), 128

Encephalitozoon cuniculi

guinea pig, 234

hamster, 186

mouse, 79

rabbit, 293-295

cataracts, uveitis, 318

rat, 146

encephalomalacia

guinea pig, vitamin E deficiency, 241

rabbit, Encephalitozoon cuniculi, 294 Encephalomyocarditis Virus (EMCV), mouse, 35 encephalopathy

hamster

Hamster Parvovirus (HaPV), 176

spontaneous hemorrhagic necrosis, 193 mouse, Reye's-like syndrome, 95 rat, Rat Virus (RV), 123

endocardial spindle cell proliferation, rat, 156 endocrine system

guinea pig, neoplasms, 252

hamster

disorders of, 193

neoplasms, 198

mouse 8-9

disorders, 102

neoplasms, 116-117

endogenous viruses

guinea pig, 221

cavian leukemia, 251

hamster, 179

mouse

lymphoid neoplasia, 109

mammary neoplasia, 111-112

retroelements and retrovirus infections, 38-44 rabbit, 268-269

rat, 129

endometrial hyperplasia, cystic

guinea pig, 249

mouse, 104

rabbit, 310, 320

endometrial venous aneurysms, rabbit, 310, 311 endometritis. see metritis

endoparasites. see protozoa; helminths English spotting locus (En), rabbit, megacolon­syndrome, 319

enrofloxacin arthropathy, rabbit 316 enteritis/enterocolitis/enterotyphlocolitis gerbil

antibiotic-associated, 201

Citrobacter rodentium, 201

Clostridium difficile, 201

Clostridium piliforme (Tyzzer's disease) 202

Cryptosporidium spp., 205

Giardia duodenalis, 205

Salmonella enterica, 203

guinea pig

antibiotic toxicity, 224, 225

Brachyspira spp., 223

Brucella spp., 223

Campylobacter jejuni, 224

cecal volvulus, 247

Citrobacter freundii, 224

Clostridium piliforme (Tyzzer's disease), 225

Clostridium spp., 224

coronavirus-like infection, 220

Cryptosporidium wrairi, 235-236

Eimeria caviae, 236

Escherichia coli, 226

enteritis/enterocolitis/enterotyphlocolitis (Continued )

Histoplasma capsulatum, 235

Lawsonia intracellularis, 226

Salmonella enterica, 228

Yersinia pseudotuberculosis, 230-231 hamster

antibiotic-associated, 180

Campylobacter jejuni, 180

cecal mucosal hyperplasia, 181

Clostridium difficile, 180

Clostridium piliforme (Tyzzer's disease), 181, 182

Cryptosporidium spp., 189

Escherichia coli, 182

Giardia muris, 189

Hamster Parvovirus (HPV), 175

Helicobacter spp., 182-183

Lawsonia intracellularis, 183-184

Rodentolepis nana, 190

Yersinia pseudotuberculosis,186

mouse

Brachyspira sp., 50

Citrobacter rodentium, 50

Clostridium piliforme (Tyzzer's disease), 53

Clostridium spp., 52-53

Cryptosporidium spp., 82

Eimeria spp., 82-83

Epizootic Diarrhea of Infant Mice (EDIM), 37-38

Escherichia coli, 54-55

Helicobacter spp., 55-57

Giardia muris, 83

Lawsonia intracellularis, 58

Mouse Hepatitis Virus (MHV), 27, 30

Murine Adenovirus (MAdV-2), 15 pinworms, 85 reovirus, 36

Salmonella enterica, 58

Spironucleus muris, 83-84

tapeworms, 85

rabbit

adenovirus, 257

astrovirus, 264

Campylobacter spp., 272

Clostridium piliforme (Tyzzer's disease), 275, 276

Clostridium spp., 273-275 coronavirus, 267

Cryptosporidium cuniculus, 297

Eimeria spp., 297-298

Epizootic Rabbit Enteropathy (ERE), 276

Escherichia coli, 277-278

Giardia duodenalis, 300 ionophore toxicity, 316 Klebsiella spp., 279 Lawsonia intracellularis, 279-280 lead toxicosis, 316 leporid herpesvirus 4, 258 mucoid enteropathy, 306 Mycobacterium avium paratuberculosis, 282 parvovirus, 259 rotavirus, 267-268 vesivirus, 266

rat

Campylobacter jejuni, 136

Clostridium difficile, 136

Clostridium piliforme, 137

Cryptosporidium spp., 152

Eimeria spp., 151

Enterococcus spp., 138

Helicobacter spp., 139

Infectious Diarrhea of Infant Rats (IDIR), 129

Lawsonia intracellularis, 139

pinworms, 152

Salmonella enterica, 140 enterococcal (streptococcal) enteropathy, rat, 138-139

Enterococcus spp.

mouse, 71-72

rat, 138-139

Enterocytozoon bieneusi, mouse, 79

Enterocytozoon hellem, mouse, 79

Enterohemorrhagic E. coli (EHEC), rabbit, 278 Enteropathogenic E. coli (EPEC), rabbit, 277-278 enteropathy, mucoid, rabbit, 306-307 enteropathy, enterococcal (streptococcal), rat,

138-139

enteropathy/enterotoxemia, Clostridium spp.

guinea pig, 224-225

hamster, 181

mouse, 52-53

rabbit,, 273-275, 316

environmental disorders

mouse

alopecia of B6 mice, 96

auricular chondritis, 96 corneal opacity, 98 dehydration, 91 ear gangrene and notching, 96 frostbite, 97

hypothermia and hyperthermia, 91-92 mechanical muzzle alopecia, 95 ringtail, 96, 97

sloughing of extremities due to cotton nesting materials, 97

rabbit

hutchburn, 309

trichobezoar, 307

rat, 161

conjunctivitis, keratitis, and other corneal lesions, 161

dehydration, 161

high environmental temperature, 161 light cycle aberrations, 161 phototoxic retinopathy and cataracts, 161 quality of bedding, 162

ringtail, 161

hamster, bedding-associated dermatitis, 196

EPEC, Enteropathogenic E. coli, rabbit, 277-278 eosinophilic granulomatous pneumonia, Brown Norway rat, 160

eosinophils

rabbit, 255

rat

cyclic uterine infiltrates, 120 eosinophilic granulomatous pneumonia, 160

Eperythrozoon coccoides, see Mycoplasma coccoides, mouse epicardial mineralization, mouse, 93 epidermotropic lymphoma

hamster, 198

rat, 167

epididymis

hamster, cysts, 195

mouse, pseudocanalization and megaloaryocytosis,

104

epilepsy

gerbil, 199, 206

mouse, 97

epithelial hyalinosis, mouse, 3, 6, 94-95, 101 Epizootic Diarrhea of Infant Mice (EDIM), rotavirus, 37-38

Epizootic Rabbit Enteropathy (ERE), 273, 276-277 equine herpesvirus-1, guinea pig, 220

ERE. Epizootic Rabbit Enteropathy, 273, 276-277 Erysipelas rhusiopathiae, rat, 141 erythrocyte

gerbil, life span, 199

hamster, 174

mouse, 6

hemotropic mycoplasmas, 63, 65

Minute Virus of Mice (MVM), 18 rabbit, 255

lead toxicosis, 316 erythropoiesis, liver, mouse, 7 Escherichia coli

guinea pig, 226

antibiotic toxicity, 225

bacterial mastitis, 231

and cryptosporidiosis, 235

hamster, 180, 182

and Lawsonia intracellularis, 183 mouse, 54-55

and enterotropic Mouse Hepatitis Virus (MHV), 28 and Epizootic Diarrhea of Infant Mice (EDIM) virus, 38

typhlocolitis, 54-55

rabbit, 277-278

and adenovirus, 257

Attaching and Effacing E. coli (AEEC), 277 Enteropathogenic E. coli (EPEC), 254, 277-278 Enterohemorrhagic (EHEC), 278 and Lawsonia intracellularis, 280

and vesivirus, 266

esophagus, megaesophagus, mouse, 101 estrogen

mouse

fibro-osseous lesion, 105 mammary neoplasia, 111 rat, light cycle aberrations, 161

European Brown Hare Syndrome (EBHS), rabbit, 266 european hamster, Hamster Polyomavirus (HaPyV), 176

exfoliative dermatosis, rabbit, 309

exorbital lacrimal gland

rat

megalokarya/polykarya, 120-121

Sialodacryoadenitis Virus (SDAV), 125 extrachromosomal milk factor, 42 extramedullary hematopoiesis

gerbil, spleen, 208

mouse, 6

liver, 7, 8

spleen, 9, 10

rat, spleen, 119, 157

eye

gerbil, ocular proptosis, 207

guinea pig, 213

mouse

blepharitis and conjunctivitis, 98-99

corneal opacity, 98

Ectromelia Virus (ECTV) conjunctivitis, 21-23

Harderian gland neoplasia, 114 microphthalmia and anophthalmia, 99 retinal degeneration, 99

rabbit

congenital glaucoma (buphthalmia), 318 Encephalitozoon cuniculi, cataracts and uveitis, 295

Herpes simplex virus conjunctivitis, 259

iridial xanthomatosis, 314

myxoma virus conjunctivitis, 261-263

ocular cataracts, 318

Pasteurella multocida, 283-284

prolapse of the deep gland of the third eyelid, 309 retinopathy, bornavirus, 264 rat

conjunctivitis, keratitis, and other corneal lesions, 161-162

megaloglobus, Sialodacryoadenitis Virus (SDAV),

126

phototoxic retinopathy and cataracts, 161 ketamine-xylazine corneal lesions, 162 chromodacryorrhea, 125, 127

F

fancy mouse, 2

fancy rat, 119

fatty liver. see hepatic lipidosis

favus, mouse 79

female

gerbil, 199, 200

cystic ovaries, 208

granulosa cell tumor, 210

hyperadrenocorticism, 207

guinea pig, 213-214

cystitis, 248

mammary neoplasia, 250-251

ovarian cysts, 249

pregnancy toxemia, 243

reproductive tract neoplasia, 251

hamster, 173, 174

amyloidosis, 194

atrial thrombosis, 194

bile ductular hyperplasia, 196

glomerulonephropathy, 196

mouse, 6, 8, 9, 10, 11

adenomyosis, 104

barbering, 90

cystic endometrial hyperplasia, 104

dystrophic mineralization of corneal stroma, 93 endocrine neoplasms, 116-117

female (Continued )

fibro-osseous lesions in aged mice, 105

infertility, 89-90

mammary hyperplasia, 97

microphthalmia and anophthalmia, 99 myoepithelioma, 114-115

reproductive neoplasms, 115

rabbit, 253, 254, 257

cystic mastitis, 313

endometrial venous aneurysm, 310

mammary neoplasms, 322

pregnancy toxemia, 313

pyometra, 284, 285

uterine adenocarcinoma, 320, 321

rat, 119, 120

light cycle aberrations, 161

mammary tumors, 164-166

persistant vaginal septum, 161

pituitary gland adenoma, 168 fetus

guinea pig

Kurloff cell, 215

Listeria monocytogenes (listeriosis), 226

placenta, 217

pubic ligament, 218

pregnancy disorders, 249

vitamin E deficiency, 241

hamster

Hamster Parvovirus (HPV), 175

placenta, 174

spontaneous hemorrhagic necrosis, central nervous system, 193

mouse

cleft lip/palate, 100-101

Ectromelia Virus (ECTV), 22

infertility, 90

Lactate Dehydrogenase-elevating Virus (LDEV), 25

Lymphocytic Choriomeningitis Virus (LCMV), 24

Mouse Cytomegalovirus (MCMV), 16

Mouse Hepatitis Virus (MHV), 27

Mouse Parvovirus (MPV), 18

Pasteurella pneumotropica, 65

Sendai virus, 34

Streptobacillus moniliformis, 67

viability/death, 5

rabbit

Listeria monocytogenes (listeriosis), 281

Encephalitozoon cuniculi, congenital ocular cataracts, 318

vitamin A toxicity or deficiency, 314 rat

Pasteurella pneumotropica, 142

persistent vaginal septum, 161

Rat Virus (RV), 123, 124

Sendai virus, 128

fibroma, uterine, guinea pig, 251

fibromatosis

rabbit (and hare) fibroma viruses, 263-264

rat, endocardial, 156

fibro-osseous lesions, mouse, bone 105 fleas

rabbit

Cediopsylla simplex (common eastern rabbit flea), 304 Ctenocephalides spp. (dog and cat fleas), 304 Odontopsyllus multispinosus (giant rabbit flea), 304 Spilopsyllus cuniculi, 304

rat

Leptopsylla sp., 153

Nosopsyllus sp., 153 Xenopsylla sp., 153 fluoride toxicosis, rabbit, 315 fly strike. see myiasis

Foa-Kurloff cell, guinea pig, 214, 215

follicle mites, see acariasis follicular B cell lymphoma, mouse, 110 foreign body periondontitis (hair tooth), mouse, 70, 100, 101

foreign body pneumonia

guinea pig, 245-246

mouse, aspiration, 100

Francisella tularensis (tularemia)

hamster, 185-186

rabbit, 278

Freund's adjuvant, pulmonary granulomas

guinea pig, 246

mouse, 100

Friend leukemia virus, mouse, 14, 39, 40

frostbite, nude mouse, 97

F344 rat

Large Granular Lymphocytic (LGL) leukemia, 166-167 mesothelioma, 169-170

testicular interstitial cell tumor, 169, 170

fungal infections (mycoses)

guinea pig, 234-235

Cryptococcus neoformans, 235

Encephalitozoon cuniculi, 234 Histoplasma capsulatum, 234-235

Pneumocystis spp., 234

Trichophyton mentagrophytes, 234

hamster, 186

Encephalitozoon cuniculi, 186

Microsporum sp., 186

Trichophyton sp., 186

mouse, 78-81

Aspergillus spp., 79

Candida spp., 79

Crypyococcus neoformans, 79

Encephalitozoon cuniculi, 79 Enterocytozoon bieneusi, 79 Enterocytozoon hellum, 79

Paecilomyces sp., 79

Pneumocystis murina, 79-81

Rhizopus sp., 79

Trichophyton mentagrophytes, 78-79

Trichosporum beigelii, 79

rabbit, 292-296

Aspergillus spp., 292

Emmonsia sp., 296

Encephalitozoon cuniculi, 293-295

Histoplasma sp., 296

Malassezia spp., 295

Microsporum canis, 292-293

Pneumocystis oryctolagi sp. nov., 295-296 Trichophyton mentagrophytes, 292-293

rat, 145-147

Aspergillus spp., 145

Blastomyces dermatidis, 145-146

Encephalitozoon cuniculi, 146

Pneumocystis carinii, 146-147

Pneumocystis wakefieldiae, 146-147

Trichophyton mentagrophytes, 146

fur mites, see acariasis

furunculosis, nude mouse, 70

Fusobacterium necrophorum (necrobacillosis), rabbit, 278-279 fusus coli, rabbit, 254

FVB mouse, 3, 4

albinism, Tyr retroelement mutation, 41

Harderian gland tumors, 114 hepatic tumors, 113 lymphomas, 109

mammary neoplasia, hyperplasia, 102, 111 pheochromocytomas, 117

pituitary gland adenoma, hyperplasia, 102, 116-117 pugilism, 90

pulmonary adenoma, 112, 113 retinal degeneration, 99 seizures, 97

G

gall bladder

mouse, hyalinosis, 94, 95, 101

rabbit, Eimeria stiedae, 299, 300

GALT. see gut associated lymphoid tissue (GALT) gangrene

mouse

barbering, 90

cotton nesting material, 97

ear notching, 96

Ectromelia Virus (ECTV), 22, 23

ringtail, 96

Staphylococcus aureus, ulcerative dermatitis, 71 rat, ringtail, 161

gastric disorders

gerbil

Cryptosporidium spp., 205

Helicobacter pylori, 203, 210

guinea pig

dilatation (bloat) and volvulus, 246

metastatic mineralization, 242

ulcers, 246

hamster

intestinal metaplasia (Giardia muris), 189

ulcers, Escherichia coli, 182

mouse

atrophy, Helicobacter muridarum, 5 7

Candida pintolopessii, 79

Cryptosporidium muris, 82

mucosal hyperplasia, immunodeficient mouse, 101 rabbit

dilation (bloat), 276, 306

Epizootic Rabbit Enteropathy (ERE), bloat, 276

Helicobacter spp., 279

helminth infestation, 302

pyloric muscular hypertrophy, 307

trichobezoar, 307

ulceration, 307

gastrointestinal system

gerbil

Citrobacter rodentium, 201

Clostridium difficile (enterotoxemia), 201

Clostridium piliforme (Tyzzer's disease), 201-202

Helicobacter spp., 203

helminths, 205

Leptospira spp. (leptospirosis), 203

Listeria monocytogenes (listeriosis) 203 malocclusion, 207

periodontal disease and dental caries, 206-207 pinworms, 205 protozoa, 204-205

Salmonella enterica, 203

guinea pig, 216

anorectal impaction, 247

Brachyspira spp. (intestinal spirochetosis), 223

Campylobacter spp. 224

cecal volvulus, 247

chelitis, 246

cholangiofibrosis, idiopathic, 247

Citrobacter freundii, 224

Clostridium piliforme (Tyzzer's disease), 225

Clostridium spp. (enterotoxemia), 224-225 commensal and opportunistic protozoa, 237 coronavirus-like infection, 220

Cryptosporidium wrairi, 235-236

Eimeria caviae, 236

Escherichia coli, 226

Fasciola spp., 237

fatty infiltration of the pancreas, 247

gastric dilatation and volvulus, 246

gastric ulcers, 246

Guinea Pig Cytomegalovirus (GPCMV), 219 helminths, 237

hepatic contusions, 247

hepatic necrosis, focal, 247

Histoplasma capsulatum, 235

intestinal hemosiderosis, 246-247

Lawsonia intracellularis (intestinal adenomatosis), 226

Listeria monocytogenes (listeriosis), 226-227 malocclusion, “slobbers,” 246

odontoma, 251

rectal prolapse, 247

Yersinia pseudotuberculosis (pseudotuberculosis), 230-231 hamster, 174

adenovirus, 175

bile ductular hyperplasia: hepatic cirrhosis, 196 Campylobacter jejuni, 180 cecal mucosal hyperplasia, 181

Clostridium difficile (enterotoxemia), 180-181

Clostridium piliforme (Tyzzer's disease), 181-182 Cryptosporidium spp., 189 enteric bacterial infections, 180-185

Escherichia coli, 182

Giardia muris (chronic giardiasis), 189

Hamster Parvovirus (HPV), 175

Helicobacter spp., 182-183

helminths, 190-191

Lawsonia intracellularis (Transmissible Ileal Hyperplasia), 183-184, 185 malocclusion, 196

gastrointestinal system (Continued )

mucosal hyperplasia, 181 periodontal disease, 196 pinworms, 190 polycystic disease/polycystic liver disease, 195-196 protozoa, 188-190

