Neoplasia of the Reproductive System

Neoplasms of the female reproductive tract that arise in aged mice include papillary cystadenomas of the ovary, ovarian tubular adenomas, granulosa cell, and thecal cell tumors. Dysgerminomas are exceedingly rare.

In p53⁺/^- mice, malignant granulosa cell tumors with metastases have been noted occasionally. Vascular tumors (heman­giomas and hemangiosarcomas) occur in both the ovary and uterus. Uterine endometrial stromal tumors, adeno­carcinomas, and leiomyosarcomas of uterine wall are other neoplasms encountered in this species. The uterus may also be a primary site for development of histocytic sarcomas. Ovarian teratomas are rare, except in LT/Sv mice. Neoplasms of the male reproductive tract are relatively rare, except in GEMs. Occasionally, sebaceo- squamous adenomas and carcinomas may arise from preputial glands of both males and females, and tumors may also arise in other accessory sex glands.

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