CONTENTS
Introduction................................................................................................................................... 127
Interaction of Nef with the Host T Cell........................................................................................
128Nef Structure and Interaction with Cellular Proteins........................................................... 128
Interaction of Nef with the Endocytosis Machinery............................................................. 129
Interaction of Nef with Signaling Proteins of the T Cell
Receptor (TCR) Environment................................................................................................ 130
TCR Signals that Stimulate Anti- and Proapoptotic Pathways.................................................... 131
Nef Signals that Stimulate Anti- and Proapoptotic Pathways...................................................... 133
Survival Strategies of Viruses: Antiapoptosis and Immune Evasion................................... 133
Interference of Nef with the Death Receptor/Extrinsic Pathway.......................................... 134
Interference of Nef with the Mitochondria-AssociatedHntrinsic Pathway........................... 135
Nef and Immune Evasion of HIV.................................................................................................. 136
Proapoptotic Effects of Nef.......................................................................................................... 137
Conclusion..................................................................................................................................... 138
References..................................................................................................................................... 138
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