Salmonella enterica, 184-185

Spironucleus muris, 189-190 tapeworms, 190-191

mouse, 6-7

Aerococcus viridans, 67, 68 bacterial enteric infections, 50-60 candidiasis, 79

Citrobacter rodentium (Transmissible Murine Colonic Hyperplasia), 50-52

cleft lip/palate, 100

Clostridium piliforme, 53-54

Clostridium spp. enteropathy, 52-53 colitis cystica, 50, 51, 108

Cryptosporidium muris, C. parvum, C. tyzzeri, 82 disorders of, 100

Eimeria spp. (coccidiosis), 82-83

Epizootic Diarrhea of Infant Mice (EDIM) virus, 37-38

Escherichia coli, 54-55

gastric mucosal hyperplasia, 101

Giardia muris, 83

Helicobacter spp., 55-58

helminths, 84-86 hepatocellular neoplasia, 113-114 intestinal amyloidosis, 92, 93 Lawsonia intracellularis, 58 liver disorders, 101 malocclusion, 100 megaesophagus, 101

Mouse Hepatitis Virus (MHV), 27-31

Murine Adenovirus (MAdV-2), 14-15 periondontitis, foreign body (hair tooth), 100 pinworms, 84-85 protozoa, 82-84

Salmonella enterica, 58-59 segmented filamentous bacteria, 59-60 Spironucleus muris (spironucleosis), 83-84 tapeworms, 85-86

rabbit, 255, 256

Actinomyces spp. (granulomatous osteitis), 271 adenovirus, 257 aflatoxicosis, 316 anorectal polyps, 308 antibiotic toxicity, 316

astrovirus, 264

bile duct adenomas and adenocarcinomas, 322 biliary hyperplasia, 308

Campylobacter spp., 272

Capillaria hepatica, 301

Clostridium piliforme (Tyzzer's disease) 275-276

Clostridium spp. enteropathy/enterotoxemia, 273-275 copper toxicosis, 315

Cryptosporidium cuniculus, 297

Eimeria spp., 297-300

enteric coronavirus, 267

Epizootic Rabbit Enteropathy (ERE), 276-277 Escherichia coli, 277-278

gastric dilation (Bloat), 306

gastric pyloric hypertrophy, 307

gastric ulceration, 307

Giardia duodenalis, 300

Helicobacter spp., 279

helminth infestations, 301, 302

hepatic lobe torsion, 308

intestinal obstruction and rupture, 307

intestinal plasmacytosis, 308

Klebsiella spp., 279

lapine parvovirus, 259

Lawsonia intracellularis (histiocytic enteritis), 279-280

Listeria monocytogenes (listeriosis), 280-281 malocclusion, 318-319

megacolon-syndrome of spotted rabbits, 319 mucoid enteropathy, 306, 307

Mycobacterium avium paratuberculosis (paratuberculosis), 282

odontoma, 322

pinworms, Passalurus ambiguus, 301

protozoa, nonpathogenic, 300

Rabbit Oral Papilloma Virus (ROPV), 260-261 rotavirus, 267-268

stasis, 306

tapeworms, 302

tooth abscesses, 309

trichobezoar, 307

tympany, 307

wet dewlap, 308

Yersinia pseudotuberculosis (pseudotuberculois), 288 rat

adenovirus, 121-122

aging lesions of the liver, 156-157

Campylobacter jejuni, 136

Clostridium difficile, 136-137

Clostridium piliforme (Tyzzer's disease), 137-138

Cryptosporidium spp., 152

enteric bacterial infections, 136-141

enterococcal enteropathy, 138-139

Helicobacter spp., 139

helminths, 153

Infectious Diarrhea of Infant Rats (IDIR), 129

Lawsonia intracellularis, 139-140

pancreatic islet hypertrophy and fibrosis, 157 pinworms, 152

protozoa, 151-152

Salmonella enterica, 140

genital system, see Reproductive system; Urinary System

Genetically Engineered Mouse (GEM), 1

neoplasia, 108-109 genetics and genomics, mouse, 2

pathology considerations, 4-5

genetic disorders

gerbil

epilepsy, 206

neoplasia, 209-210

guinea pig

endogenized viruses, 221

malocclusion, 246

neoplasia, 250-252

hamster

diabetes mellitus, 193

hydrocephalus, 197

neoplasia, 197-198

mouse

cleft lip/palate, 100-101 mucometra/hydrometra, 103-104 muscular dystrophy, 105 neoplasia, 108-117

retroelements and retrovirus infections, 38-44 rabbit, 253, 318-319

anterior corneal dystrophy, 318

congenital glaucoma (buphthalmia), 318 endogenized viruses, 268 malocclusion, 318-319

megacolon-syndrome of spotted rabbits, 319 neoplasia, 320-322

ocular cataracts, 318

polycystic kidney disease, 319

splay leg, 319

rat

endogenous viral integrations, 129

malocclusion, 160

neoplasia, 164-170

peripheral retinal degeneration, 161 genitourinary system, see urogenital system

Gerbil, 199

Anatomic features, 199-200

Anatomy, 200

Hematology, 199

Bacterial infections, 201-204

Bordetella bronchiseptica infection, 201

Cilia-Associated Respiratory (CAR) bacillus infection, 201

Citrobacter rodentium infection, 201

Clostridium difficile entercolitis: Antibiotic toxicity, 201

Clostridium piliforme infection: Tyzzer's disease, 201

Helicobacter spp. infection, 203

Leptospira spp. infection: leptospirosis, 203 Listeria monocytogenes infection: listeriosis, 203 Salmonella enterica infection: salmonellosis, 203 Staphylococcus aureus infection: staphylococcal dermatitis, 203

Genetic, metabolic, and other disorders, 206-208

Amyloidosis, 208

Aural cholesteatoma, 207

Barbering, 206

Chronic glomerulonephropathy, 208

Cystic ovaries, 208

Epilepsy, 206

Focal myocardial degeneration, 207

Hyperadrenocorticism/cardivascular disease of breeding gerbils, 207

Malocclusion, 207

Nasal derrmatitis, 206

Obesity and diabetes, 207

Ocular proptosis, 207

Periodontal disease and dental caries, 206

Spongiosis, of the caudate nucleus, 207

Tail slip, 206

Introduction, 199

Neoplasms, 209-210

Parasitic diseases, 204-205

Arthropod Infestations, 205

Mite infestations: acariasis, 205

Helminth infestations, 205

Protozoal infections, 204-205

Toxic disorders, 208-209

Lead toxicity, 209

Streptomycin toxicity, 208

Viral infections, 200-201

germline insertional mutagenesis, 41

Giardia spp. (giardiasis)

gerbil, 205

guinea pig, 237

hamster, 189

mouse, 83

rabbit, 300

rat, 151

glaucoma (buphthalmia), rabbit, congenital, 318 glomeruli, ectopic, rabbit, 256 glomerulonephritis, mouse, 102 glomerulonephropathy

gerbil, 208

hamster, 196

mouse, 102 glomerulosclerosis, rat, 157-158 goblet cell “hyperplasia”, rabbit, 306 golden hamster (Mesocricetus auratus) 173 Graft versus Host Disease (GVHD), 4, 95 granulocytes

mouse, 6

rat, 119 granulomatous inflammation

guinea pig

Cryptococcus neoformans, 234-235 foreign body pneumonia, 245-246 Freund's adjuvant, pulmonary, 246 nematode larval migrans, 237 Salmonella spp., 228

hamster

bedding-associated dermatitis, 196

Clostridium piliforme (Tyzzer's disease), myocarditis, 182

Lawsonia intracellularis, proliferative ileitis, 184 Mycobacterium sp. 186

mouse

auricular chondritis, 96

Encephalitozoon cuniculi, 79

Freund's adjuvant, pulmonary, 100

Mouse Hepatitis Virus (MHV), serositis, 30

Salmonella enterica, hepatitis, 58 systemic and pulmonary mycoses, 79 rabbit

Actinomyces spp., bone, 271

Aspergillus spp., pulmonary, 292

Baylisascaris spp. (larval migrans), 300-301

Capillaria hepatica, liver, 301

Encephalitozoon cuniculi, 294-295

Franciella tularensis (tularemia), 278

Mycobacterium avium paratuberculosis (paratuberculosis), 282

Mycobacterium bovis, M. tuberculosis (tuberculosis), 282 tapeworms, 302

granulomatous inflammation (Continued )

Toxoplasma gondii (toxoplasmosis), 300

Yersinia pseudotuberculosis (pseudotuberculosis), 288

rat

auricular chondritis, 159-160

eosinophilic granulomatous pneumonia, brown norway rat, 160

granulosa cell tumor

gerbil, 210

guinea pig, 251

mouse, 115

grass sickness (dysautonomia), rabbit, 273, 276 gray hamster. see Chinese hamster green fur syndrome, rabbit, 285

Guarnieri bodies (Cow Pox Virus), rat, 124

Guinea Pig, 213

Bacterial infections, 222-231

Bordetella bronchiseptica infection, 222

Brachyspira spp. infection: intestinal spirochetosis, 223

Brucella spp. infection: brucellosis, 223 Campylobacter spp. infection,224

Chlamydophila caviae infection: guineapig inclusion body conjunctivitis, 224

Citrobacter fruendii infection, 224

Clostridium difficile and Clostridium perfringens enterotoxemia: “antibiotic toxicity”, 224

Clostridium piliforme infection:Tyzzer's disease,

225

Corynebacterium spp infection, 225 Escherichia coli infection: colibacillosis, 226 Klebsiella pneumoniae infection, 226 Lawsonia intracellularis infection: adenomatous intestinal hyperplasia, 226

Leptospira spp. infection: Leptospirosis, 226 Listeria monocytogenes infection: Listeriosis,

226

Miscellaneous bacterial syndromes, 231

Bacterial conjunctivitis, 231

Bacterial Mastitis, 231

Otitis Media, 231

Mycobacterium spp. infection: tuberculosis, 227 Mycoplasma spp. and Acholeplasma spp. infections, 227

Pasteurella multocida infection: pasteurellosis, 228 Pseudomonas and Aeromonas infection, 228 Salmonella spp. infection: salmonellosis, 228 Staphylococcus aureus infections:

Staphylococcosis, 228-229

Pododermatitis, 228

Staphylococcal dermatitis: exfoliative dermatitis, 228

Streptobacillus moniliformis infection, 229 Streptococcal infections, 229-230

Streptococcus equi subsp. Zooepidemicus infections: cervical lymphadenitis, septicemia, 229

Streptococcus pneumoniae infection: diplococcal or pneumococcal infection, 230

Streptococcus spp. infections: hemorrhagic septicemia, 230

Yersinia pseudotuberculosis infection: pseudotuberculosis, yersiniosis, 230 Behavioral, physiologic, and anatomic features, 213-217

Anatomic features, 214-217

External features, 214

Gastrointestinal system, 216

Lymphoid and hematopoetic systems, 214

Musculoskeletal system, 217

Reproductive system, 216

Respiratory system, 215

Urinary system, 216

Behavioral features, 213-214

Unique physiological features, 214

Fungal infections, 234-235

Cryptococcus neoformans infection: cryptococcosis, 234

Dermatophyte infection: dermatophytosis, 234 Encephalitozoon cuniculi infection:

microsporidiosis, 234

Histoplasma capsulatum infection: histoplasmosis, 235

Pneumocystis spp. infection: Pneumocystosis, 234 Gastrointestinal diseases, 246-247

Anorectal impaction, 247

Cecal volvulus, 247

Cheilitis, 246

Chronic idiopathic cholangiofibrosis, 247

Fatty infiltration of the pancreas, 247

Focal hepatic necrosis, 247

Gastric dilatation and volvulus, 246

Gastric ulcers, 246

Hepatic contusions, 247

Intestinal hemosiderosis, 246

Malocclusion: “slobbers”, 246

Prolapsed rectum, 247

Introduction, 213

Miscellaneous disorders, 245-246

Adjuvant associated pulmonary granulomas, 246

Alopecia, 245

Behavioral diseases, 245

Foreign body pneumonia: Pneumoconiosis, 245

Osteoarthritis, 246

Neoplasms, 250-252

Cavian leukemia, 251

Cutaneous neoplasia, 250

Endocrine and cardiovascular neoplasia, 252 Mammary neoplasia, 250

Other neoplasms, 252

Pseudo-odontoma: Odontoma, 251

Reproductive tract neoplasia, 251

Respiratory tract neoplasia, 251

Nutritional, metabolic, and toxic disorders, 239-244

Diabetes mellitus, 243

Hypovitaminosis C: scurvy, 239

Metastatic mineralization, 242

Myopathies, 241-242

Cardiac Glycogenosis:Rhabdomyomatosis, 241

Myocardial and skeletal muscle degeneration with mineralization, 241

Nutritional myopathy, 241

Pregnancy toxemia, 243

Circulatory/toxic form: Preeclampsia, 243

Metabolic form, 243

Systemic amyloidosis, 243

Toxic disorders, 244

Parasitic diseases, 235-238

Arthropod infestations, 237-238

Chirodiscoides caviae infestation: fur mites, 237

Demodex caviae infestation, 238

Other mite infestations, 238

Pediculosis, 238

Trixacarus caviae infestation: mange mites, 237

Helminth infestations, 237

Fasciola spp. infestation, 237

Miscellaneous other helminth infections, 237

Nematode larval migrans, 237

Paraspidodera uncinata, 237

Peloderma strongyloides, 237

Protozoal infections, 235-237

Cryptosporidium wrairi infection: cryptosporidiosis, 235

Eimeria caviae infection: intestinal coccidiosis, 236

Klossiella cobayae infection: renal coccidiosis, 236

Miscellaneous commensal and opportunistic Protozoa, 237

Toxoplasma gondii infection: toxoplasmosis, 236

Urogenital diseases, 247-249

Cystitis and Urolithiasis, 248

Disorders of pregnancy, 249

Male genitourinary diseases, 249

Nephrosclerosis: chronic renal disease, 247

Ovarian cysts, 249

Viral infections, 218-221

DNA viral infections, 218-220

Equine herpesvirus 1 infection, 220

Guinea pig adenovirus infection, 218

Guinea pig cytomegalovirus infection, 219

Other guinea pig herpes viral infections, 219

Poxvirus infection, 220

Endogenized viruses, 221

RNA viral infections, 220-221

Arenavirus infection: Lymphocytic Choriomeningitis Virus infection, 220

Coronavirus-like infection, 220

Influenza virus infection, 220

Other viral infections, 221

Parainfluenza virus infections, 220

Picornavirus infection, 221

Rabies virus infection, 221

gut associated lymphoid tissue (GALT)

Hamster Polyomavirus (HaPyV) lymphoma, 177 rabbit, 255

histiocyte refractive material, 256 lymphosarcoma, 321

Mycobacterium avium paratuberculosis (paratuberculosis), 282

H

H-1 virus, parvovirus

hamster, 175-176

rat, 122-124

H-2 complex, mouse, 11, 13

Haemophilus influenzaemurium, mouse, 65

Haemophilus spp., rat, 141-142

hairball (trichobezoar), rabbit, 307

hair chewing, see barbering

hair growth pattern

mouse, 5

rabbit, 254

hair loss. see alopecia

hair plucking/pulling. see barbering

Hamster, 173

Anatomic features, 173-174

Introduction, 173

Bacterial and fungal infections, 180-186

Bacterial Enteric Infections, 180-185

Campylobacter jejuni infection, 180

Cecal mucosal hyperplasia of unknown etiology, 181

Clostridium difficile enterotoxemia, 180

Clostridium piliforme infection: tyzzer's disease, 181 Escherichia coli infection, 182

Helicobacter spp. infection, 182

Lawsonia intracellularis infection: proliferative ileitis, transmissible ileal hyperplasia, 183

Salmonella enterica infection, 184

Fungal infections, 186

Dermatomycosis, 186

Encephalitozoon cuniculi, 186

Other bacterial infections, 185-186 Corynebacterium spp. infections, 185 Franciella tularensis infection: tularemia, 185 Leptospira ballum infection: leptospirosis, 186 Miscellaneous bacterial infections, 186 Mycobacterium spp. infection, 186 Pasteurella pneumotropica infection, 186 Yersinia pseudotuberculosis infection, 186

Diseases associated with aging, 194-196

Amyloidosis, 194

Atrial thrombosis, 194

Bile ductular hyperplasia: hepatic cirrhosis, 196

Glomerulonephropathy, 196

Other changes associated with aging, 196

Polycystic disease: olycystic liver disease, 195 Environmental, genetic and other disorders, 196-197

Bedding-associated dermatitis, 196

Congenital/hereditary hydrcephalus, 197 Malocclusion, 196

Periodontal disease, 196

Neoplasms, 197-198

Nutritional and metabolic disorders, 193-194

Diabetes mellitus, 193

Hyperadrenocorticism: Cushing's-like syndrome, 193

Pregnancy toxemia: Eclampsia, 193

Spontaneous hemorrhagic necrosis of the central nervous system of fetal hamsters, 193

Parasitic diseases, 188-192

Ectoparasitic infestations, 191-192

Demodex spp. infestation, 191

Notoedres spp. infection, 191 Miscellaneous mite infestations, 191 Myiasis, 192

Helminth infestations, 190-191

Pinworm infestations, 190

Tapeworm infestations, 190 Trichosomoides nasalis infestation, 190

Hamster (Continued )

Protozoal infections, 188-190 Cryptosporidium spp. infections, 189 Giardia muris infection, 189 Other enteric protozoa, 190 Spironucleus muris infection, 189

Viral infections, 175-179

DNA viral infections, 175-178

Adenovirus infection, 175 Cytomegalovirus infection:cricetid herpesvirus,

CrHV-1, 175

Hamster polyoma virus infection: transmissible lymphoma, 176

Papillomavirus infections, 175

Parvovirus infection, 175

Other virus infections of minimal significance, 179

RNA viral infections, 178-179

Lymphoctic Choriomeningitis Virus infection, 178 Pneumonia virus of mice (PVM) infection, 178 Sendai virus infection, 178

hamster female protein, 194

Hamster Parvovirus (HaPV), 175-176

Hamster Polyoma Virus (HaPyV), 176-178 hamster species

Cricetulus griseus (Chinese or gray hamster), 173

Cricetus cricetus (European or black-bellied hamster), 173

Cricetulus migratorius (Armenian or migratory hamster), 173

Mesocricetus auratus (Syrian or golden hamster), 173

Mystromy albicaudatus (South African hamster, white tailed rat), 173

Phodopus sungorus (dwarf, Siberian, Dzungarian hamster), 173

hantavirus, rat, 127

Hantavirus Pulmonary Syndrome (HPS), rat, 127 haplotypes, mouse, 11

Harderian gland

mouse, neoplasia, 114

rat, Sialodacryoadenitis Virus (SDAV), 125-127 hare fibroma virus, rabbit, 264 Harvey sarcoma virus, rat 129

