Rat Polyomavirus Infection
Rat polyomavirus (Rat-PyV), serologically distinct from polyoma and K viruses of mice, can infect rats, but its prevalence is unknown. Rat-PyV initially became apparent in a colony of Rowett (athymic) nude (rnu) rats, in which 10-15% developed a wasting disease, dyspnea with pneumonia and parotid sialadenitis.
Intranuclear inclusions were present in duct epithelium and, to a lesser extent, acini of parotid glands, and lungs. Euthy- mic rats did not develop the disease. Viral antigen was found in salivary glands, larynx, and, less often, bron- chiolar epithelium and kidney. Since the virus has not been isolated, serological screens of laboratory rat populations for this agent are not performed. Conspicuous intranuclear inclusions can be seen in salivary gland epithelium (Fig. 2.6), bronchiolar epithelium, and alveolar lining cells, resulting in interstitial pneumonia and weight loss. Other organs appear to be histologically normal. This infection has periodically arisen on multiple occasions among rnu rats.
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