Adenovirus Infection

Adenoviral intranuclear inclusion bodies have been observed in ileal enterocytes in tissues collected from hamsters during the first few weeks of life. Typical adenoviral inclusions have been observed only in ham­sters less than 4 weeks of age.

In addition, antibodies to the MAdV-2 (K87) strain of mouse adenovirus are com­monly present in hamsters from commercial suppliers, and antibodies to MAdV-1 have been occasionally detected. Large, amphophilic, intranuclear inclusions may be present in the enterocytes lining villi of the jejunum and ileum and rarely in the cryptal epithelial cells. Infection is subclinical, and there is no evidence of intestinal tract damage or inflammatory response. It is unclear if hamsters have their own indigenous adeno­virus, or if it has been acquired from other species.

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