Hassall's corpuscle, thymus, guinea pig, 215

Haverhill fever, rat, 144

Haversian bone, lack of, rodents, 120 hearing loss, mouse, 3, 98 heart

gerbil

focal myocardial degeneration, 207

Tyzzer's disease, 202, 203

guinea pig

cardiac glycogenosis (rhabdomyomatosis), 241-242 myocardial degeneration, 241

neoplasia, 252 hamster, atrial thrombosis, 194-195 mouse

atrial thrombosis, 99, 100

cardiac calcinosis, 93-94

rabbit, 255

coronaviral cardiomyopathy, 267

infarction, hypercholesterolemia, 314 ketamine/xylazine associated cardiomyopathy, 316 Tyzzer's disease, 275, 276

rat

cardiac valvular angiectasis, 156 endocardial spindle cell proliferation, 156 myocardial degeneration/fibrosis, 155 pseudomoniasis, 143

Tyzzer's disease, 137, 138 heart, atrioventricular bicuspid valve, rabbit, 255 heart failure, congestive

hamster, 194

mouse, 3, 99

Helicobacter, colitis hamster, 182-183 mouse, 55, 56, 57 rat, 139

Helicobacter, gastric carcinoma, gerbil, 203 Helicobacter, hepatitis, hepatic neoplasia hamster, hepatic cirrhosis, 196 mouse, 55-58, 101, 113

Helicobacter spp.

gerbil, 201, 203

Helicobacter bilis, 203

Helicobacter hepaticus, 203

Helicobacter pylori, 203

Helicobacter rodentium, 203

hamster, 182-183

Helicobacter aurati, 182

Helicobacter bilis, 182, 183

Helicobacter cholecystus, 182

Helicobacter cinaedi, 182

Helicobacter mesocricetorum, 182 mouse, 55-58

Helicobacter bilis, 55, 56, 57

Helicobacterganmani, 55

Helicobacter hepaticus, 55, 56, 57

Helicobacter magdeburgensis, 55

Helicobacter mastomyrinus, 55

Helicobacter muridarum, 55, 57

Helicobacter pullorum, 55

Helicobacter rappini, 55

Helicobacter rodentium, 55, 56

Helicobacter typhlonius, 55 rabbit, 279

Helicobacter canadensis, 279

Helicobacter felis, 279

Helicobacter heilmanni, 279

Helicobacter pullorum, 279

Helicobacter salomonis, 279

rat, 139

Helicobacter bilis, 139

Helicobacter muridarum, 139

Helicobacter pullorum, 139

Helicobacter trogontum, 139 helminth infestations, hepatic guinea pig, Fasciola spp., 237 rabbit, Capillaria hepatica, 301 rat, Capillaria hepatica, 153 helminth infestations, larval migrans

guinea pig, 237

Baylisascaris spp., 237

Paralaphosostrongylus tenuis, 237

rabbit, 300-301

Baylisascaris spp., 300-301

Toxocara canis, 301 helminth infestations, pinworms gerbil, 205

Aspiculuris tetraptera, 205

Dentostomella translucida, 205

Syphacia obvelata, 205

Syphacia muris, 205

hamster, 190

Aspiculuris tetraptera, 190

Dentostomella translucida, 190

Syphacia criceti, 190

Syphacia mesocriceti, 190

Syphacia obvelata, 190

Syphacia muris, 190

Syphacia peromysci, 190

Syphacia stroma, 190

mouse, 84-85

Aspiculuris tetraptera, 84-85

Syphacia muris, 84-85

Syphacia obvelata, 84-85

rabbit, Passalurus ambiguus, 301

rat, 152

Aspiculuris tetraptera, 152

Syphacia muris, 152

Syphacia obvelata, 152 helminth infestations, other than pinworms and tapeworms guinea pig, 237

Paraspidodera uncinata, 237

Peloderma strongyloides, 237 hamster, Trichosomoides nasalis, 190 rabbit, 301-302

Dirofilaria spp., 301

Graphidium strigosum, 302

Nomatodirus leporis, 302

Obelescoides cuniculi, 302

Trichostrongylus calcaratus, 302

Trichuris leporis, 302

Trichuris sylvilagus, 302

rat, 152-153

Gonglyonema neoplasticum, 153

Heterakis spumosa, 153

Nippostrongylus brazielensis, 153

Trichosomoides crassicauda (bladder threadworm), 152-153

Trichuris muris, 153 helminth infestations, tapeworms adult tapeworms

gerbil, 205

Hymenolepis diminuta, 205

Rodentolepis nana, 205

mouse, 85-86

Hymenolepis diminuta, 85-86

Rodentolepis microstoma, 85-86

Rodentolepis nana, 85-86

rabbit, Cittotaenia variabilis, 302

rat, 153

Hymenolepis diminuta, 153

Rodentolepis microstoma, 153

Rodentolepis nana, 153

cyst (immature) tapeworms

mouse, Cysticercus fasciolaris (Taenia taeniaformis), 85

rabbit, 302

Coenurus serialis (Taenia serialis), 302

Cysticercus pisiformis (Taenia pisiformis), 302

rat, Cysticercus fasciolaris (Taenia taeniaformis), 153 hemangioma/hemangiosarcoma, mouse, 114, 115 hematology

gerbil, 199

mouse, 5-6

rabbit, 255

rat, 119

hematopoiesis

gerbil, extramedullary, 208

guinea pig, 214-215

mouse, 6

extramedullary, 6, 7, 8, 9

rat, 120

extramedullary, 119, 157 hematopoietic neoplasia, mouse, 109-111 hematopoietic system. see lymphoid and hematopoietic systems

hematuria

rabbit, 256, 311, 316

rat, 159

Hemobartonella muris (Mycoplasma haemomuris) mouse, 63, 65

rat, 142

hemochorial placentation

gerbil, 200

guinea pig, 217

mouse, 8

rabbit, 256

hemorrhage, perirenal (Leptospira spp.), guinea pig, 227 hemorrhage, serosal (Rat Virus), rat, 123 hemorrhagic encephalomyelitis, mouse, 14 Hemorrhagic Fever and Renal Syndrome (HFRS), rat, 127 hemorrhagic encephalopathy (Rat Virus), rat, 123 hemorrhagic necrosis of the CNS of fetal hamsters, 193 hemorrhagic septicemia, guinea pig

Leptospira spp., 226

Streptococcus spp., 230

hemosiderin pigment

guinea pig

intestinal, 246-247

scurvy, 240

mouse, splenic, 9, 10

rabbit, splenic, 312

rat, splenic, 119

hemotropic Mycoplasma

mouse

Mycoplasma coccoides, 65

Mycoplasma haemomuris, 65

rat, Mycoplasma haemomuris, 142

hemorrhagic enterotyphlocolitis, Klebsiella spp., rabbit, 279

hepatic coccidiosis, rabbit, 298-300

hepatic contusions, guinea pig, 247

hepatic lipidosis

gerbil, hyperadrenocortism, 207

guinea pig, pregnancy toxemia (metabolic), 243 mouse

BALB strains, 3, 8, 101

Reye's-like syndrome, 95

hepatic lipidosis (Continued )

rabbit

hypercholesterolemia, 314

pregnancy toxemia, 313

trichobezoar, 307

hepatic lobe torsion, rabbit, 308

hepatic necrosis, focal

guinea pig, 247

mouse, 82

hepatic neoplasia

mouse, 108, 113-114

Helicobacter spp. associated, 55, 56, 57

rabbit, bile duct tumors, 322

hepatic peliosis, rat, 156

hepatic sinusoidal dilatation, rat, 156

hepatitis

gerbil, Clostridium piliforme, 201-202

guinea pig

Clostridium piliforme, 225

Listeria monocytogenes, 227

Salmonella spp., 228

Yersinia pseudotuberculosis, 231

hamster

Helicobacter spp., 182-183

Salmonella enterica, 185

mouse

Aerococcus viridans, 67

Clostridium piliforme (Tyzzer's disease), 54

Corynebacterium kutscheri, 69

Ectromelia Virus (ECTV), 22, 23

Encephalitozoon cuniculi, 79

Helicobacter spp., 55-58

Lymphocytic Choriomeningitis Virus (LCMV), 23

Mouse Cytomegalovirus (MCMV), 16

Mouse Hepatitis Virus (MHV), 27-30

Mouse Norovirus (MNV), 31

Mycobacterium avium-intracellare, 72

reovirus, 36

Salmonella enterica, 59

Streptobacillus moniliformis, 67

rabbit

Capillaria hepatica, 301

Clostridium piliforme (Tyzzer's disease), 275

Eimeria steidae, 298-300

Encephalitozoon cuniculi, 294

Hepatitis E Virus (HEV), 267

Listeria monocytogenes, 281

Rabbit Hemorrhagic Disease (RHD) virus, 264

Salmonella enterica, 285

Staphylococcus aureus, 286

Yersinia pseudotuberculosis (pseudotuberculosis), 288 rat, 120

Clostridium piliforme (Tyzzer's disease), 137-138 Corynebacterium kutscheri, 140-141

Hepatitis E Virus (HEV), 129-130

Rat Virus (RV), 123

Hepatitis E virus (HEV)

rabbit, 267

rat, 129-130

hepatocellular changes

hamster

aging-related lesions, 174

mouse

aging-related lesions, 7, 8, 101

rabbit

aging-related changes, 256

copper toxicosis, 315

rat

aging-related changes, 156-157

atrophy, 120

foci of cytoplasmic alteration, 120, 156-157

Hepatozoon cuniculi, rabbit, 300

hermaphroditism, mouse, 5

hernia, lateral femoral triangle, mouse, 106 herpesvirus

guinea pig, 219-220

equine herpes virus 1, 220

Guinea Pig Cytomegalovirus (GPCMV), 219

Guinea Pig Herpes-Like Virus (GPHLV)/Cavid herpesvirus-1, 219

Guinea Pig X Virus (GPXV), Guinea pig herpesvirus-3, 219

hamster, cytomegalovirus (Cricetid herpesvirus, CrHV-1), 175

mouse, 15-17

Mouse Cytomegalovirus (MCMV), 15-17

Mouse Thymic Virus (MTV), 17

rabbit, 258-259

Herpes simplex virus (human herpesvirus-1), 259 leporid herpesvirus 1 (cottontail herpesvirus), 258 leporid herpesvirus 2, 258

leporid herpesvirus 3 (Herpesvirus sylvilagus), 258 leporid herpesvirus 4 (Herpesvirus cuniculi, virus III), 258-259

rat, Rat Cytomegalovirus (RCMV), 122

herpes virus, disseminated, leporid herpesvirus 4, rabbit, 258-259

herpes virus, encephalitis, Herpes simplex virus, rabbit, 259 heterophil (pseudoeosinophil)

guinea pig, 214

hamster, 174

rabbit, 255

HEV, see Hepatitis E Virus (HEV)

HFRS, see Hemorrhagic Fever and Renal Syndrome (HFRS)

hibernation, hamster, 173, 174

hippocampal neurodegeneration, post-ictal, mouse, 97 histiocyte-associated diffuse large B-cell lymphoma, mouse, 110

histiocytic enteritis, (Lawsonia intracellularis), rabbit, 279-280

histiocytic inflammation, see granulomatous inflammation histiocytic sarcoma

hamster

Helicobacter spp. associated, 183

mouse, 110-111

renal tubular hyaline bodies associated with, 103

rat, 167-168

Histoplasma capsulatum, guinea pig, 235

HPS, see Hantavirus Pulmonary Syndrome (HPS)

hutch burn, rabbit, 309

hyalinosis

mouse

epithelial, 6, 94-95

glomerular, 102

hydrocephalus hamster, 197 mouse, 3, 98 rat, 160, 161 hydrometra/mucometra mouse, 103-104 rabbit, 310, 311 hydronephrosis mouse, 102-103

Murine Urologic Syndrome (MUS), 104 rabbit, 311 rat, 159

Hymenolepsis spp., see helminth infestations, tapeworms hyperadrenocorticism

breeding gerbils, 207-208 hamster, 193 hypercalcemia

rabbit

arteriosclerosis, 313

renal disease, 254 thymoma, 322 rat, interstitial cell tumor, 169 hypercholesterolemia rabbit, 254, 314, 315 rat, chronic progressive nephropathy, 157 hyperkeratosis, coryneforme, mouse, 67-69 hyperlipidemia, rabbit, 314 hyperparathyroidism, nutritional secondary, rabbit, 254, 314 hyperpigmented urine, rabbit, 256

Hyperplastic Alveolar Nodules (HANs), mouse, 112 hyperplastic colitis, see colitis, hyperplastic hyperthermia, mouse, 91-92 hypervitaminosis A, rabbit, 314 hypervitaminosis D, rabbit, 315 hyphema, rat, 126 hypocalcemic tetany in lactating does, rabbit, 313 hypocallosity, mouse, 3, 97-98 hypokalemia, rabbit, 298 hypothermia, mouse, 91-92 hypovitaminosis A, rabbit, 314 hypovitaminosis C (scurvy), guinea pig, 239-241 hypovitaminosis D, rabbit, 315 hypovitaminosis E, rabbit, 315

I

icterus (Rat Virus), rat, 123 IDIR, Infectious Diarrhea of Infant Rats, 129 ileal hyperplasia, hamster, 183-184 ileum/ileitis

gerbil, Clostridium piliforme (Tyzzer's disease), 202 guinea pig

Clostridium piliforme (Tyzzer's disease), 225 coronavirus-like infection, 220 Cryptosporidium spp., 235-236

Yersinia pseudotuberculosis (pseudotuberculosis), 231 hamster

adenovirus, 175

Clostridium difficile (enterotoxemia),181 Clostridium piliforme (Tyzzer's disease), 182 Escherichia coli, 182

Lawsonia intracellularis (Transmissible Ileal Hyperplasia), 183-184

mouse

amyloidosis, 93

Paneth cells, 7

segmented filamentous bacteria, 59-60 rabbit

Clostridumpiliforme, 275, 276

Clostridium spp. enteropathy/enterotoxemia, 274

Eimeria spp. (intestinal coccidiosis), 298

Lawsonia intracellularis (histiocytic enteritis), 279 obstruction, 308 rotavirus, 268

segmented filamentous bacteria, 254

rat

Clostridiumpiliforme (Tyzzer's disease), 137

Salmonella enterica, 140

ileus

rat, chloral hydrate, 162 lactating mice, 53

immune system

guinea pig, 214-215

mouse, 9, 10-11

genetically engineered immunologic mutations, 11 immunoglobulins, 10

immunologic idiosyncracies, 10-11

rabbit, 255, 256

rat, 119

inbred strains, mouse, 3-4 incisors

gerbil, 200

malocclusion, 207

guinea pig, 216

malocclusion, 246

odontoma, 251

hamster, 174

malocclusion, 196

Hamster Parvovirus (HaPV), 175, 176 mouse, 6

malocclusion, 100

rabbit, 256

rat, malocclusion, 160

malocclusion (maxillary brachygnathia), 318-319 odontoma, 322-323

vitamin D deficiency, 315

inclusion body conjunctivitis, guinea pig, 224 inclusion body nephritis, mouse, 103 inclusion bodies, viral

intracytoplasmic

Cow Pox Virus (CPXV), rat, 124, 125

Cricetid herpesvirus (CrHV-1), 175 cricetid herpesvirus, hamster, 175 Ectromelia Virus (ECTV), mouse, 22, 23

Epizootic Diarrhea of Infant Mice (EDIM), mouse, 38

Guinea Pig Cytomegalovirus (GPCMV), 219 hare fibroma virus, rabbit, 264

Infectious Diarrhea of Infant Rats (IDIR), rat, 129 leporid herpesvirus 4, rabbit, 258

Mouse Cytomegalovirus (MCMV), 15, 16

Mouse Hepatitis Virus (MHV), 29 myxoma virus, rabbit, 262, 263 rabbit fibroma virus, 263, 264 Rat Cytomegalovirus (RCMV), 122 Sendai virus

inclusion bodies, viral (Continued ) mouse, 34 rabbit, 267

intranuclear

adenovirus

guinea pig, 218 hamster, 175 mouse, 14, 15 rat, 121

Cricetid herpesvirus (CrHV-1) hamster, 175 equine herpesvirus 1, guinea pig, 220 Guinea Pig Cytomegalovirus (GPCMV), 219 Hamster Parvovirus (HPV), 176 Herpes simplex virus, rabbit, 259 K virus, mouse, 21 leporid herpesvirus 2, rabbit, 258 leporid herpesvirus 4, rabbit, 258, 259 Minute Virus of Mice (MVM), 18 Mouse Cytomegalovirus (MCMV), 15, 16

Mouse Thymic Virus (MTV), 17 polyomavirus

Mouse Polyoma Virus (MPyV), 20, 21 rabbit kidney vacuolating virus, 261 Rat Cytomegalovirus (RCMV), 122 Rat Polyomavirus (Rat-PyV), 122 Rat Virus, 124

infections of laboratory mice, effects on research,

12-13

Infectious Diarrhea of Infant Rats (IDIR), 129 infectious motor paralysis (Encephalitozoon), rabbit, 293 infertility

guinea pig, 241

mouse, 5, 89-90

rabbit, 253, 257

influenza virus, guinea pig, 220

insulinomas, guinea pig, 252 integumentary system guinea pig, 214 mouse, 5 rabbit, 254-255

interstitial cell tumor, testicular, rat, 169, 170

intestinal apical-tubular system, neonatal mouse, 7 intestinal coccidiosis

guinea pig, 236

mouse, 82-83

rabbit, 297-298

intestinal dysautonomia, rabbit, 273, 276

intestinal hemosiderosis, guinea pig, 246, 247

intestinal hyperplasia, adenomatous, guinea pig, 226

intestinal obstruction and rupture, rabbit, 307 intestinal plasmocytosis, rabbit, 308 intestinal spirochetosis, guinea pig, 223 intubation, tracheal injury, rabbit, 310 ionophore toxicity, rabbit, 316 iron deposition, spleen

mouse, 10

rabbit, 312

rat, 119

J

Japanese waltzing mice, 53

jelly hamsters, 195

jird, gerbil, 199

K

keratin, coryneforme hyperkeratosis, mouse, 67-69 keratitis

mouse, 69, 98

rat 126, 161-162

Sialodacryoadentitis Virus (SDAV), 126 keratoconjunctivitis, Corpnebacterium spp.-associated, mouse, 69

keratopathy, lipid (hypercholesterolemia), rabbit, 318 ketamine/xylazine

rabbit

cardiomyopathy, 316 iatrogenic nerve damage, 310 rat, corneal lesions, 162 kidney, see urinary System Kirsten sarcoma agent, rat, 129 Klebsiella spp.

guinea pig, 226

mouse, 62

rabbit, 279

rat, 142, 145

Klebsiella spp. hemorrhagic enterotyphlocolitis, rabbit, 279

Klossiella cobayae, guinea pig, 236

Klossiella muris, mouse, 83

Kupffer cell

gerbil, lead toxicity, 209

mouse

Helicobacter, 57, 101 histiocytic sarcoma, 110 rabbit, copper toxicosis, 315 Kurloff cell, guinea pig, 214-215 K virus, mouse, 21

L

labyrinthine hemochorial placentation, hamster, 174 lacrimal gland

mouse, Harderian gland neoplasia, 114

rat, 120

exorbital gland megalokarya/polykarya, 120

Rat Cytomegalovirus (RCMV), 122

Sialodacryoadenitis Virus (SDAV), 126

Lactate Dehydrogenase-elevating Virus (LDV), mouse, 25-26

lapine parvovirus, rabbit, 259

Large Granular Lymphocytic (LGL) leukemia, rat, 166-167

larval migrans, see helminth infestations, larval migrans larynx, syncytia, Mycoplasma pulmonis, mouse, 64 Lawsonia intracellularis

guinea pig (adenomatous intestinal hyperplasia), 226 hamster (transmissible ileal hyperplasia), 183-184, 185

mouse, 58

rabbit (proliferative enterocolitis, histiocytic enteritis), 279-280

rat, 139-140

LCMV, see Lymphocytic Choriomeningitis Virus (LCMV) LDV, see Lactate Dehydrogenase-elevating Virus (LDV) lead toxicosis

gerbil, 209

rabbit, 315-316

leiomyoma, uterine

gerbil, 210

guinea pig, 249, 251

leporid herpesvirus 1-4 (LHV-1, LHV-2, LHV-3, LHV-4), rabbit, 258-259

Leptospira spp. (leptospirosis)

gerbil, 203

guinea pig, 226, 227

hamster, 186

mouse, 62-63

rat, 142

Lepus spp., New and Old World hares, 253

Lethal Intestinal Virus of Infant Mice (LIVIM), 27 leukemia

gerbil, lymphocytic, 210

guinea pig, 251

mouse, 109

Murine Leukemia Virus (MuLV), 41-42 myeloid, 111

rat

Large Granular Lymphocytic (LGL), 166-167 lymphocytic, 167

rabbit, 320

leukocyte

gerbil, 199

guinea pig, 214-215

hamster, 174

mouse, 6

rat, 119

leukocytosis, rabbit, 255

Leydig cell tumor, rat, 169, 170

lice. see pediculosis

light cycle

hamster, 173

mouse, 89

rat, 161

limb amputation, Ectromelia Virus (ECTV), mouse,

22

lipidosis, see also hepatic lipidosis

guinea pig, islet cells, 248

lipoproteinosis, alveolar, mouse, 100

Listeria monocytogenes (listeriosis)

gerbil, 203

guinea pig, 226-227

rabbit, 280-281

liver, non-infectious, see also hepatitis

gerbil

amyloidosis, 208

lead toxicity, 209

guinea pig

amyloidosis, 243

cholangiofibrosis, chronic idiopathic, 247 contusions, 247 focal necrosis, 247

pregnancy toxemia (metabolic), 243

hamster, 174

amyloidosis, 194

hepatic cirrhosis, 196 polycystic disease, 195-196 mouse, 6, 7-8

aging-related disorders, 101 amyloidosis, 92 hematopoiesis, 6, 7-8 hepatocellular tumors, 113-114

myeloid leukemia, 111

Reye's-like syndrome, 95

rabbit, 256

aflatoxicosis, 316

bile duct tumors, 322

rat, 120

age-related changes, 156-157 atrophy of hepatic cords, 120 histiocytic sarcoma, 167-168

Large Granular Lymphocytic (LGL) leukemia, 166-167

LIVIM, Lethal Intestinal Virus of Infant Mice, 27 lung, non-infectious, see also pneumonia; respiratory system

gerbil, 200

guinea pig, 215-216

foreign body pneumonia, 245-246 neoplasia, 251

osseous metaplasia, 216 perivascular lymphoid nodules, 215, 216 pulmonary artery, 215

hamster, 174

alveolar histiocytosis, 196

mouse, 6

acidophil macrophage pneumonia, 94 disorders of, 99-100 metastasis of tumors, 108 neoplasia, 112-113 pulmonary histiocytosis, 100 rabbit, 255, 256

pulmonary artery smooth muscle, 256

tumor metastasis, 321

rat, 119

alveolar histiocytosis, 155 aspiration pneumonia, bedding, 162 eosinophilic granulomatous pneumonia, 160

luteal cell tumor, gerbil, 210

lymphadenitis

guinea pig

Streptobacillus moniliformis, 229

Streptococcus equi subsp. Zooepidemicus, 229

Streptococcus pneumoniae, 230

mouse

amyloidosis associated, 92

Mouse Norovirus (MNV), 32

Pasteurella pneumotropica, 65

Salmonella enterica, 59

Staphylococcus aureus, 70

Streptobacillus monilformis, 67

Streptococcus sp., 71

rat

Corynebacterium kutscheri, 140

Klebsiella pneumoniae, 142

Salmonella enterica, 140

lymph node

gerbil, amyloidosis, 208, 210

guinea pig

cavian leukemia, 251

see lymphadenitis, guinea pig

hamster

Hamster Polyomavirus (HaPyV), 177 lymphoma, 198

lymph node (Continued )

mouse, 9

Lymphocytic Choriomeningitis Virus (LCMV),

24, 25

lymphoma, 42, 43, 109, 110

mesenteric disease, 102

see lymphadenitis, mouse

rabbit

lymphosarcoma, 321, 322

myxoma virus, 263

rat

Large Granular Lymphocytic (LGL) leukemia, 166 lymphoma, 167 see lymphadenitis, rat

lymphocyte

gerbil, 199

guinea pig, 214-215, 216

hamster, 174

mouse, 6, 9

rabbit, 255

rat, 119

lymphocytic apoptosis, corticosteroid-induced, mouse, 11 lymphocytic Choriomeningitis Virus (LCMV) gerbil, 200 guinea pig, 220 hamster, 178 mouse, 23-25

lymphoid perivascular infiltrates, mouse, 100

lymphoid perivascular infiltrates, lung, guinea pig, 215-216 lymphoreticular neoplasia

gerbil, 210

guinea pig, cavian leukemia, 251

hamster

Hamster Polyomavirus (HaPyV)-associated, 176-178 lymphoma, 198

mouse, 109-111, 41-43

Burkitt-like (lymphoblastic) lymphoma, 110 diffuse large B-cell lymphoma, 110 follicular B-cell lymphoma, 110 histiocyte-associated diffuse large B-cell lymphoma, 110

histiocytic sarcoma, 110-111

Murine Leukemia Virus (MuLV) associated lymphomas, 41-42

Murine Mammary Tumor Virus (MMTV) associated lymphomas, 43

plasmacytoma, 110

precursor T-cell lymphoblastic lymphoma, 110 small B-cell lyphoma/leukemia, 109 small T-cell lymphoma, 110

splenic marginal zone lymphoma, 109

rabbit, 320, 321-322

lymphoma, cutaneous diffuse large B cell and T cell rich, 322

lymphosarcoma, 321

thymoma, 322

rat, 166-168

cutaneous, mycosis fungoides, 167 histiocytic sarcoma, 167-168

Large Granular Lymphocytic (LGL) leukemia, 166-167

lymphoma, 167

M

magnesium, dietary, guinea pig, 242 male

gerbil, 199 hyperadrenocorticism, 207 myocardial degeneration, 208 sexual dimorphism, 200

guinea pig, 213

genitourinary diseases, 249

hamster, adrenal glands, 174

mouse

aggression, 3, 90 genitourinary system, 8, 9, 104, 105 penis self mutilation, 91 reproductive tumors, 115

sexual dimorphism, 6, 8, 9, 10, 11

rabbit, 253

genital disorders, 310

Pasteurella multocida, 283

rat, 120, 121

interstitial cell tumor, 169

Rat Virus (RV) testicular hemorrhage, 123 malocclusion, dental

gerbil, 207

guinea pig, 246

hamster, 196

mouse, 100

rabbit

maxillary brachygnathia, 318-319 wet dewlap, 308

rat, 160

mammary fibroadenoma, rat, 164, 165, 166

mammary gland

guinea pig, 214

hamster, 174

mouse, 10

hyperplasia, FVB mouse, 97

rat, 120

Mammary Intraepithelial Neoplasia (MIN), mouse,112

mammary involution, male mouse, 10

mammary neoplasia

guinea pig, 250-251

mouse, 108, 111-112

Murine Mammary Tumor Virus (MMTV)- associated, 42-44

Polyoma Virus (PyV)-induced, 20

rabbit, 322

rat, 164, 165, 166

mange, see acariasis, mange mites

marking gland adenocarcinoma, gerbil, 210 masculinization, in utero, mouse, 8 mast cell, A strain mouse, spleen, 9 mastitis

guinea pig, 231

Escherichia coli, 226

Klebsiella pneumoniae, 226

Staphylococcus aureus, 228

hamster, 186

mouse, Pastuerella pneumotropica, 65

rabbit

cystic, 313, 322

Staphylococcus aureus, 285, 286

rat

Pastuerella pneumotropica, 142, 143

Staphylococcus aureus, 144

mastocytosis, systemic, gerbil, 210 mating behavior

hamster, 173

rabbit, 253, 254

maxillary brachygnathia, rabbit, 318 megacolon-syndrome of spotted rabbits, 319 megaesophagus, mouse, 101 megakaryocyte, mouse, 10 megaloglobus

rabbit, glaucoma/buphthalmia, 318

rat, 126

megaloileitis (Clostridium piliforme), rat, 137 megalokarya, mouse, 7 megalokaryocytosis, male reproductive epithelium, mouse, 104

melanoma, gerbil, 210 melanosis, mouse, 3, 9, 10 meningoencephalitis. see encephalitis/encephalomyelitis Meriones unguiculatus, Mongolian gerbil, 199 mesenchymal neoplasms

mouse

osteomas and osteosarcomas, 116

Polyoma Virus (PyV) associated, 20 rhabdomyosarcomas, 115, 116 mesenteric disease, mouse, 102 mesentery

Hamster polyomavirus (HaPyV)-induced lymphoma, 176-177 rat, polyarteritis nodosa, 156

Mesocricetus auratus (Syrian or golden hamster), 173 mesothelioma, rat, 169-170

metabolic disorders

gerbil, 206 guinea pig, 239 hamster, 193 rabbit, 313 metaplasia

gerbil, goblet cell, Citrobacter rodentium, 201

guinea pig

lung, osseous, 216

vagina, mucification, 217

hamster, gastric, Helicobacter aurati,182 mouse

lung, Mycoplasma pulmonis, 64

lung, Sendai virus, 33, 34

rabbit, tympanic bulla, Pasteurella multocida, 283 rat

auricular chondritis, 159 nasal, Aspergillus spp., 145 respiratory, Mycoplasma pulmonis, 135 salivary and lacrimal, Sialodacryoadenitis Virus (SDAV), 125, 126 metastatic mineralization

guinea pig, 242

rabbit, hypercalcemia, 313

metritis/endometritis

guinea pig

Bordetella bronchiseptica, 223

Streptococcus spp., 230

mouse

Klebsiella spp., 62

Mycoplasma pulmonis, 64

Pasteurella pneumotropica, 65

rabbit

Listeria monocytogenes, 281

Moraxella bovis, 281

Pasteurella multocida, 284, 285

Salmonella spp., 285

rat

Mycoplasma pulmonis, 136 persistant vaginal septum, 161

MHC complex, mouse, 11

MHG virus, Rat Theilovirus (RTV), 128-129

MHV, see Mouse Hepatitis Virus (MHV), 27 microbiome, cecal, rabbit, 254 microphthalmia, mouse, 3, 69, 99 microsporidia, see Encephalitozoon cunniculi; Enterocytozoon bieneusi; E. hellem

Microsporum canis, see dermatophytosis milkspots, mouse, 6

MIN, Mammary Intraepithelial Neoplasia, mouse, 112 Mink Cell Focus (MCF) forming virus, mouse, 41,42 Minute Virus of Mice (MVM), 17 mites. see acariasis

MMTV, see Murine Mammary Tumor Virus

MMTV-S (Standard), mouse, 42 molt, rabbit, 254

Mongolian gerbil, 199. see also gerbil

MoPn (Mouse Pneumonitis) agent, (Nigg agent), mouse, 60, 61

Moraxella bovis, rabbit, 281

Mouse, 1

Aging, degenerative, and miscellaneous disorders, 91-95

Multisystemic disorders, 91-95

Acidophilic macrophage pneumonia/ epithelial hyalinosis, 94

Amyloidosis and amyloid-like nasal deposition, 92

Dehydration, 91

Graft versus host diseases, 95

Hypothermia and hyperthermia, 91

Reye's-like syndrome, 95

Soft tissue calcification: cardiac calcinosis/ myocardial calcification, 93

Anatomic features, 5-11

Gastrointestinal system, 6

Genitourinary system, 8

Hematology and hematopoeitic system, 5 Immunologic idiosyncracies, 10

Integumentary system, 5

Other anatomic features, 10

Respiratory system, 6

Bacterial infections, 50-72

Acid fast Bacterial infections, 72

Mycobacterium spp. infections, 72

Bacterial enteric infections, 50-60

Brachyspira spp. infection, 50

Citrobacter rodentium infection: Transmissible

Murine Colonic Hyperplasia, 50

Mouse (Continued )

Clostridium difficile and Clostridium perfringes: Clostridial Enteropathy, 52

Clostridium piliforme infection: Tyzzer's disease, 53

Escherichia coli infection: coliform typhlocolitis, 54 Helicobacter spp. infections, 55 Lawsonia intracellularis infection, 58

Salmonella enterica infection: salmonellosis, 58 Segmented filamentous bacteria, 59 Other gram-negative bacterial infections, 60-67

Burkholderia gladioli infection, 60

Chlamydia spp. infection, 60

Cilia-associated respiratory bacillus infection, 61 Coxiella burnetii infection, 61

Klebsiella spp. infection, 62

Leptospira spp. infection: leptospirosis, 62

Mycoplasma spp. infections, 63-65

Hemotropic mycoplasma infections, 65

Respiratory and genital mycoplasmosis, 63

Pasteurella pneumotropica infection, 65

Proteus mirabilis infection, 66

Pseudomonas aeruginosa infection, 66 Streptobacillus moniliformis infection, 67

Other Gram-positive bacterial infections, 67-72

Aerococcus viridans infection, 67

Corynebacterium bovis infection: coryneform hyperkeratosis; scaly skin disease, 67

Corynebacterium kutscheri infection: pseudotuberculosis, 69

Other Corynebacterium spp.-associated disease, 69 Stapylococcus spp. infections, 69-71 Chronic suppurative inflammation, 70 Furunculosis, 70

Ulcerative dermatitis, 70

Streptococcus and Enterococcus infections, 71 Behavioral disorders, 89-91 Barbering and trichotillomania, 90 Infertility, 89

Male aggression, 90

Penis mutilation, 91

Stereotypy, 90

Common inbred strains, 3

Disorders of the cardovascular and respiratory systems, 99-100

Alveolar hemorrhage, 100

Aspiration pneumonia, 100

Atrial thrombosis and heart failure, 99

Freund's adjuvant pulmonary granulomata, 100 Perivascular lymphoid infiltrates, 99 Polyarteritis, 99

Pulmonary histiocytosis/lipoproteinosis, 100 Disorders of the central nervous system and sensory organs, 97-99

Blepharitis and conjunctivitis, 98

Central nervous system miscellany, 98

Corneal opacity, 98

Hydrocephalus, 98

Hypocallocity, 97

Microphthalmia and anopthalmia, 99

Retinal degeneration, 99

Seizures, 97

Vestibular syndrome, 98

Disorders of the endocrine system, 102

Disorders of the gastrointestinal system, 100-102

Cleft lip/palate, 100

Foreign body periodontitis: hair tooth, 100

Gastric mucosal hyperplasia, 101

Liver disorders, 101

Malocclusion, 100

Megaesophagus, 101

Mesenteric disease, 102

Disorders of the musculoskeletal system, 105-106

Fibro-osseous lesions in aged mice, 105

Lateral femoral triangle hernias, 106

Osteoarthritis and osteopenia, 105

Spinal fracture and posterior paresis, 105

Vertebral disk degeneration, 105

Disorders of skin, 95-97

Alopecia areata in C3H mice, 96

Alopecia in B6 mice, 96

Auricular chondritis, 96

Clown mouse syndrome, 96

Ear gangrene and notching, 96

Frostbite, 97

Mammary hyperplasia, 97

Mechanical muzzle alopecia, 95

Ringtail, 96

Sloughing of extremities due to cotton nesting material, 97

Disorders of the urogenital systems, 102-105

Adenomyosis, 104

Bulbourethral gland cysts, 104

Chloroform toxicity, 103

Chronic nephropathy, 102

Cystic endometrial hyperplasia, 104

Glomerulonephropathy/glomerulopathy, 102

Hydronephrosis, 102

Inclusion body nephritis, 103

Mucometra/hydrometra, 103

Murine urologic syndrome (MUS), 104

NSAIDS-associated nephropathy, 103

Polycystic disease, 103

Pseudocanalization and megakaryocytosis of male reproductive epithelium, 104

Renal infarction, 103

Renal tubular hyaline bodies, 103

Seminal vesicular dilatation and atrophy, 104

Fungal infections, 78-81

Dermatophytosis, 78

Encepalitozoon cuniculi: microsporidiosis, 79

Gastric candidiasis, 79

Pneumocystis murina infection: pneumocystosis, 79

Systemic and pulmonary mycoses, 79

Genomic considerations for the pathologist, 4

Infections of laboratory mice: effects on research, 12 Introduction, 1

Mouse genetics and genomics, 2

Neoplasms, 108-117

Endocrine neoplasms, 116

Harderian gland neoplasia, 114

Hepatocellular neoplasia, 113

Histiocytic sarcoma, 110

Lymphoid neoplasia, 109-110

Burkitt-like (lymphoblastic) lymphoma, 110

Diffuse large B-cell lymphoma, 110

Follicular B-cell lymphoma, 109

Histiocyte-associated diffuse large B-cell lymphoma, 110

Plasmacytoma, 110

Precursor T-cell lymphoblastic lymphoma, 110

Small B-cell lymphoma/leukemia, 109

Small T-cell lymphoma

Splenic marginal zone lymphoma, 109

Mammary neoplasia, 111

Mesenchymal neoplasms, 115

Myeloid leukemia, 111

Myoepithelioma, 114

Neoplasia of the Reproductive system, 115 Nonlymphoid hematopoietic neoplasms, 110 Osteomas and osteosarcoma, 116

Other mesenchymal tumors, 116

Other neoplasms, 117

Pulmonary neoplasia, 112

Rhabdomyosarcomas, 115

Signature GEM phenotypes: molecular pathology of neoplasia, 109

Teratomas: embryonal carcinomas/ teratocarcinomas, 115

Nomenclature, 2

Parasitic diseases, 82-89

Ectoparasitic infestations, 86-88

Follicle mite infestations, 87

Fur mite infestations: acariasis, 86

Louse infestation: pediculosis, 88

Ornthonyssus bacoti infestation, 88

Helminth infestations, 84-86

Pinworm infestations, 84

Tapeworm infestations, 85

Protozoal infections, 82-84

Cryptosporidium spp. infection: cryptosporidiosis, 82

Eimeria spp. infection: intestinal coccidiosis, 82

Giardia muris infection: giardiasis, 83

Klossiella muris infection: renal coccidiosis

Sarcocystis muris infection, 83

Spironucleus muris infection: spironucleosis, 83 Viral infections, 14-44

DNA viral infections, 14-23

Adenovirus infections, 14

Herpesvirus infection, 15

Mouse cytomegalovirus infection, 15

Mouse thymic virus infection, 17

Papillomavirus infections, 19

Parvovirus infections, 17

Polyomavirus infections, 19

K virus infection, 21

Polyoma virus infection, 19

Poxvirus infection: Ectromelia Virus (ECTV) infection; mousepox, 21

Retroelements and retrovirus infections, 38-44

Germline insertional mutagenesis, 41

Modulation of the host response by MuLV's and MMTV's, 41

Murine leukemia viruses, 41

Murine mammary tumor viruses, 42

RNA viral infections, 23-38

Arenavirus infection: lymphocytic choriomeningitis virus infection, 23

Arterivirus infection: lactate dehydrogenase­elevating virus infection, 25

Astrovirus, 26

Coronavirus infection: Mouse Hepatitis Virus (MHV) infection, 27

Norovirus infection, 31

Paramxovirus infections, 32

Picornavirus infection: mouse encephalomyelitis virus infection, 35

Pneumonia Virus of Mice (PVM) infection,

32

Reovirus infection, 36

Rotavirus infection: Epizootic Diarrhea of Infant Mice (EDIM), 37

Sendai virus infection, 33

Mouse Cytomegalovirus (MCMV), 15-17

Mouse Encephalomyelitis Virus (MEV) hamster, 179 mouse, 35-36

Rat Theilovirus (RTV), 128-129

Mouse Hepatitis Virus (MHV), 27-31

Mouse Models of Human Cancer Consortium

(MMHCC), 108, 109

Mouse Norovirus (MNV), 31-32

Mouse Papilloma Virus (MusPV), 19

Mouse Parvovirus (MPV), 17-19

mouse phenome database, 3

Mouse Pneumonitis (MoPn) agent, 60, 61

mouse poliovirus, see Mouse Encephalomyelitis Virus (MEV)

mouse pox, Ectromelia Virus, (ECTV), 21-23

Mouse Thymic Virus (MTV), 17

Mouse T-lymphotrophic virus, Mouse Thymic Virus

(MTV), 17

Mouse Urinary Protein (MUP-1), 8

MRM, Murine Respiratory Mycoplasmosis (MRM), rat, 134-136

MPV, Mouse Parvovirus, 17-19 mucoid enteropathy, rabbit, 306, 307 mucometra/hydrometra

mouse, 103-104

rabbit, 310, 311 multicentric lymphoma, mouse, 42, 43, 108,

109

multinucleated giant cells

guinea pig, foreign body pneumonia, 246

mouse

acidophilic macrophage pneumonia, 94 fibro-osseous lesion, 105 histiocytic sarcoma, 111

Mycoplasma pulmonis, 64

rabbit

deep mycoses, 296

lymphosarcoma, 322

Mycobacterium avium paratuberculosis, 282

Pasteurella multocida, 284

rat

Clostridiumpiliforme (Tyzzer's disease), 137 eosinophilic granulomatous pneumonia, 160 histiocytic sarcoma, 167, 168

multisystemic disorders, mouse, 91

mummification, fetal rabbit, listeriosis, 281

Murine Adenovirus type 1 (MAdV-1)

mouse, 14-15, 95

rat, 122

Murine Adenovirus type 2 (MAdV-2)

hamster, 175

mouse, 14-15

rat, 122

Murine Endogenous Retroelements (MuERVs), 39

Murine Leukemia Virus (MuLV), 26, 39, 40, 41-42, 44

Murine Mammary Tumor Virus (MMTV), 39-44, 111-112

Murine Norovirus-1 (MNV-1), 31-32

Murine Repeated Viruses on Y chromosome (MuRVYs),

39

Murine Respiratory Mycoplasmosis (MRM), rat, 134-136

Murine Retrovirus-Related Sequences (MuRRS), 39

Murine Sarcoma Virus (MuSV), 39

Murine Urologic Syndrome (MUS), mouse, 104 muromics, mouse, 1 muscular dystrophy

mouse, 105, 115

musculoskeletal system

guinea pig, 217 hypovitaminosis C, 239-241 metastatic mineralization, 242 myopathies, 241 nutritional myopathy, 241 osteoarthritis, 246

skeletal muscle degeneration and mineralization, 241 mouse, 9

auricular chondritis, 96

disorders of, 105

fibro-osseous lesions, bone, 105 lateral femoral triangle hernias, 106 muscular dystrophy, 105 osteoarthritis and osteopenia, 105 osteomas and osteosarcomas, 116 rhabdomyosarcoma, 115, 116

Sarcocystis muris, 83

soft tissue calcification, 93

spinal fracture and posterior paresis, 105 vertebral disk degeneration, 105

rabbit, 257 fluoroquinolone arthropathy, 316 ionophore toxicity, 316 nutritional secondary hyperparathyroidism, 314 osteofluorosis, 315

Sarcocystis cuniculi, 300

splay leg, 319

vertebral fracture, 309, 310

vitamin A toxicity or deficiency, 314

vitamin D toxicity or deficiency, 315

vitamin E deficiency, 315

rat, 120

auricular chondropathy, 159

osteoarthritis, degenerative, 159

Mus musculus, subspecies castaneus, domesticus, molossinus, musculus, 2

Mus spretus, 2

muzzle

mouse

furunculosis, 70

mechanical alopecia, 95

MVM, see Minute Virus of Mice (MVM) Mycobacterium avium-intracellulare, mouse, 72 Mycobacterium avium paratuberculosis (paratuberculosis), rabbit, 282

Mycobacterium bovis and M. tuberculosis, see Tuberculosis Mycobacterium chelonae

hamster, 186 mouse, 71

Mycoplasma spp.

guinea pig, 227-228

Mycoplasma caviae, 228

Mycoplasma cavipulmonis, 228

Mycoplasma pulmonis, 228

hamster, Mycoplasma pulmonis, 186 mouse, 63-65

Mycoplasma arthritidis, 63, 65

Mycoplasma coccoides, 63, 65

Mycoplasma collis, 63

Mycoplasma muris, 63

Mycoplasma haemomuris, 63, 65

Mycoplasma neurolyticum, 63

Mycoplasma pulmonis, 63-65

Mycoplasma rhavipulmonis (grey lung agent)

rat, 134-136, 142

Mycoplasma arthritidis, 134, 136

Mycoplasma haemomuris, 142

Mycoplasma pulmonis, 134-136 mycoplasmosis

mouse

hemotropic, 65

respiratory and genital, 63-65

rat

CAR bacillus coinfection, 133

Murine Respiratory Mycoplasmosis (MRM), 134-136 mycoses, see fungal infections mycosis fungoides

hamster, 198

rat, 167

myeloid leukemia, mouse, 111

myeloid ring nuclei

mouse, 6

rat, 119

myelopoiesis, mouse, 7, 8, 21, 71, 111 myiasis

hamster, 192

rabbit, 304

hutch burn-associated, 309

myocardial disorders

gerbil

Clostridium piliforme (Tyzzer's disease), 202-203 myocardial degeneration and fibrosis, 207 guinea pig

cardiac glycogenosis (rhabdomyomatosis), 241-242

myocardial degeneration, 229, 241

neoplasia, 252

hamster, myocardial degeneration, 194, 195 mouse

cardiac calcinosis, 3, 93-94

rabbit, 255

Clostridium piliforme (Tyzzer's disease), 275-276 coronaviral cardiomyopathy, 267 infarction, hypercholesterolemia, 314 ionophore toxicity, 316 ketamine/xylazine associated cardiomyopathy, 316 lead toxicosis, 316

rat

Clostridiumpiliforme (Tyzzer's disease), 137-138 myocardial degeneration/fibrosis, 155 pseudomoniasis, 143

subendocardial spindle cell proliferation, 156 myoepithelioma, mouse, 114, 115 myopathies

guinea pig, 241

cardiac glycogenosis (rhabdomyomatosis), 241-242 metastatic mineralization, 242

nutritional, 241

myocardial and skeletal muscle degeneration, 241 mouse, muscular dystrophy, 105 rabbit, nutritional, 315

myxomatosis, rabbit, 261-263

myxomatosis, amyxomatous form, rabbit, 263

N

Nasal-Associated Lymphoid Tissue (NALT), mouse, 9 nasal dermatitis (sore nose), gerbil, 206 nasal epithelial hyalinosis, mouse, 94 nasal mite (Speleorodens clethrionomys), hamster, 191 nasal turbinates

mouse, amyloid-like deposition, 93

rabbit, atrophy, Pasteurella multocida, 283, 284

rat, Mycoplasma pulmonis, 135

nasal worm (Trichosomoides nasalis), hamster, 190

Natural Killer (NK) cell

guinea pig, 214

mouse, deficiency, 11

rat, Large Granular Lymphocytic (LGL) leukemia, 166 necrobacillosis (Fusobacterium necrophorum)

rabbit, 278-279

wet dewlap, 308

necrotizing dermatitis, staphylococcal, mouse, 70, 71 nematodes, gastrointestinal. see helminth infestations nematodes, larval migrans. see helminth infestations neonate

hamster

Hamster Parvovirus (HaPV), 175, 176 spontaneous hemorrhagic necrosis, 193 mouse

Epizootic Diarrhea of Infant Mice (EDIM), 37-38 gastrointestinal system, 7 immunodeficiency, 10

liver, 8

mouse hepatitis virus, Lethal Intestinal Virus of Infant Mice, (LIVIM), 27

rabbit, immunity, 256

rat

enterococcal enteropathy, 138-139

Infectious Diarrhea of Infant Rats (IDIR), 129 neoplasia

gerbil, 209

adrenocortical tumors, 210

dysgerminoma, 210 granulosa cell tumor, 210

Helicobacter pylori-associated, 210

leiomyoma, 210

luteal cell tumor, 210

melanoma, 210

squamous cell carcinoma, 210 ventral marking gland tumors, 210 guinea pig, 250

cardiovasular neoplasia, 252

cavian leukemia, 251 cutaneous neoplasia, 250 endocrine neoplasia, 252 leiomyoma, 251

mammary neoplasia, 250-251 other neoplasms, 252 pseudo-odontoma: odontoma, 251 reproductive tract neoplasia, 251 respiratory tract neoplasia, 251 trichoepithelioma/trichofolliculoma, 250 hamster, 197

adrenocortical adenomas, 198

Hamster Polyomavirus (HaPyV) induced lymphoma, 177 trichoepithelioma, 177

lymphoma

epidermotropic, 198 spontaneous, 198 mouse, 108

AKR mouse, 42

B6 mice, 3

BALB mouse, 3, 42

B cell, 109-110

C3H/He mouse, 5, 111

DBA mouse, 113

endocrine, 116-117

FVB/N mouse, 3

GEMs, 5, 109

Harderian gland, 114 hepatocellular, 113-114 histiocytic sarcoma, 110-111 inbred mice, 3-4, 108 lymphoid, 109-110

Burkitt-like (lymphoblastic) lymphoma, 110 diffuse large B-cell lymphoma, 110 follicular B-cell lymphoma, 109-110 histiocyte-associated diffuse large B-cell lymphoma, 110

plasmacytoma, 110

precursor T-cell lymphoblastic lymphoma, 110 small B-cell lymphoma/leukemia, 109 small T-cell lymphoma

splenic marginal zone lymphoma, 109 mammary, 111-112 mesenchymal neoplasms, 115 molecular pathology of neoplasia, 109 Murine Leukemia Virus (MuLV), 41-42 Murine Mammary Tumor Virus (MMTV), 42-44 myeloid leukemia, 111 myoepithelioma, 114, 115 reproductive system, 115 nonlymphoid hematopoietic, 110 129/Sv mouse, 3, 115 osteomas and osteosarcoma, 116

neoplasia (Continued )

pituitary, 116 pulmonary neoplasia, 112-113 rhabdomyosarcomas, 115, 116

SCID mouse, 109

T cell, 110

teratomas, embryonal carcinomas/ teratocarcinomas, 115

thymic lymphoma, 109

rabbit, 320

bile duct adenomas and adenocarcinomas, 322 lymphosarcoma, 320-322

mammary adenomas and carcinoma, 322 pituitary adenoma, prolactin-secreting, 313 pseudo-odontoma, 322-323

thymoma, 322

uterine adenocarcinoma, 320, 321

rat, 164

cutaneous lymphoma: mycosis fungoides, 167 histiocytic sarcoma, 167-168

Large Granular Lymphocytic (LGL) leukemia, 166, 167

lymphoma and lymphocytic leukemia, 167 lymphoreticular tumors, 165 mammary adenocarcinoma, 166 mammary fibroadenoma, 164-166 mesothelioma, 169-170

pituitary gland adenoma, 168-169 preputial gland tumor, 164, 165 testicular interstitial cell tumor, 169, 170 Zymbal's gland tumor, 164, 165 nephritis

guinea pig, Encephalitozoon cuniculi, 234 hamster, Leptospira spp., 186

mouse

Encephalitozoon cuniculi, 79 inclusion body, 103

Leptospira spp., 62

Murine Urologic Syndrome (MUS), 104 rabbit

Encephalitozoon cuniculi, 293-295

Staphylococcus aureus, 286

rat

bacterial, 145

Leptospira spp., 142 nephrocalcinosis

rabbit, 311

telazol nephrotoxicity, 316

rat, 158 nephropathy

gerbil, lead toxicity, 209

mouse

chronic progressive, 102

NSAIDS-associated nephropathy, 103

rat

chronic progressive, 157-158

NSAIDS-associated nephropathy, 162 nephrosclerosis, guinea pig, 247-248 nerve damage, iatrogenic, rabbit, 310 nervous system

gerbil, cerebral ischemia, 200

guinea pig

Clostridium botulinum, 276

nematode larval migrans, 237

hamster

cerebral mineralization, 196

Hamster Parvovirus (HPV), 175-176 hydrocephalus, 197

spontaneous hemorrhagic necrosis of fetal hamsters, 193

mouse 10, 98

cerebellar hypoplasia, 18

hydrocephalus, 98

hypocallosity, 97-98

Mouse Encephalomyelitis Virus (MEV), 35-36

Mouse Hepatitis Virus (MHV), 29, 30

seizures, post-ictal necrosis, 97

rabbit, 255

Baylisascaris spp. larval migrans, 300-301

Encephalitozoon cuniculi, 293-295

rat

degenerative changes, 154

hydrocephalus, 160 radiculoneuropathy, 154-155 Rat Theilovirus (RTV), 128-129 Rat Virus (RV), 123-124

neutrophil

guinea pig, 214

hamster, 174

mouse, 6

rabbit, 255

New Zealand White (NZW) rabbit, 253

atherosclerosis, 314

buphthalmia, 318

cataracts, 318

gastric pyloric hypertrophy, 307

maxillary brachygnathia, 319

skeleton, 257

uterine adenocarcinoma, 320, 321 nictitating membrane protrusion, gerbil, 215 night feces, rabbit, 254

NK cell, see Natural Killer (NK) cell

NOD (Non-Obese Diabetic), mouse, 4, 10

autoimmunity, 4

cataracts, 4

C5a deficiency, 4

diabetes, type 1, 4

graft vs. host disease, 4, 95

IgG2c, 10

NK cell deficiency, 4

NKT cell deficiency, 4

NSG: NOD.Cg-Prkdc^scidIL2rg^tm1wjl/SvJ, 4

regulatory CD4+CD25+ deficiency, 4

nomenclature, mouse and rat international guidelines, 2 Non-Obese Diabetic (NOD), see NOD

Norovirus (MNV), mouse, 31-32

Notoedres spp., see acariasis

NSAIDS-associated nephropathy

mouse, 103

rat, 162

NSG mouse, 4

nude mouse, 11

nutritional disorders

guinea pig, 239-240

myopathy, 241

hamster, 193

rabbit, 313

NZW, New Zealand White (NZW) rabbit, 253

O

obesity

gerbil, 207, 208

guinea pig, pregnancy toxemia, 243 hamster, hyperadrenocorticism, 193 rabbit, pregnancy toxemia, 313 obstructive uropathy (Murine Urologic Syndrome), 8, 104

obturator nerve paralysis, guinea pig, 249 ocular cataracts, rabbit, 318 ocular proptosis, gerbil, 207 odontoma/pseudo-odontoma

guinea pig, 251

rabbit, 322-323

oily hair effect (steatorrhea), mouse, 37, 38 old rat nephropathy, 157-158

129 mouse, 3, 4, 5

acidophilic macrophage pneumonia, 94 chimerism, 5

cochlear degeneration, 98 conjunctivitis/blepharitis, 98 cystic Muellerian ducts, 5 embryonic stem cells, 4-5 epithelial hyalinosis, 6, 94 glomerulonephritis, 102 Harderian gland tumors, 3, 114 hemangiosarcoma, 3, 115 hermaphrodism, 5 hypocallosity, 97-98 megaesophagus, 101 ovarian tumors, 3, 115 ovotestes, 5 pulmonary adenomas, 3, 112 teratomas, 115, 116 testicular hypoplasia, XX/XY chimeras, 5 orchitis

gerbil, Salmonella enterica, 203

rabbit

Brucella spp., 272

Pasteurella multocida, 285

Ornithonyssus bacoti, see Acariasis Ornithonyssus sylvarium, see Acariasis Oryctolagus cuniculus, rabbit, 253. see also Rabbit osteitis, Actinomyces sp., rabbit, 271 osseous metaplasia, pulmonary, guinea pig, 216 osteoarthritis

guinea pig, 246

mouse, 105

rat, 159 osteofluorosis, rabbit, 315 osteoma/osteosarcoma, mouse, 116 otitis media

guinea pig, 231 mouse

Burkholderia gladioli, 60

Mycoplasma pulmonis, 64 Pasteurella pneumotropica, 65

Pseudomonas aeruginosa, 66

Sendai virus, 34

rabbit, Pasteurella multocida, 283, 284, 285

rat

Mycoplasma pulmonis, 134 Pasteurella pneumotropica, 143 Streptococcus pneumoniae, 145 outbred strains, mouse, 2, 4 outbred Swiss mouse, 4 oval cell, mouse, 57, 101 ovarian cyst

gerbil, 208

guinea pig, 245, 249, 251

ovarian tumors

gerbil dysgerminoma, 210 granulosa cell tumor, 210

guinea pig, 251

mouse, 115

P

pancreas

gerbil, diabetes, 207

guinea pig, fatty infiltration of, 247, 248

hamster, diabetes mellitus, 193

rabbit, 256

rat, 120

pancreatic islet hypertrophy and fibrosis, 157

Paneth cells

hamster, 174

mouse, 7

rat, 119

papillomavirus

Hamster papilloma viruses (MsPV1, PsPV1), 175

Mouse Papilloma Virus (MusPV), 19

rabbit

Cottontail Rabbit Papilloma Virus (CRPV),

260

Rabbit Oral Papilloma Virus (ROPV), 260-261

Rat Papilloma Viruses (RnPV-1, RnPV-2), 122 paramyxoviruses

guinea pig

PIV-1 (Sendai virus), 220

PIV-2 (Simian virus-5, SV-5), 220

PIV-3 (GpPIV-3, CavPIV-3), 220-221

Pneumonia Virus of Mice (PVM), 220

hamster

Pneumonia Virus of Mice (PVM), 178

Sendai virus, 178-179

SV-5, 179

mouse, 32

Pneumonia Virus of Mice (PVM), 32-33

Sendai virus, 33-35

rabbit, Sendai virus, 267

rat, 127

Parainfluenza Virus 3 (PIV-3), 128

Pneumonia Virus of Mice (PVM), 128 Sendai virus, 128 paralysis of peristalsis of lactating mice, 53 parasitic diseases, see protozoal infections; helminth infestations; acariasis; pediculosis, fleas, and myiasis

parathyroid gland

guinea pig, 215

mouse, 9

rabbit, nutritional secondary hyperparathyroidism, 314 paratuberculosis, enteric (Mycobacterium avium paratuberculosis), rabbit, 282

paresis, posterior

guinea pig, obturator nerve paralysis, 249

mouse, spinal fracture, 105

rabbit, vitamin D toxicity, 315

rat, radiculoneuropathy, 154-155

Parker's Rat Coronavirus (PRC), 125 parotid salivary gland

mouse, 6

myoepithelioma, 114, 115

rat

Rat Polyomavirus (Rat-PyV), 122

Sialodacryoadentitis Virus (SDAV), 125, 126 parotid tumor virus (Polyoma Virus, PyV), mouse, 19 parturition, rabbit, 253

parvovirus

Hamster Parvovirus (HaPV), 175-176, 196 mouse

Minute Virus of Mice (MVM), 17-19

Mouse Parvovirus (MPV), 17-19

rabbit, lapine parvovirus, 259

rat

Toolan H-1 virus, 122

Rat Parvovirus (RPV), 122-124

Rat Virus (RV), 122-124

Pasteurella multocida

guinea pig, 228

mouse, 65

rabbit, 283-285

Pasteurella pneumotropica

hamster, 186

mouse, 65-66

bulbourethral gland cysts, 104

conjunctivitis, 98

rat, 142-143

Pasteurella ureae, mouse, 65

Pasteurellacaeae, V-factor-dependent, rat, 141, 142 pediculosis (louse infestation)

guinea pig

Gliricola porcelli, 238

Gyropus ovalis, 238

Trimenopon hispidum, 238

mouse, Polyplax serrata, 65, 88

rabbit, Hemodipsus Ventriculosis, 304

rat

Hoplopleura pacifica, 153

Polyplax spinulosa, 153

peg teeth, rabbit, 256

peliosis hepatis, rat, 156

penis

guinea pig, 216

mouse

male aggression, 90

self mutilation, B6, 91

pericarditis

guinea pig

Klebsiella pneumoniae, 226

Pasteurella multocida, 228

Streptococcus equi subsp. Zooepidemicus, 229

rabbit, Pasteurella multocida, 284

rat, Streptococcus pneumoniae, 144 periodontal disease

gerbil, 206-207

hamster, 196

mouse, foreign body periodontitis (hair tooth), 100, 101 peristalsis, paralysis of, mouse, 53 perivascular lymphoid infiltrates, mouse, 99 perivascular lymphoid nodules, lung, guinea pig, 215, 216 Peyer's patches

guinea pig, 216

mouse, 6, 59, 321

rabbit, 255

pheochromocytoma, gerbil, 208 phenotyping, mouse

phenome database, 3, 5

resources, 1

phosphorus, dietary, guinea pig, metastatic mineralization, 242

physiologic features

guinea pig, 214

rabbit, 254

picornavirus

guinea pig, 221

hamster, 179

mouse, Theiler's Mouse Encephalomyelitis Virus (TMEV), 35-36

Rat Theilovirus (RTV), 128

pinworms, see helminth infestations, pinworms pituitary gland adenoma

mouse, 3, 102, 116-117

rabbit, 313

rat, 168-169

placentation

gerbil, 200

guinea pig, 217

hamster, 174

mouse, 8

rabbit, 256

plague (Yersinia pestis), rabbit, 288 plasmacytoma, mouse, 110 plasmacytosis, intestinal, rabbit, 308 platelets, mouse, 6

pleural effusion disease virus, rabbit, 267 pleuritis

guinea pig

Citrobacter freundii, 224

Klebsiella pneumoniae, 226

Streptococcus equi subsp. Zooepidemicus, 229

Streptococcus pneumoniae, 230

rabbit

Pasteurella multocida, 284

rabbitpox virus, 264

rat, Streptococcus pneumoniae, 145 pneumococcus, see Streptococcus pneumoniae pneumoconiosis, guinea pig, 245-246 Pneumocystis spp. see fungal infections (mycoses) pneumonia

guinea pig

adenoviral pneumonia, 218

Bordetella bronchiseptica, 223

Corynebacterium kutscheri, 225

foreign body pneumonia, 245-246

Mycobacterium spp., 227

Parainfluenza virus, 220

Pasteurella multocida, 228

Pneumocystis sp., 234

Streptococcus pneumoniae, 230

hamster

Pneumonia Virus of Mice (PVM), 178

Salmonella enterica, 185

Sendai virus, 178-179

mouse

acidophil macrophage pneumonia, 94 aspiration, 100

Bordetella hinzii, 60

Cilia-Associated Respiratory (CAR) bacillus, 61

Chlamydia spp., 60

Corynebacterium kutscheri, 69

K virus, 21

Klebsiella pneumoniae, 62

Mouse Hepatitis Virus (MHV), 27

Mouse Norovirus, 31

Mycobacterium sp., 72

Mycoplasma pulmonis, 64-65 mycoses. see Fungal infections Pasteurella pneumotropica, 65 Pneumocystis murina, 79-81 Pneumonia Virus of Mice (PVM), 32

Sendai virus, 33-35

rabbit

Acinetobacter calcoacetius, 271

Aspergillus spp., 292

Bordetella bronchiseptica, 271

Chlamydophila sp., 272

Cilia-Associated Respiratory (CAR) bacillus, 273 leporid herpesvirus 2, 258

Mycobacterium spp., 282 myxoma virus (myxomatosis), 263 paramyxovirus, 267

Pasteurella multocida, 283

Pneumocystis oryctolagi, 296

Rabbit Hemorrhagic Disease (RHD), 264 rat

alveolar histiocytosis, 155 aspiration pneumonia, bedding, 162 Blastomyces dermatitidis, 145 Bordetella bronchiseptica, 132

Cilia-Associated Respiratory (CAR) bacillus, 133-134

Corynebacterium kutscheri, 140-141

Cow Pox Virus (CPXV), 124

eosinophilic granulomatous pneumonia, 160

Mycoplasma pulmonis, 135, 136

Parainfluenza Virus 3, 128

Pasteurella pneumotropica, 143

Pneumocystis carinii, 146

Pneumocystis wakefieldiae, 146

Pneumonia Virus of Mice (PVM), 128

Pseudomonas aeruginosa, 143

Rat Polyomavirus (Rat-PyV), 122

Sendai virus, 128

Sialodacryoadenitis virus (SDAV), 125

Streptococcus pneumoniae, 144

Pneumonia Virus of Mice (PVM)

gerbil, 200

guinea pig, 220

hamster, 178

mouse, 32-33, 80

rat, 128

pododermatitis

guinea pig, 228

rabbit (sore hocks), 286, 309 poisonous plant toxicity, rabbit, 316 poliomyelitis, Mouse Encephalomyelitis Virus (MEV), 35-36

polyarteritis

mouse, 98, 99

rat, 156

polychromasia, erythrocytic

gerbil, 199

hamster, 174

mouse, 6

rabbit, 255

polycystic kidney disease, mouse, 103

polycystic liver disease, hamster, 195-196 polykarya

mouse, liver, 7, 101

rabbit, liver, 256

rat, exorbital lacrimal gland, 120-121 polyomavirus

Hamster Polyomavirus (HaPV), 176-178, 197 mouse

K virus, 19-21

Polyoma Virus (PyV), 19-21

rabbit kidney vacuolating virus, 261

Rat Polyomavirus (Rat-PyV), 122 polyoma virus oncogenesis, mouse, 19 polyploidy, liver

mouse, 7, 101

rat, 120, 156

posterior paresis, see paresis

poxvirus

guinea pig pox virus, 220

mouse, Ectromelia Virus (ECTV), 21-23

rabbit, 261-264

hare fibroma virus, 264

myxoma virus (myxomatosis), rabbit, 261

rabbit fibroma virus, 263

rabbit pox virus (vaccinia), 264

rat, Cow Pox Virus (CPXV), 124

PRC, see Parker's Rat Coronavirus (PRC)

precursor T cell lymphoblastic lymphoma, mouse, 110

pregnancy disorders, guinea pig, 249 pregnancy toxemia

guinea pig, 243

circulatory/toxic form, 243 metabolic form, 243

hamster, 193-194

rabbit, 313

preputial adenitis, mouse, 69

preputial gland tumors

mouse, 115

rat, 164, 165

prognathism, mandibular, rabbit, 318 progressive glomerulosclerosis, rat, 157-158 Progressive Multifocal Leukoencephalopathy (PML), polyoma virus, mouse, 20

prolactin

mouse

mammary hyperplasia/tumors, 3, 10, 97, 102, 111

pituitary gland adenoma, 116-117

rat

chronic progressive nephropathy, 157 fibroadenoma, 164

pituitary gland adenoma, 168

proliferative enterocolitis (Lawsonia intracellularis) mouse, 58-59

rabbit, 272, 279-280 proliferative ileitis (Lawsonia intracellularis), hamster, 183-184

proteinuria

mouse, 8

rat, 120, 157, 158

Proteus mirabilis, septicemia, mouse, 66

Proteus spp., rat, 145 proto-oncogene, mouse, 41 protozoal infections

gerbil, 204-205

Cryptosporidium spp., 204-205

Giardia duodenalis, 205 non-pathogenic protozoa, 205

guinea pig, 235-237

Balantidium coli, 237

Cryptosporidium wrairi, 235-236

Eimeria caviae (intestinal coccidiosis),

236

Giardia duodenalis, 237

Klossiella cobayae (renal coccidiosis), 236

Toxoplasma gondii, 236-237 non-pathogenic protozoa, 237 hamster, 188-190

Cryptosporidium spp., 188-189

Giardia muris (giardiasis), 189

Spironucleus muris, 189-190 non-pathogenic protozoa, 190 mouse, 82-84

Cryptosporidium spp., 82

Eimeria spp. (intestinal coccidiosis), 82-83

Giardia muris, 83

Klossiella muris (renal coccidiosis), 83

Sarcocystis muris, 83

Spironucleus muris (spironucleosis), 83-84

Toxoplasma gondii, 82

Tritrichomonas muris, 82 non-pathogenic protozoa, 82 rabbit, 297-300

Cryptosporidium cuniculus, 297

Eimeria spp. (intestinal coccidiosis), 297-298

Eimeria steidae (hepatic coccidiosis), 298-300

Giardia duodenalis, 300

Hepatozoon cuniculi, 300

Sarcocystis cuniculi, 300

Toxoplasma gondii, 300

Trypanosoma nabiasi (trypanosomiasis), 300

nonpathogenic protozoa, 300

rat, 151-152

Cryptosporidium spp., 152

Eimeria spp.(intestinal coccidiosis), 151

Frenkelia spp., 151

Giardia muris, 151

Hammondia hammondii, 151

Hepatozoon muris, 151

Sarcocystis spp., 151

Spironucleus muris, 151

Toxoplasma gondii, 151

Trypanosomi lewisi (trypanosomiasis), 152 non-pathogenic protozoa, 151

pruritus

guinea pig

dermatophytosis, 234

ectoparasites, 237-238

mouse

ectoparasites, 86, 88

Staphylococcus spp., 70

rabbit

ectoparasites, 302-304 exfoliative dermatosis, 309 rat, ectoparasites, 153-154 pseudocanalization, male reproductive epithelium, mouse, 104

Pseudomonas aeruginosa

guinea pig, 228

mouse, 66-67

MCMV synergism, 16

rabbit (green fur syndrome), 285 rat, 127, 143, 145

pseudo-odontoma

guinea pig, 251

rabbit, 322-323

pseudopregnancy, rabbit, 253

pseudotuberculosis, see Corynebacterium kutscheri pseudotuberculosis (Yersinia pseudotuberculosis) guinea pig, 230-231

hamster, 186

rabbit, 288

psoroptic mange, (ear canker), rabbit, 303

pubic symphisis, guinea pig, 217, 249

pugilism

gerbil, 199

guinea pig, 213

hamster, 173

mouse, 90 rabbit, 253, 309 pulmonary adenocarcinoma, mouse, 112-113 pulmonary adenoma

guinea pig, 251 mouse, 108, 112, 113

tumor-associated amyloid, 92

pulmonary alveolar hemorrhage, agonal, mouse, 100 pulmonary alveolar histiocytosis

mouse, 100

rat, 155

pulmonary alveolar lipoproteinosis, mouse, 100 pulmonary artery, segmental smooth muscle, guinea pig, 215

pulmonary artery, smooth muscle, rabbit, 256

pulmonary granulomas

guinea pig, 246

mouse, 72, 100

rabbit, 282, 292

pulmonary histiocytosis, mouse, 100

pulmonary neoplasia

guinea pig, 251

mouse, 112-113

rabbit, metastatic uterine adenocarcinoma, 320 pulmonary perivascular lymphocyte cuffing, guinea pig, 215, 216

pulmonary vein, cardiac muscle, mouse, 6 pulmonary venous thrombosis (salmonellosis), hamster, 185

PVM, see Pneumonia Virus of Mice pyelonephritis

guinea pig, 248

mouse, 67, 72, 103

rabbit, 311

rat, 145

pyloric muscular hypertrophy, rabbit, 307 pyoderma, streptococcal, rabbit, 286 pyometra

mouse, cystic endometrial hyperplasia, 104

rabbit, Pasteurella multocida, 284, 285

Q

Q fever (Coxiella burnettii), mouse, 61-62

R

Rabbit, 253

Aging and miscellaneous disorders, 308-312 Amyloidosis, 311

Endometrial venous aneurysms, 310

Exfoliative dermatitis and sebaceous adenitis,

309

Hair chewing: barbering, 308

Hutch burn, 309

Iatrogenic nerve damage, 310

Miscellaneous genital disorders, 310

Miscellaneous kidney disorders, 311 Pododermatitis: sore hocks, 309

Prolapse of the deep gland of the third eyelid, 309 Splenic hemosiderosis, 312

Tooth abscesses, 309

Tracheal injury following intubation, 310

Urinary sludge and urolithiasis, 310

Vertebral fracture and degenerative spinal disease, 309

Wet dewlap: slobbers, 308

Bacterial infections, 271-288

Acintobacter calcoaceticus infection, 271 Actinobacillus spp. infection, 271 Bordetella bronchiseptica, 271

Brucella spp. infection: brucellosis, 272 Campylobacter spp. infection, 272 Chlaamydophila spp. infection, 272 Cilia-associated respiratory (CAR) bacillus infection, 272

Clostridial diseases, 273-277

Clostridium botulinum dysautonomia: grass sickness, 276

Clostridium difficile, Clostridium perfnngens, and Clostridium spiroforme: Clostridial enteropathy, 273

Clostridium piliforme infection: Tyzzer's disease, 275

Clostridium perfnngens: epizootic rabbit enteropathy, 276

Corynebacterium bovis infection, 273

Escherichia coli infection:colibacillosis, 277-278

Enterohemorrhagic Escherichia coli, 278

Enteropathogenic Escherichia coli, 277

Francisella tularensis infection: tularemia, “rabbit fever”, 278

Fusobacterium necrophorum infection: Schmorl's disease, necrobacillosis, 278

Helicobacter spp. infection, 279

Klebsiella spp. infection, 279

Lawsonia intracellularis infection: proliferative enterocolitis/histiocytic enteritis, 279

Listeria monocytogenes infection: listeriosis, 280 Moraxella bovis infection, 281

Mycobacterium spp. infection: tuberculosis, paratuberculosis, 282

Paratuberculosis, 282

Tuberculosis, 282

Pasteurella multocida infection: pasteurellosis; “snuffles”, 283

Pseudomonas aeruginosa infection, 285

Salmonella spp. infection: salmonellosis, 285

Staphylococcus aureus infections: Staphylococcosis, 285

Streptococcus spp. infection, 286

Treponema paraluis-cuniculi infection: rabbit syphilis, 287

Yersinia pseudotuberculosis infection: pseudotuberculosis, yersiniosis, 288

Behavioral, physiologic and anatomic features, 253-257 Anatomic features, 254-257

Cardiovascular system, 255

Central nervous system, 255

External features, 254

Gastrointestinal system, 256

Hematology/clinical chemistry, 255

Lymphoid system, 255

Musculoskeletal system, 257

Respiratory system, 255

Urogenital system, 256

Behavioral features, 253

Physiologic features, 254

Fungal infections, 292-296

Aspirgillus spp. infection: aspirgillosis, 292

Deep mycosis, 296

Dermatophytosis: ringworm, 292

Encephalitozoon cuniculi infection, encephalitozoonosis; Microsporidiosis, 293

Malassezia spp. infection: malasseziasis, 295

Pneumocystis oryctolagi sp. nov. infection, 295 Genetic disorders, 318-319

Anterior corneal dystrophy, 318

Congenital glaucoma:buphthalmia, 318 Malocclusion, 318

Megacolon-syndrome of spotted rabbits, 319

Ocular cataracts, 318

Rabbit (Continued )

Polycystic kidney disease, 319 splay leg, 319

Introduction, 253

Neoplasms, 320-323

Bile duct adenomas and adenocarcinomas, 322

Lymphosarcomadymphoma, 320

Mammary adenomas and carcinomas, 322

Other neoplasms, 323

Pseudo-odontoma, 322

Thymoma, 322

Uterine adenocarcinoma, 320

Noninfectious gastrointestinal disorders, 306-308

Anorectal polyps, 308

Biliary hyperplasia, 308

Gastric dilation (bloat) and gastrointestinal stasis, 306

Gastric pyloric hypertrophy, 307

Gastric ulceration, 307

Hepatic lobe torsion, 308

Intestinal obstruction and rupture, 307

Intestinal plasmacytosis, 308

Mucoid enteropathy, 306

Trichobezoar: hairball, 307

Nutritional, metabolic, and toxic disorders, 313-316

Aflatoxicosis, 316

Atherosclerosis/hypercholesterolemia, 314

Copper toxicosis, 315

Cystic mastitis, 313

Drug toxicoses, 316

Antibiotic “toxicity”, 316

Cardiomyopathy associated with ketamine/xylazine administration, 316

Fluoroquinolone arthopathy, 316

Ionophore toxicity, 316

Telazol nephrotoxicity, 316

Fluoride toxicosis: osteofluorosis, 315

Hypercalcemic arteriosclerosis, 313

Hypocalcemic tetany in lactatig does, 313

Lead toxicosis, 315

Nutritional secondary hyperparathyroidism, 314

Poisonous plant toxicity, 316

Pregnancy toxemia, 313

Vitamin A toxicity or deficiency, 314

Vitamin D toxicity or deficiency, 315

Vitamin E deficiency, 315

Xanthomatosis/hypercholesterolemia, 314

Parasitic diseases, 297-304

Ectoparasite infestations, 302-304

Cheyletiella parasitovorax infestation, 302

Demodex cuniculi infestation: demodectic

mange, 303

Fleas, 304

Haemodipsus Ventriculosis infestation:

pediculosis, 304

Leporacarus gibbus infestation, 303

Myiasis, 304

Psorobia lagomorpha infestation, 303

Psoroptes cuniculi infestation: Psoroptic mange; ear canker, 303

Sarcoptes scabei infestation: scabies, 303

Trombiculid mite infestation: chiggers, 303

Helminth infestations, 300-302

Baylisascaris spp. larval migrans, 300

Capillaria hepatica infestation, 301

Dirofilaria spp. infestation, 301

Other gastrointestinal helminth infestations, 302

Passalurus ambiguus infestation: pinworms, 301

Tapeworm infestations, 302

Toxacara canis infestation, 301

Protozoal infections, 297-300

Cryptosporidium cuniculus infection: cryptosporidiosis, 297

Eimeria spp. infections, 297

Giardia duodenalis infection, 300

Hepatic coccidiosis, 298

Hepatozoon cuniculi infection, 300

Intestinal coccidiosis, 297

Nonpathogenic (commensal) intestinal protozoa, 300

Sarcocystis cuniculi infection, 300

Toxoplasma gondii infection: toxoplasmosis, 300

Trypanosoma nabiasi infection: trypanosomiasis, 300 Viral infections, 257-269

DNA viral infections, 257-264

Adenovirus infection, 257

Cottontail rabbit papillomavirus (CRPV) infection, 260

Hare fibroma virus infection, 264

Herpes simplex virus infection, 259

Herpesvirus infection, 258

Lapine Parvovirus infection, 259

Leporid herpesvirus 1 and 3 infection, 258

Leporid herpesvirus 2 infection, 258

Leporid herpesvirus 4 infection, 258

Myxoma virus infection: myxomatosis, 261

Papillomavirus infections, 260

Polyomavirus infection, 261

Poxvirus infections, 261

Rabbit fibroma virus infection, 263

Rabbit oral papillomavirus (ROPV) infection, 260

Rabbitpox (vaccinia) virus infection, 264

Endogenized viruses, 268

RNA viral infections, 264-269

Astrovirus infection, 264

Borna virus infection: borna disease, 264

Calicivirus infections, 264

Coronavirus infections, 266

European brown hare syndrome virus, 266

Hepatitis E virus infection, 267

Paramyxovirus infection, 267

Pleural effusion disease virus: coronaviral cardiomyopathy, 267

Rabbit enteric coronavirus infection, 267

Rabbit hemorrhagic disease virus infection, 264

Rabbit vesivirus infection, 266

Rabies virus infection, 267

Rotavirus infection, 267

Rabbit Endogenous Lentivirus type K (RELIK), 269 rabbit fibroma virus, 263-264

Rabbit Hemorrhagic Disease (RHD) virus, 264-266 rabbit kidney vacuolating virus, 261

Rabbit Oral Papilloma Virus (ROPV), 260-261

rabbit papillomatosis, 260

rabbit pox (rabbitpox virus, vaccinia), rabbit, 264

rabbit syphilis, 287

rabbit vesivirus, 266

rabies virus

guinea pig, 221

rabbit, 267

Radfordia affinis, mouse, 86, 87

Radfordia ensifera

mouse, 86, 87

rat, 153

radiculoneuropathy, rat, 154

Rat, 119

Age-related disorders, 154-159

Aging lesions of the liver, 156

Alveolar histiocytosis, 155

Cardiac valvular angiectasis, 156

Chronic Progressive Nephropathy, 157

Degenerative changes in the nervous system,

154

Degenerative osteoarthritis, 159

Endocardial spindle cell proliferation, 156 Hydronephrosis, 159

Myocardial degeneration/fibrosis, 155 Nephrocalcinosis, 158

Pancreatic islet cell hypertrophy and fibrosis, 157 Polyarteritis nodosa, 156 Radiculoneuropathy, 154

Renal papilary hyperplasia, 159

Urolithiasis, 158

Anatomic features, 119-121

Gastrointestinal system, 119

Hematology, 119 Lymphoreticular system, 119 Other anatomic features, 120 Respiratory system, 119 Skeletal system, 120 Urogenital system, 120 Bacterial infections, 132-145

Other bacterial infections, 140-145

Bacterial pyelonephritis/nephritis, 145

Corynebacterium kutscheri infection: Pseudotuberculosis; Corynebacteriosis, 140

Erysipelas rhusiopathiae infection, 141

Haemophilus spp. and V-factor-dependent pasteurellaceae infection, 141

Klebsiella pneumoniae infection, 142

Leptospira spp. infection, 142

Mycoplasma haemomuris infection, 142

Pasteurella pneumotropica infection, 142

Pseudomonas aeruginosa infection: pseudomoniasis, 143

Staphylococcus aureus infection: ulcerative dermatitis, 143

Streptobacillus moniliformis infection: rat bite fever, 144

Streptococcus pneumoniae infection: pneumococcal or diplococcal infection, 144

Primary enteric infections, 136-140

Campylobacter jejuni infection, 136

Clostridium difficile infection, 136

Clostridium piliforme infection: Tyzzer's disease,

137

Enterococcus spp. infection: enterococcal enteropathy, 138

Helicobacter spp. infection, 139

Lawsonia intracellularis infection, 139

Salmonella enterica infection, 140

Primary respiratory infections, 132-136

Bordetella bronchiseptica infection, 132

Cilia-associated respiratory (CAR) bacillus infection, 133

Mycoplasma pulmonis infection: murine respiratory mycoplasmosis, 134

Drug-related disorders, 162

Chloral hydrate ileus, 162

Ketamine-xylazine corneal lesions, 162

NSAIDS renal papillary and tubular necrosis, 162 Environmental disorders, 161-162

Conjunctivitis, keratitis, and other corneal lesions, 161

Dehydration, 161

High environmental temperature, 161

Light cycle aberration, 161

Phototoxic retinopathy and cataracts, 161

Quality of bedding, 162

Ringtail, 161

Fungal infections, 145-147

Aspirgillus spp. infection, 145

Blastomyces dermatitidis infection, 145

Dermatophyte infection: Dermatophytosis, Ringworm, 146

Encephalitozoon cuniculi infection, 146

Phycomycotic infection, 146

Pneumocystis carinii and Pneumocystis Wakefieldiae infections: pneumocystosis, 146 Introduction, 119

Miscellaneous disorders, 159-161

Auricular chondropathy, 159

Eosinophilic granulomatous pneumonia in brown Norway rats, 160

Hydrocephalus, 160

Malocclusion, 160

Persistent vaginal septum, 161

Neoplasms, 164-170

Histiocytic sarcoma, 167

Lymphoreticular tumors, 166

Cutaneous lymphoma: mycosis fungoides, 167 Large granular lymphocytic (LGL) leukemia, 166

Lymphoma and lymphocytic leukemia, 167

Mammary fibroadenoma, 164

Mammary adenocarcinoma, 166

Pituitary gland adenoma, 168

Testicular interstitial cell tumors, 169

Mesothelioma, 169

Zymbal's gland and preputial gland tumors, 164

Parasitic diseases, 151-154

Arthropod infestations, 153

Helminth infestations, 152-153

Other nematode infestations, 153

Rodentolepis and Hymenolepis infestations,

153

Rat (Continued )

Syphacia muris, syphacia obvelata and Aspicularis tetraptera: pinworms, 152

Taenia taeniaformis infestation, 153-154 Protozoal infections, 151-152

Cryptosporidium spp. infection: cryptosporidiosis, 152

Trichosomoides crassicauda infestation, 152

Trypanosomi lewisi: trypanosomiasis, 152

Viral infections121-130

DNA viral infections, 121-125

Cowpox virus infection, 124

Parvovirus infections, 122

Rat adenovirus Infection, 121

Rat cytomegalovirus infection, 122

Rat papillomavirus infection, 122

Rat polyomavirus infection, 122

RNA viral infections, 125-129

Hantavirus infection, 127

Parainfluenza virus 3 infection, 128

Paramyxovirus infections, 127

Pneumonia virus of mice infection, 128

Rat coronavirus infection: sialodacryoadenitis, 125

Rat Theilovirus infection, 128

Reovirus infection, 129

Rotavirus infection: infectious diarrhea of infant rats, 129

Sendai virus, 128

Viruses of emerging potential, 129-130

Astrovirus infection, 129

Hepatitis E virus, 129

rat bite fever, 67, 144, 229

Rat Cytomegalovirus (RCMV), 122

Rat Minute Virus (RMV), 122-124

Rat Papilloma Viruses (RnPV-1, RnPV-2), 122

Rat Parvovirus (RPV), 122-124

Rat Polyomavirus (Rat-PV-1), 122

Rat Respiratory Virus (RRV), now Pneumocystis spp., 146 rat sarcoma virus, 129

Rat Theilovirus (RTV), 128-129

Rat Virus (RV), 122-124

Rattus norvegicus, 119

rd1 (rodless retina) mutation, 3

rectal prolapse

guinea pig, 247

Brachyspira spp., 223

hamster, Lawsonia intracellularis, 184 mouse, 7

Citrobacter rodentium, 51, 52

Helicobacter spp., 56

pinworms, 85

rat, pinworms, 152

RELIK, see Rabbit Endogenous Lentivirus type K (RELIK) renal amyloidosis

guinea pig, 243

hamster, 194

mouse, 92 rabbit, 312 renal coccidiosis

guinea pig (Klossiella cobayae), 236 mouse (Klossiella muris), 83 renal infarction, mouse, 103

renal papillary hyperplasia, rat, 159

renal tubular hyaline bodies, mouse, 103

reovirus

gerbil, 200, 201

guinea pig, 221

hamster, 179

mouse, 36-37

rat, 129

reproductive epithelium, pseudocanalization/megakarya, mouse, 104

reproductive system, see also urinary system; ovarian tumors; testes

gerbil, 200

cystic ovaries, 208

neoplasia, 210

guinea pig, 216-217

male diseases, 249

mastitis, 231

neoplasia, 251

ovarian cysts, 249

pregnancy disorders, 243, 249

hamster, 174

mastitis, 186

pregnancy toxemia, 193-194

mouse, 8

adenomyosis, uterine, 104

disorders of, 103-105

endometrial hyperplasia, cystic, 104

endometritis, 62, 64

infertility, 89-90

Klebsiella spp., 64 mucometra/hydrometra, 103-104 Mycoplasma pulmonis, 63, 64 neoplasia, 115

Pasteurella pneumotropica, 65

teratoma, 115, 116

rabbit, 256-257

bicornuate uterus, 256, 257

disorders of, 310

Listeria monocytogenes (listeriosis), 280-281 mammary neoplasia, 322 mastitis, 285, 286, 313 mucometra, 310, 311

Pasteurella multocida, 284, 285

polyps, uterine, 256

pregnancy toxemia, 313

Treponema paraluis-cuniculi (syphilis), 287

uterine adenocarcinoma, 320, 321

vitamin E deficiency, infertility, 315

rat, 120

endometritis, 136

environmental influences, 161

infertility, 154, 161

neoplasia, 164-166, 169, 170

perstent vaginal septum, 161

respiratory epithelium, serous cells, rat, 119

respiratory system. see also Lung; Pneumonia

gerbil, 200

bacterial infections, 201

guinea pig, 215-216

Bordetta bronchiseptica, 222-223

neoplasia, 251

Streptococcus pneumoniae, 230

hamster, 174

bacteria, 186

Sendai virus, 178-179

mouse, 6

Cilia-Associated Respiratory (CAR) bacillus, 61

Chlamydia spp, 60-61

disorders of, 99-100

Mycoplasma pulmonis, 63-65 mycoses, 79

Pneumocystis murina, 79-80

Pasteurella pneumotropica, 65-66

Proteus mirabilis, 66

Sendai virus, 33-35

neoplasia, 112-113

rabbit, 255-256

Aspergillus spp. (aspergillosis), 292

Bordetella bronchiseptica, 271-272

Cilia-Associated Respiratory (CAR) bacillus, 272-273

Mycobacterium spp. (tuberculosis), 282

Pasteurella multocida, 283-285

Pneumocystis oryctolagi, 295-296

Staphylococcus aureus, 285-286

rat, 119

alveolar histiocytosis, 155

Aspergillus spp. (aspergillosis), 145

Bordetella bronchiseptica, 132-133 Cilia-Associated Respiratory (CAR) bacillus, 133-134 Corynbacterium kutscheri (pseudotuberculosis), 140­141

Haemophilus spp., 141 hantavirus pulmonary syndrome, 127 Mycoplasma pulmonis, 134-136

Pneumocystis spp., 146-147

Pneumonia Virus of Mice (PVM), 128

Cowpox Virus (CPXV), 124

Pasteurella pneumotropica, 142-143

Rat Respiratory Virus (RRV), 146

Sendai virus, 128

Sialodacryoadenitis Virus (SDAV), 125-127 Streptococcus pneumoniae, 144-145 reticulocytosis

gerbil, 199

rabbit, 255

retinal degeneration

mouse, rodless retina, 89, 99

rat, phototoxic retinopathy, 161 retroelements, mouse, 38-44 retrotransposon integration, 2 retroviruses

guinea pig, 221

hamster, 177, 179

mouse, 38-44, 109, 112

rabbit, 268-269

rat, 129

Reye's-like syndrome, mouse, 95 rhabdomyomatosis (cardiac glycogenosis), guinea pig, 241-242

rhabdomyosarcoma, mouse, 115, 116

RHD, see Rabbit Hemorrhagic Disease (RHD) rhinitis

guinea pig, Chlamydophila caviae, 224

hamster, Sendai virus, 179

mouse, 6

Mycoplasma pulmonis, 64

rabbit

Pasteurella multocida, 283, 284, 285

Staphylococcus aureus, 286

rat

Aspergillus spp., 145

Cowpox Virus (CPXV), 124

Klebsiella pneumoniae, 142

Mycoplasma pulmonis, 134-136

Pasteurella pneumotropica, 143

Sendai virus, 128

Sialodacryoadentitis Virus (SDAV), 125, 126, 127 Streptococcus pneumoniae, 145

ring-shaped nuclei, myeloid progenitor cells, mouse, 6 ringtail

mouse, 96, 97

rat, 161

ringworm, see dermatomycosis

Rodentolepsis spp., see helminth infestations rolling disease, Mycoplasma neurolyticum, mouse, 63 ROPV, see Rabbit Oral Papilloma Virus (ROPV) rotavirus

mouse (Epizootic Diarrhea of Infant Mice, EDIM),

37-38

rabbit, 267-268

rat (Infectious Diarrhea of Infant Rats, IDIR), 129

RTV, see Rat Teilovirus (RTV)

RV, see Rat Virus (RV)

S

sacculus rotundus, rabbit, 255

salivary glands

hamster, cytomegalovirus (CrHV-1), 175

Guinea Pig Cytomegalovirus (GPCMV), 219 mouse, 6, 10

Mouse Cytomegalovirus (MCMV), 15, 16, 17

Mouse Thymic Virus (MTV), 17 myoepitheliomas, 114, 115 perivascular lymphoid infiltrates, 99 Polyoma Virus (PyV), tumors, 19, 20 sexual dimorphism, 6

rat, sexual dimorphism, 119

Rat Polyomavirus (Rat-PyV), 122 Sialodacryoadentis Virus (SDAV), 125-127

Salmonella enterica (includes S. enteritidis, S. typhimurium), salmonellosis

gerbil, 203

guinea pig, 228

hamster, 184-185

mouse, 58-59

rabbit, 285

rat, 140

sand bathing, gerbil, 199

Sarcocystis spp., see protozoal infections sarcoma

mouse, 5, 20, 116

guinea pig, 252

sarcoma viruses

mouse, 39

rat, 129

sarcoptic mange, see acariasis, mange mites

scabies, rabbit, 295

scaly skin disease, mouse, 67-68

scent glands

gerbil, 200

guinea pig, 214

hamster, 174

rabbit, 254

Schmorl's disease (necrobacillosis), rabbit, 278-279, 308

SCID mouse, 11

thymic lymphoma, 109

scorbutic rosary, ribs, guinea pig, 240

scurvy, guinea pig, 239-241

SDAV, see Sialodacryoadenitis Virus (SDAV)

sebaceous adenitis, rabbit, 309

sebaceous gland

gerbil, 200

guinea pig, 214

segmented filamentous bacteria

mouse, 59-60

rabbit, 254

seizures

gerbil, 199, 206

guinea pig, 237

mouse, 97, 104

selenium deficiency

guinea pig, 241

seminal vesicle dilatation/atrophy, mouse, 104, 105

Sendai virus

gerbil, 200

guinea pig, 220

hamster, 178-179

mouse, 33-35, 63

rabbit, 267

rat, 128, 134, 142

sensory organs, disorders, mouse, 97

septicemia

gerbil, Listeria monocytogenes, 203

guinea pig

Aeromonas caviae, 228

Citrobacter freundii, 224

Corynebacterium pyogenes, 225

Escherichia coli, 226

Streptococcus pyogenes (hemorrhagic septicemia), 230

Klebsiella spp., 226

Leptospira spp., 226

Listeria monocytogenes, 226

Streptococcus equi subsp. Zooepidemicus, 229-230 hamster

Francisella tularensis, 185

Leptospira spp., 186

Pseudomonas aeruginosa, 186

Salmonella enterica, 185

mouse

Aerococcus viridans, 67

Proteus mirabilis, 66

Pseudomonas aeruginosa, 66

Streptobacillus moniliformis, 67

Streptococcus spp., 71

rabbit

Actinobacillus sp. 271

Listeria monocytogenes, 280

Pasteurella multocida, 283-285

Salmonella enterica, 285

Staphylococcus aureus, 286

Streptococcus spp., 286

Yersinia pestis, 288

Yersinia pseudotuberculosis, 288

rat

Pseudomonas aeruginosa, 143

Salmonella enterica, 140

serology, mouse, 13

serositis

guinea pig, Streptococcus pneumoniae, 230 mouse, Mouse Hepatitis Virus (MHV), 30 rabbit

Listeria monocytogenes, 280

Pasteurella multocida, 284

Salmonella enterica, 285

rat, Steptococcus pneumoniae, 145

serous cells, rat, respiratory epithelium, 119

sexual dimorphism, mouse, 6, 8, 9

Shiga toxin, rabbit, 277, 278

Shope Cottontail Rabbit Papillomavirus (CRPV), 260

Shope fibroma virus, rabbit, 263-264

Sialodacryoadenitis Virus (SDAV), rat, 125-127 skeletal system, see musculoskeletal system skin, see also barbering

gerbil

ectoparasites, 205

nasal dermatitis, 206

Staphylococcus aureus, 203-204 tail slip, 206

guinea pig

alopecia, 245

cheilitis, 246

dermatophytosis, 234 ectoparasites, 237-238 neoplasia, 250

pododermatitis, 228

Staphylococcus aureus, 228-229

hamster

ectoparasites, 191-192

epidermotropic lymphoma, 198

Hamster Polyoma Virus (HaPyV)-induced tumors, 177

mouse, 5

alopecia areata in C3H mice, 96 alopecia of B6 mice, 96 auricular chondritis, 96 clown mouse syndrome, 96 coryneforme hyperkeratosis, 67-69 dermatophytosis, 78 ear gangrene and notching, 96 ectoparasites, 86-88

Ectromelia Virus (ECTV), 22, 23 frostbite, 97

mechanical muzzle alopecia, 95

Polyoma Virus (PyV)-induced tumors, 20 ringtail, 96, 97

sloughing of extremities due to cotton nesting material, 97

Staphylococcus spp., 69-71

rabbit, 254-255

Cottontail Rabbit Papilloma Virus (CRPV),

260

dermatophytosis, 292-293 ectoparasites, 302-304 exfoliative dermatosis, 309 hutch burn 309

leporid herpesvirus 4 (LHV-4), 258-259 myxomatosis, 261-263 pododermatitis, 309

Shope fibroma virus, 263-264

sore hocks, 309

Staphylococcus aureus, 285-286

Treponemaparaluis-cuniculi (syphilis), 287 wet dewlap, 308

rat

dermatophytosis, 146 epitheliotropic lymphoma, 167 ectoparasites, 153-154

Cowpox Virus (CPXV), 124 ringtail, 161

Staphylococcus spp., 143-144

slobbers

guinea pig, 246

rabbit (wet dewlap), 308

small B cell lymphoma/leukemia, mouse, 109 small intestine, see enteritis; gastrointestinal system small T cell lymphoma, mouse, 110 snuffles, rabbit, 283-285

soft-tissue calcification, mouse, 93-94

sore hocks, rabbit, 309

sore nose (nasal dermatitis), gerbil, 204, 206 spinal cord

mouse, 10

Mouse Encephalomyelitis Virus (MEV), 36 osteosarcoma, 116 vertebral fracture, 105

rabbit

dysautonomia, 276 vertebral fracture, 309-310 rat

degenerative changes, 154 radiculoneuropathy, 154-155 spirochetosis

gerbil, Leptospira spp., 203

guinea pig

Brachyspira spp., 223

Leptospira spp., 226

mouse

Brachyspira spp., 50

Leptospira spp., 62-63

rabbit, Treponema paraluis-cuniculi, 287 Spironucleus muris, see protozoal infections splay leg, rabbit, 319 spleen

hamster

tularemia, 186

guinea pig, Kurloff cells, 214

mouse, 6, 9

Ectromelia Virus (ECTV), necrotizing, 22 hematopoiesis, 9, 10

Mouse Hepatitis Virus (MHV), necrotizing, 27 melanosis, 9, 10

Minute Virus of Mice (MVM) intranuclear inclusions, 18

Mouse Norovirus (MNV), 31

neoplasia, 43, 109, 110, 111 splenomegaly, 9, 20, 29, 59, 65, 66 rabbit, 255

hemosiderosis, 312

rat, 119, 120

hemosiderosis, 119

hematopoiesis, 119

Large Granular Lymphocytic (LGL) leukemia, 166, 167 white pulp, 119

Splendore-Hoeppli material

mouse, 70

rat, 144

splenic marginal zone lymphoma, mouse, 109 spongiosis, caudate nucleus, gerbil, 207 spontaneous hemorrhagic necrosis (SHN), CNS, fetal hamsters, 193

Sprague-Dawley rat

chronic progressive nephropathy, 157 histiocytic sarcoma, 167 mammary fibroadenoma, 164, 165 persistent vaginal septum, 161 pituitary gland adenoma, 168 polyarteritis nodosa, 156 staphylococcal dermatitis

gerbil, 203, 204 guinea pig, 228 mouse, 3, 70 rabbit, 309 rat, 143-144

Staphylococcus aureus, (staphylococcosis) gerbil, 203-204 guinea pig, 228-229 hamster, 186 mouse, 69-71, 86, 91, 96

bulbourethral gland cysts, 104 conjunctivitis, 98 rabbit, 285-286, 309 rat, 143-144

Staphylococcus epidermidis, mouse, 69-70

Staphylococcus xylosus

gerbil, 204 mouse, 68, 70-71

STAT1 deficiency, Mouse Norovirus (MNV) infection and, 31

steatorrhea, mouse, 37, 38 stereotypic behavior

mouse, 90

rabbit, 254

Stewart-Eddy (SE) polyoma virus, mouse, 19 stomach disorders, see gastric disorders strain-related pathology, 3-4

Streptobacillus moniliformis

guinea pig, 229

mouse, 67

rat, 144

streptococcal (enterococcal) enteropathy, rat, 138-139 streptococcosis

guinea pig, 229-230

hamster, 186

streptococcosis (Continued ) mouse, 71-72, 86, 96 rabbit, 286-287

Streptococcus agalactiae hamster, 186 mouse, 72

Streptococcus equisimilis, mouse 72

Streptococcus equi subsp. Zooepidemicus infections guinea pig, 229-230

Streptococcus pneumoniae (diplococcus/pneumococcus) guinea pig, 230 hamster, 186 rat, 144-145

Streptococcus viridans, mouse, 72 streptomycin toxicity, gerbil, 208 subcutaneous edema (atrial thrombosis), hamster, 195 submandibular salivary glands, sexual dimorphism, mouse, 6

subplacenta, guinea pig, 217

Superantigen (SAg), retroviral, 41

SV-5 (Simian Virus-5, PIV-2)

hamster, 179 gerbil, 200 guinea pig, 220

Swiss mouse, 2, 4 amyloidosis, 92 hemangiosarcoma hepatic neoplasia, 113 lymphoma, 42, 108, 109 pituitary adenoma, 102, 116 pulmonary adenoma, 92, 112 retinal degeneration, 99 syncytia

guinea pig corona-like virus, 220 mouse

Mouse Hepatitis Virus (MHV), 29, 30, 31 Mycoplasma pulmonis, 64, 65

Sendai virus, 34

rabbit

leporid herpesvirus 4 (LHV-4), 258, 259 myxoma virus, 263 paramyxovirus, 267

rat

Infectious Diarrhea of Infant Rats (IDIR), 129 syncytin-ory1, rabbit, 268

Syphacia spp., see Helminth infestations, pinworms syphilis, rabbit, 287

Syrian hamster, 173-174. see also hamster

T

tail

gerbil, slip 206

mouse, ringtail, 96-97

rat, ringtail, 161

tapeworm adults, see helminth infestations; tapeworms tapeworm cysts, see helminth infestations; tapeworms T cell-deficient mice, 11

T cell neoplasms gerbil, 198 mouse, 41, 43, 109, 110 rabbit, 322

rat, 167

teeth

gerbil, 200

malocclusion, 207 periodontal disease/caries, 206-207

guinea pig, 216

malocclusion, 246

hamster

Hamster Parvovirus (HPV) aplasia, 175, 176 malocclusion, 196

mouse, 6

malocclusion, 100

rabbit, 256

malocclusion, 318-319

vitamin D deficiency, 315

rat, malocclusion, 160

Telazol nephrotoxicity, rabbit, 316 teratoma/teratocarcinoma

guinea pig, 251

mouse, 3, 115, 116

testes

guinea pig

Brucella spp., 223

degeneration (vitamin E deficiency), 241

hamster, hypoplasia, 175, 176 mouse

chimera, 5

teratoma, 115, 116

rabbit

abscess, 273

seasonal involution, 257

rat

hemorrhage, Rat Virus (RV), 123 interstitial cell tumor, 169, 170

tetanus, hypocalcemic, lactating does, rabbit, 313

Theiler's virus, see Mouse Encephalomyelitis Virus (MEV) Theilovirus, Rat (RTV), rat, 128

third eyelid, prolapse, deep gland of, 309

thymic agent. Mouse Thymic Virus (MTV), 17

thymic lymphoma, mouse, 41, 42, 109, 110

thymic necrosis virus. Mouse Thymic Virus (MTV), 17 thymoma, rabbit, 309, 322

thymus

gerbil, 200

guinea pig, 214, 215

mouse, 9, 11

lymphocytic apoptosis, 92 lymphoma, 41, 42, 109, 110

Murine Leukemia Virus (MuLV), 41, 42

Mouse Thymic Virus (MTV), 17

rabbit, 255

rat, 119

TMCH, Transmissible Murine Colonic Hyperplasia (Citrobacter rodentium), 50-52

Toolan H-1 virus (H-1 virus), 122

tooth abscess, rabbit, 309

tooth aplasia, Hamster Parvovirus (HaPV), 176 toroviruses, rabbit, 266

toxic disorders

gerbil, 208

antibiotic, 201

lead, 209

streptomycin, 208

guinea pig, 244

antibiotic, 224-225

hamster, antibiotic, 180-181 mouse

chloroform, 103

NSAIDS-associated nephropathy, 103

rabbit, 313

aflatoxicosis, 316

antibiotic dysbiosis, 273

copper, 315

drug, 316

fluoride, 315

fluoroquinalone arthropathy, 316

ionophore myopathy, 316

ketamine/xylazine cardiomyopathy, 316

lead, 315-316

poisonous plant, 316

Telazol nephrotoxicity 316

vitamin A, 314

vitamin D, 315

rat

drug-related, 162

chloral hydrate ileus, 162

ketamine/xylazine corneal lesions, 162

NSAIDS renal papillary and tubular necrosis, 162

phototoxic retinopathy and cataracts, 161 Toxoplasma gondii (toxoplasmosis), see protozoal infections tracheal injury, intubation, rabbit, 310 transmissible ileal hyperplasia, hamster, 183-184 transmissible lymphoma, hamster, 176 Transmissible Murine Colonic Hyperplasia (TMCH), mouse, 50-52

Treponema paraluis-cuniculi, rabbit syphilis, 287 trichobezoar, rabbit, 307, 308 trichoepithelioma/trichofolliculoma

guinea pig, 250

Hamster Polyoma Virus (HaPyV) associated, 176, 177 Trichomonas, Tritrichomonas spp., see protozoal infections Trichophyton mentagrophytes, see dermatophytosis Trichosomoides crassicauda, bladder threadworm, rat, 152-153

trichotillomania, mouse, 90-91, 100 Trixacarus caviae, guinea pig mange, 237-238 Trypanosomiasis, see protozoal infections tuberculosis

guinea pig, 227

hamster, 186

rabbit, 282

tularemia (Francisella tularensis)

hamster, 185-186

rabbit, 278

tumors, see neoplasia

Turkmenia rodent poxvirus, rat, 124

typhlitis, see enteritis/enterocolitis/enterotyphlocolitis Tyzzer's disease

gerbil, 201-203

guinea pig, 225

hamster, 181-182

mouse, 53-54

rabbit, 275-276

rat, 137-138

U

ulcerative dermatitis

mouse, 70-71, 86, 96

rat, 143-144

ulcerative pododermatitis

guinea pig, 228, 244

rabbit, 309

urethral obstruction

guinea pig, 216

mouse, 8, 104

rabbit, 311

urinary bladder, see bladder, urinary

urinary bladder, threadworm (Trichosomoides crassicauda), rat, 152, 153

urinary sludge

guinea pig, 216

rabbit, 310, 311

urinary system

gerbil, 200

amyloidosis, 208

Bowman's capsule lamina muscularis, 200 glomerulonephropathy, 208 lead toxicity, 209

guinea pig

amyloidosis, 243-244 coccidiosis (Klossiella cobayae), 236 Corynebacterium renale, 226

cystitis, 248

nephrosclerosis, 247-248

urolithiasis, 248-249

hamster, 174

amyloidosis, 194

glomerulonephropathy, 196

mouse, 8, 9

amyloidosis, 92

Bowman's capsule cuboidal epithelium, male, 8, 9 chloroform toxicity, 103 chronic nephropathy, 102 coccidiosis (Klossiella muris), 83 disorders of, 102-103 glomerulonephritis, 102 hydronephrosis, 102-103 inclusion body nephritis, 103

Klebsiella spp., 62

Klossiella muris, 83

Murine Urologic Syndrome (MUS), 104, 105

NSAIDs-associated nephropathy, 103

Pasteurella pneumotropica, 65 polycystic disease, 103 Polyoma Virus (PyV), 20 renal infarction, 103 renal tubular hyaline bodies, 103

Reye's-like syndrome, 95

rabbit, 256

aging-related disease, 311

amyloidosis, 312 Encephalitozoon cuniculi, 293-294 kidney disorders, misc., 311 polycystic disease, 319 rabbit kidney vacuolating virus, 261 renal tubular intranuclear inclusions, 261 Staphylococcus aureus, 286

urinary system (Continued )

urinary sludge and urolithiasis, 310, 311 rat

chronic progressive nephropathy, 157-158 hydronephrosis, 159 nephrocalcinosis, 158

papillary hyperplasia, 159

pylonephritis, 145

Trichosomoides crassicauda (bladder threadworm), 152-153 urolithiasis, 158-159

urine, hyperpigment, rabbit, 256

urine scalding, rabbit, 309

urobilinogen, rabbit, 256

urogenital disorders, see reproductive system and urinary system

urogenital system

gerbil, 200

guinea pig, 216-217

hamster, 174

mouse, 8, 9

rabbit, 256-257

rat, 120

urolithiasis

guinea pig, 248-249

rabbit, 310, 311

rat, 158-159

uterine adenocarcinoma, rabbit, 256, 320, 321

uterine leiomyoma, guinea pig, 251

uterus, see reproductive system

uveitis, phacoclastic (Encephalitozoon), rabbit, 295

V

vaginal closure membrane, guinea pig, 216-217

vaginal epithelial mucification, guinea pig, 217

vaginal septum, persistent

mouse, 103

rat, 161

venereal spirochetosis (Treponema paraluis-cuniculi), rabbit, 287

vertebral disc degeneration

mouse, 105

rabbit, 309

vertebral fracture

mouse, 105

rabbit, 309-310

vesivirus, rabbit, 266

vestibular syndrome

mouse, 98

rabbit, 284

V-factor-dependent Pasteurellaceae infection, rat, 141-142

viral hemorrhagic disease, Rabbit Hemorrhagic Disease (RHD), 264-266

vitamin A deficiency, rabbit, 314

vitamin A excess, rabbit, 314

vitamin C deficiency, guinea pig, 239-241

vitamin D deficiency, rabbit, 315

vitamin D excess, rabbit, 315

vitamin E deficiency

guinea pig, 241

hamster, 193

rabbit, 315

vomeronasal organ

mouse, 6

amyloid-like material, 93

W

walking dandruff, rabbit, 302

Wallerian degeneration, spinal cord, rat, 154

wasting disease (immunodeficient rodents)

mouse

Mouse Hepatitis Virus (MHV), 27

Pneumocystis murina, 79

Pneumonia Virus of Mice (PVM), 32

Sendai virus, 33

rat

Pneumocystis spp., 146

Rat Polyoma Virus (Ra-PyV), 122

Sialodacryoadenitis Virus (SDAV), 127

Watanabe Heritable Hyperlipidemic (WHHL) rabbit, 253, 314

water bottle accidents, mouse, 11, 92

wet dewlap, rabbit, 308

wet tail, hamster, 183

WHHL, see Watanabe Heritable Hyperlipidemic (WHHL)

Whitten effect, mouse, 90

Wistar, Wistar Furth rat

Large Granular Lymphocytic (LGL) leukemia, 166-167 persistent vaginal septum, 161

pituitary gland adenoma, 168-169

X

xanthomatosis, rabbit, 314, 315

X virus (GPXV), guinea pig, 219

X zone, adrenal mouse, 9

Y

Yersinia pestis (plague), 288

Yersinia pseudotuberculosis (yersiniosis, pseudotuberculosis) guinea pig, 230-231

hamster, 186

rabbit, 288

Z

zoonosis

guinea pig

Campylobacter jejuni, 224

dermatophytosis, 234

Listeria monocytogenes, 226

Mycobacterium spp., 227

Salmonella enterica, 228

Streptococcus pneumoniae, 230

Yersinia pseudotuberculosis, 230, 231

hamster

Campylobacter jejuni, 180

Francisella tularensis, 186

Helicobacter cinaedi, 182

Lymphocytic Choriomeningitis Virus (LCMV),

178

Rodentolepis nana, 190

Salmonella enterica, 184

mouse

Coxiella burnetii, 61

Cryptosporidium spp., 82

Leptospira spp., 62

Lymphocytic Choriomeningitis Virus (LCMV), 23

Rodentolepis nana, 85

Salmonella enterica, 58

Streptobacillus moniliformis, 67

rabbit

Campylobacter jejuni, 272

Cheylitiella parasitovorax, 302, 303

Cryptosporidium spp., 297

Escherichia coli (enterohemorrhagic), 278 dermatophytosis, 292, 293

Giardia duodenalis, 300

Hepatitis E virus, 267

Listeria monocytogenes, 280

Sarcoptes scabei, 303

Toxoplasma gondii, 300

Yersinia pseudotuberculosis, 288

rat

Campylobacter jejuni, 136

Cryptosporidium spp., 152

Cow Pox Virus (CPXV), 124, 125 dermatophytosis, 146 hantavirus, 127

Hepatitis E virus, 129

Infectious Diarrhea of Infant Rats virus (IDIR), 129

Leptospira spp., 142

Rodentolepis nana, 153

Salmonella enterica, 140

Streptobacillus moniliformis, 144

Streptococcus pneumoniae, 144

Zymbal's gland tumor, rat, 164, 165